Anti-carcinogenic Activity of Taraxacum Plant. II.

Takasaki, Midori; Konoshima, Takao; Tokuda, Harukuni; Masuda, Kazuo; Arai, Yôko; Shiojima, Kenji; Ageta, Hiroyuki

doi:10.1248/bpb.22.606

Cited by 103 publications

(70 citation statements)

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“…Additionally, the effect on cell proliferation could be ascribed to the inhibition of ERK activity, with ERK being a major determinant in the MAPK-pathway involved in cell survival, differentiation and cell growth (22). Inhibition of tumor cell proliferation by Taraxacum extracts has been reported earlier and was found to be due to triterpenoids and sesquiterpenes (5,6). Since these compounds are also present in the roots, and no effect of DRE was observed on the growth of either cell line, our results suggest that the inhibitory effect may result from phenolic compounds as dandelion leaves are characterized by higher polyphenolic acids and flavonoid contents (23).…”

Section: Discussionmentioning

confidence: 87%

“…Anticarcinogenic activities have been reported for the aqueous root extract of Taraxacum japonicum on mouse skin tumors (5). Further study revealed that taraxasterol and taraxerol, triterpenoids isolated from T. japonicum, were responsible for the observed effect on mouse skin tumors and that taraxasterol inhibited spontaneous mammary carcinogenesis, after oral administration (6). Taraxinic acid, isolated from Taraxacum coreanum showed potent antiproliferative activity against HL-60 cells (7) and the ethanolic extracts of the Chinese dandelion root (Taraxacum mongolicum) inhibited the growth of B16 2F2 mouse melanoma cells (8).…”

Section: Introductionmentioning

confidence: 96%

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Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells

Sigstedt

Hooten²,

Callewaert³

et al. 2008

Int J Oncol

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Abstract. Ethnotraditional use of plant-derived natural products plays a significant role in the discovery and development of potential medicinal agents. Plants of the genus Taraxacum, commonly known as dandelions, have a history of use in Chinese, Arabian and Native American traditional medicine, to treat a variety of diseases including cancer. To date, however, very few studies have been reported on the anti-carcinogenic activity of Taraxacum officinale (TO). In the present study, three aqueous extracts were prepared from the mature leaves, flowers and roots, and investigated on tumor progression related processes such as proliferation and invasion. Our results show that the crude extract of dandelion leaf (DLE) decreased the growth of MCF-7/AZ breast cancer cells in an ERK-dependent manner, whereas the aqueous extracts of dandelion flower (DFE) and root (DRE) had no effect on the growth of either cell line. Furthermore, DRE was found to block invasion of MCF-7/ AZ breast cancer cells while DLE blocked the invasion of LNCaP prostate cancer cells, into collagen type I. Inhibition of invasion was further evidenced by decreased phosphorylation levels of FAK and src as well as reduced activities of matrix metalloproteinases, MMP-2 and MMP-9. This study provides new scientific data on TO and suggests that TO extracts or individual components present in the extracts may be of value as novel anti-cancer agents. IntroductionPlants of the genus Taraxacum, also known as dandelions, are members of the Asteraceae family. These perennial plants are widespread throughout the warmer temperate zones of the Northern Hemisphere and have been used for centuries as a remedy for various ailments by several societies. Dandelions play a pivotal role in traditional Chinese medicine (TCM) and are frequently used for treatment of breast, uterine and lung tumors as well as hepatitis and digestive diseases (1,2), while Native Americans use dandelion roots and herbs to treat kidney disease, dyspepsia and heartburn. In traditional Arabian medicine, dandelions have been applied to remedy liver and spleen disorders (3), whereas European herbalists authorize the use of dandelions for fever, boils, eye problems, diabetes and diarrhea (4).The variety of health benefits associated with the use of dandelions has been attributed to specific Taraxacum species as extracts of the whole plants or specific plant parts. Anticarcinogenic activities have been reported for the aqueous root extract of Taraxacum japonicum on mouse skin tumors (5). Further study revealed that taraxasterol and taraxerol, triterpenoids isolated from T. japonicum, were responsible for the observed effect on mouse skin tumors and that taraxasterol inhibited spontaneous mammary carcinogenesis, after oral administration (6). Taraxinic acid, isolated from Taraxacum coreanum showed potent antiproliferative activity against HL-60 cells (7) and the ethanolic extracts of the Chinese dandelion root (Taraxacum mongolicum) inhibited the growth of B16 2F2 mouse melanoma cells (8). Antitumor...

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 96%

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells

Sigstedt

Hooten²,

Callewaert³

et al. 2008

Int J Oncol

View full text Add to dashboard Cite

show abstract

“…6-B). 다른 연구에서도 민들레의 열수 추출물을 이용하여 항종 양 효과 (Baba et al, 1981;Kotobuki et al, 1965)가 구명하 였으며, Takasaki et al(1999aTakasaki et al( , 1999b …”

Section: 총 플라보노이드 함량unclassified

“…(2003)는 민들레 추출물이 항산화 활성이 있어 프리라디칼을 소거하며, Mascolo(1987)은 동물에서 항염활성이, Kotobuki et al(1965)은 항종양 활성이, Takasaki et al(1999aTakasaki et al( , 1999b (Krygier et al, 1982). (Banwart et al, 1985).…”

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Antioxidant Activity and Cytotoxicity of Different Taraxacum Species in Korea

천상욱¹

2012

Korean Journal of Crop Science

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Contents of phenolics and flavonoids, antioxidant activity and cytotoxicity were investigated in the methanol extracts of three different Taraxacum species, Taraxacum coreanum, Taraxacum mongolicum, and Taraxacum officinale. Total phenolics content at 1000 mg kg -1 was more present in shoot parts than in roots, and was highest in T. mongolicum shoot and root extracts (76.8 and 40.0 mg kg -1 , respectively), followed by T. coreanum and T. officinale (p < 0.05). Total flavonoid level had same tendency to total phenolics among Taraxacum species, showing lower amounts (6.5～36.4 mg kg -1 ) than total phenolics. The antioxidant activity of the methanol extracts from all the species dose-dependently increased. DPPH free radical scavenging activity at 1,000 mg kg -1 was highest in shoot and root extracts from T. mongolicum by 89.6 and 83.4%, respectively. According to MTT assay, cell viability of Calu-6 (human pulmonary carcinoma) was lowest in the T. mongolicum shoot and root extracts (IC 50 values=83.4 and 66.4 mg kg -1 , respectively), and followed by T. coreanum and T. officinale (lowest). Calu-6 was more sensitive to the extracts than SNU-601 (human gastric carcinoma). Antioxidative and anticancer activities in three different Taraxacum species was more correlated with total phenolics content (r 2 =0.0097 to 0.6213) than with total flavonoids level (r 2 =0.0027 to 0.4627). The results showed total phenolics content and total flavonoids level were highly correlated with anticancer activity and antioxidant activity, and their content and activities were different depending on species.

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“…5. In addition to cupaniol, ficaprenol 12, 14,15) a-and b-tocopherols, 16) b-amyrin, 17) and taraxerol 17) were isolated from the AcOEt-soluble fraction and characterized by comparing the NMR and MS data with the reported values, while (Ϫ)-epicatechin 18,19) and proanthocyanidin A2 20) were isolated from the AcOEt-insoluble fraction of the MeOH extract.…”

Section: Ei-ms (70 Ev) Spectrum and Fragmentation Pattern Of Compoumentioning

confidence: 99%