Anti-caries evaluation of a nano-hydroxyapatite dental lotion for use after toothbrushing: An in situ study

Improving Oral Health with Fluoride-Free Calcium-Phosphate-Based Biomimetic Toothpastes: An Update of the Clinical Evidence

“…Some studies were cited more than once in the tables because they examined more than one aspect of improving oral health in the same study. The HAP toothpaste works as well as the fluoride toothpaste in remineralizing enamel yes Amaechi [42] Apagard Deep Care (5% nHAP) along with Apagard M-plus (5% nHAP) Placebo along with Apagard M-Plus (5% n-HAP) No studies were found.…”

Nanohydroxyapatite in dentistry: A comprehensive review

“…Clinically toothpaste containing either 10% or 15% nHA (10 or 15%) solely or supplemented with potassium nitrate was as effective as calcium sodium phosphosilicate for relief of dentine hypersensitivity symptoms when applied at least twice daily. The study also found that toothpaste containing 15% nHA was more effective than toothpaste containing 10% nHA at reducing dentin sensitivity ( Amaechi et al, 2021 ). 20% nHA cream is equally effective to 20% pure silica containing dental cream in relieving the dentine hypersensitivity symptoms ( Amaechi et al, 2018 ).Dentifrices containing nHA have showed complete closure of dentine tubules and intertubular dentine coverage with significant mineral deposition on the dentin surface ( Bologa, et al, 2020 ).…”

Nanotechnology in toothpaste: Fundamentals, trends, and safety

“… Nano-HAP 10 wt% -Nano-HAP 10 wt%/950 ppm F −950 ppm F [ 68 ] Remineralization Nano-HAP 10 wt%-950 ppm F toothpaste significantly reduces lesion progress in comparison to other formulations and decreases the demagnetization rate of teeth. Nano-HAP [ 69 ] Remineralization Toothpaste containing 5 % Nano-HAP effectively remineralized initial caries and inhibited demineralization of healthy enamel Nano-HAP [ 70 ] Remineralization Nano-HAP showed enhanced remineralization capability in comparison to F varnish Amorphous Calcium Phosphate, Nano-HAP and Calcium Sucrose Phosphate [ 71 ] Remineralization calcium sucrose phosphate shows a maximum increase in the enamel surface microhardness followed by Nano-HAP and Casein phospho peptide-amorphous calcium phosphate but Calcium Sucrose Phosphate in toothpaste strengthened the enamel more than Nano-HAP and CPP-ACP Nano-HAP/NovaMin [ 72 ] Remineralization Both Nano-HAP and NovaMin (a synthetic mineral compound composed of calcium, sodium, phosphorus, and silica) were effective for remineralization of caries-like lesions of primary teeth and no significant difference was detected in their efficacy. Nano-HAP [ 73 ] Remineralization Nano-HAP dentifrice caused remineralization comparable to a F dentifrice, and inhibited caries development Nano-HAP/Tricalcium phosphate [ 74 ] Remineralization The study showed that Nano-HAP had the potential to remineralize artificial carious lesion better than TCP and F Nano-HAP [ 75 ] Remineralization Nano-HAP and F had the potential to remineralize initial enamel lesions Nano-HAP/F [ 76 ] Remineralization Nano-HAP paste were unable to reduce dental demineralization in vitro.…”