Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba

Li, Yucui; Liang, Hai-Chun; Chen, Haiming; Tan, Lirong; Yi, Yuyang; Qin, Zhen; Zhang, Weiyang; Wu, Dian‐Wei; Li, Chuwen; Lin, Rong-Feng; Su, Zi-Ren; Lai, Xiaoping

doi:10.1016/j.phymed.2012.08.008

Cited by 55 publications

(44 citation statements)

References 26 publications

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“…Pogostone (Figure 3) is one of the major constituent of Pogostemon cablin, and possesses various bioactivities, such as anti-fungal (Li et al, 2012), anti-bacterial (Peng et al, 2014), pesticidal (Huang et al, 2013), and anti-inflammatory activities (Su et al, 2015). Recent studies have revealed that pogostone exhibited potent anti-proliferative activities against multiple human cancer cell lines, especially on human colorectal cancer cells HCT116 (IC50: 18.7 ± 1.93 μg/mL; Cao et al, 2016).…”

Section: Components Isolated From Tcms Targeting the Phosphoinositidementioning

confidence: 99%

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine

et al. 2017

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Traditional Chinese medicines (TCMs) have been used in China for more than two thousand years, and some of them have been confirmed to be effective in cancer treatment. Protein kinases play critical roles in control of cell growth, proliferation, migration, survival, and angiogenesis and mediate their biological effects through their catalytic activity. In recent years, numerous protein kinase inhibitors have been developed and are being used clinically. Anticancer TCMs represent a large class of bioactive substances, and some of them display anticancer activity via inhibiting protein kinases to affect the phosphoinositide 3-kinase, serine/threonine-specific protein kinases, pechanistic target of rapamycin (PI3K/AKT/mTOR), P38, mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases (ERK) pathways. In the present article, we comprehensively reviewed several components isolated from anticancer TCMs that exhibited significantly inhibitory activity toward a range of protein kinases. These components, which belong to diverse structural classes, are reviewed herein, based upon the kinases that they inhibit. The prospects and problems in development of the anticancer TCMs are also discussed.

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Section: Components Isolated From Tcms Targeting the Phosphoinositidementioning

confidence: 99%

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine

et al. 2017

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“…PO was isolated from Pogostemon cablin as previously described (Li et al, 2012). Briefly, the dried aerial parts of Pogostemon cablin (3 kg) were exhaustively extracted through water-steam distillation.…”

Section: Extraction and Isolation Of Pomentioning

confidence: 99%

“…Previously, we isolated PO from Pogostemon cablin and studied its pharmacokinetic properties through intravenous and oral administration in mice and rat, respectively, as well as its metabolic characteristics in rat. The results demonstrated that PO was easily absorbed after oral administration and had a high bioavailability (Li et al, 2012;Chen et al, 2013). In this study, potential anti-inflammatory effect of PO in vitro and in vivo was investigated by measuring the protein and mRNA expression of proinflammatory mediators including TNF-α, IL-6, IL-1β, IL-12, COX-2 and NO.…”

Section: Introductionmentioning

confidence: 99%

“…1), a naturally occurring chemical compound isolated from Pogostemon cablin, is a chemical marker required by law for the quality control of essential oil of Pogostemon cablin in China (China Pharmacopoeia Committee, 2010). PO has been reported to possess potent anti-bacterial (Kong, 1986;Osawa et al, 1990;Li et al, 2012), anti-fungal (Mo et al, 2004), and pesticidal (Michihiko and Minoo-shi, 2003;Huang et al, 2013) activities. Previously, we isolated PO from Pogostemon cablin and studied its pharmacokinetic properties through intravenous and oral administration in mice and rat, respectively, as well as its metabolic characteristics in rat.…”

Section: Introductionmentioning

confidence: 99%

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Pogostone suppresses proinflammatory mediator production and protects against endotoxic shock in mice

Xian

et al. 2014

Journal of Ethnopharmacology

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“…It is commonly used for the treatment of common cold, diarrhea, fever, etc. As one of the secondary metabolites from Herba Pogostemonis [1], pogostone (PO) exhibits extensive biological activities, such as potential anti-bacterial, anti-candida, anti-fungal, insecticidal, anti-inflammatory, and immunosuppressive activities [2][3][4]. Recently, Huang et al [5] have reported that PO had strong insecticidal activity against Spodoptera litura and Spodoptera exigua, especially in the aspect of antifeedant, larvicidal, growth inhibitory, etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of pogostone by one-step

Chen

Zhou

Liu

et al. 2016

Journal of Asian Natural Products Research

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Pogostone, isolated from Pogostemon cablin, has many biological activities such as potential antibacterial, anticandida, and antifungal. Traditional extraction leads to low output of PO about 17.6 mg/kg from Herba Pogostemonis. The previous literature had reported a synthetic study and the yield had reached 4.48% with strictly controlled reaction conditions. The two methods above cannot meet the large demand of PO; we report a new synthesis method. 4-hydroxy-6-methyl-2-pyrone (1) was added in toluene, with the existence of acylation catalyst 4-dimethylaminopyridine (DMAP), 4-methylvaleric acid (2), and condensing agent dicyclohexylcarbodiimide (DCC), PO was synthesized after the combination of 3-carbon of (1) with 1-OH of (2) in the acylation reaction. The purity had reached 98%, determined by HPLC. The structure was confirmed by spectroscopic methods including infrared, electron ionization mass spectrometry, and nuclear magnetic resonance spectroscopy. PO was totally synthesized in one step including cyclization, with total yield of 27.2%.

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Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba

Cited by 55 publications

References 26 publications

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine

Pogostone suppresses proinflammatory mediator production and protects against endotoxic shock in mice

Synthesis of pogostone by one-step

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