Anti-CCP antibodies are not a marker of severity in established rheumatoid arthritis: a magnetic resonance imaging study

Abstract

Our results have not established an association of anti-CCP with the severity of disease. To date, we cannot corroborate anti-CCP as a prognostic tool in patients with established RA.

Matrix metalloproteinase-3 levels in relation to disease activity and radiological progression in rheumatoid arthritis

“…It is already known that some features when present, are associated with a worse outcome of the disease, such as the presence of high titer rheumatoid factor, smoking and HLA-DRB1". 18,19 Porto et al continued: "Regarding the prognostic role of anti-CCP, its association with disease activity and functional capacity has still not been clarified, although many studies suggest that these antibodies are associated with more severe and erosive disease, 20,23 especially in cases of initial RA. 24,27 It is worth noting the methodological heterogeneity of the studies that analyzed the association of anti-CCP with structural damage.…”

Diagnostic value of autoantibodies combined detection for rheumatoid arthritis

“…6,7,19 While the high specificity of anti-CCP is undisputed, RF is often considered a reasonably sensitive (81.61%) but relatively non-specific (44%) marker of RA. Correspondingly, a specific and sensitive serological test is needed.…”

“…Anti-CCP, which is extremely specific (86.73%) and has a reasonable sensitivity of 75.14% in this study, appears to be a good prognostic marker and has a high discriminating power between erosive and nonerosive RA. 6,7,19 While the high specificity of anti-CCP is undisputed, RF is often considered a reasonably sensitive (81.61%) but relatively non-specific (44%) marker of RA.…”

“…[5][6][7][8] So, a specific and sensitive serological test is needed for early diagnosis and early intensive therapy which allows achieving good disease control. [5][6][7][8] So, a specific and sensitive serological test is needed for early diagnosis and early intensive therapy which allows achieving good disease control.…”

“…(anti-CCP) antibodies can be discovered earlier than the clinical manifestation of RA. [5][6][7][8] So, a specific and sensitive serological test is needed for early diagnosis and early intensive therapy which allows achieving good disease control.…”