Anti-CD3/Anti-CD28 Monoclonal Antibody–Coated Suture Enhances the Immune Response of Patients With Head and Neck Squamous Cell Carcinoma

Shibuya, Terry Y.; Wei, Wei Zen; Zormeier, Michelle; Ensley, John F.; Sakr, Wael; Mathog, Robert H.; Meleca, Robert J.; Yoo, George H.; June, Carl H.; Levine, Bruce L.; Lum, Lawrence G.

doi:10.1001/archotol.125.11.1229

Cited by 21 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[17][18][19][20] We have reported previously on the immuneenhancing properties of ␣CD3/␣CD28-coated surgical suture. 27 Stimulation with ␣CD3/␣CD28 beads enhanced proliferation in both groups (Figures 3 and 4). Bead stimulation enhanced the production of IL-2, IFN-␥, and TNF-␣ in both groups (Table 2).…”

Section: Commentmentioning

confidence: 91%

Anti-CD3/Anti-CD28 Bead Stimulation Overcomes CD3 Unresponsiveness in Patients With Head and Neck Squamous Cell Carcinoma

Shibuya

Wei

Zormeier

et al. 2000

Arch Otolaryngol Head Neck Surg

Self Cite

View full text Add to dashboard Cite

A subpopulation of patients with HNSCC who are nonresponders to alphaCD3 stimulation has been identified, showing reduced proliferation and IL-12 and IFN-gamma secretion. Nonresponders stimulated with alphaCD3/alphaCD28 beads reversed immune unresponsiveness and induced a type 1 cytokine response. Bead-generated ATCs from patient 11 in the responder group lysed autologous and allogeneic HNSCC in vitro, suggesting a possible effective immunotherapeutic modality in the treatment of HNSCC.

show abstract

Section: Commentmentioning

confidence: 91%

Anti-CD3/Anti-CD28 Bead Stimulation Overcomes CD3 Unresponsiveness in Patients With Head and Neck Squamous Cell Carcinoma

Shibuya

Wei

Zormeier

et al. 2000

Arch Otolaryngol Head Neck Surg

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, there has been a surge in the development of novel sutures with additional properties such as those modified with antimicrobial agents [81][82][83][84][85][86][87] bioactive molecules like DNA, 88 drugs, 89 antibodies, 90 proteins, 91-93 growth factors, [94][95][96][97][98][99] and silver 100 in an effort to customize and improve the functional outcome of sutures. After several years of research and development the first antibacterial suture Vicryl Plus (triclosan coated polyglactin 910 suture) was approved in 2002 by Food and Drug Administration (FDA), United States to reduce the risk of surgical site infections.…”

Section: Recent and Emerging Trendsmentioning

confidence: 99%

Suture materials — Current and emerging trends

Christopher

Sethu

Nayak

et al. 2016

J Biomedical Materials Res

158

108

View full text Add to dashboard Cite

Surgical sutures are used to facilitate closure and healing of surgical-or trauma-induced wounds by upholding tissues together to facilitate healing process. There is a wide range of suture materials for medical purpose and the main types include absorbable and nonabsorbable. Recently, there is a growth in the development of classes of suture materials based on their properties and capabilities to improve tissue approximation and wound closure. This review outlines and discusses the current and emerging trends in suture technology including knotless barbed sutures, antimicrobial sutures, bio-active sutures such as drug-eluting and stem cells seeded sutures, and smart sutures including elastic, and electronic sutures. These newer strategies expand the versatility of sutures from being used as just a physical entity approximating opposing tissues to a more biologically active component enabling delivery of drugs and cells to the desired site with immense application potential in both therapeutics and diagnostics.

show abstract

“…Moreover, matrix metalloproteinase‐inhibitor‐coated sutures have shown the improvement of tissue integrity during anastomotic repair . Finally, the enhancement of a TH1 immune response in patients with advanced‐stage head and neck squamous cell carcinoma have been achieved with antibody‐coated sutures (anti‐CD3/anti‐CD28) , …”

mentioning

confidence: 99%

“…5,6 Finally, the enhancement of a TH1 immune response in patients with advanced-stage head and neck squamous cell carcinoma have been achieved with antibody-coated sutures (anti-CD3/anti-CD28). 7,8 Mesenchymal stem cells (MSCs) are a useful clinical tool for treatment of many diseases and have been recently used in combination with sutures to improve the strength of adhesionfree colonic anastomoses. 9 Similar biosutures have been developed using bone marrow MSCs to reduce intraabdominal adhesions.…”

mentioning

confidence: 99%

Mesenchymal stem cell‐coated sutures enhance collagen depositions in sutured tissues

Casado

Blázquez

Jorge

et al. 2014

Wound Repair Regeneration

View full text Add to dashboard Cite

Sutures are commonly used for surgical procedures and new sutures are being developed to improve wound healing. In the past decade, it has been extensively shown that mesenchymal stem cells (MSCs) have a wound healing potential. To benefit the overall wound healing process, we aimed to analyze the usage of pretreated sutures for improving the implantation of MSCs in the tissues. Our results firstly showed that suture pretreatments with gelatin, poly-L-lysine, and NaOH improved the adhesive strength of MSCs to sutures. These cells remained surrounding the sutured tissue and no significant phenotypic changes were found in those cells cultured onto pretreated sutures. In vivo experiments showed that the implantation of MSCs by suturing increases the collagen content in the sutured tissue. Moreover, proteomics analysis of secreted proteins showed that collagen alpha-1(I) chain was the most abundant collagen found. To our knowledge, this is the first report that aimed to improve the implantation of MSCs in tissue by suture pretreatments. Moreover, in vivo experiments suggest that MSC-coated sutures may enhance wound healing and tissue remodeling through the release of different collagen types being applicable for those patients that tend to have difficulty healing.

show abstract

Anti-CD3/Anti-CD28 Monoclonal Antibody–Coated Suture Enhances the Immune Response of Patients With Head and Neck Squamous Cell Carcinoma

Cited by 21 publications

References 18 publications

Anti-CD3/Anti-CD28 Bead Stimulation Overcomes CD3 Unresponsiveness in Patients With Head and Neck Squamous Cell Carcinoma

Anti-CD3/Anti-CD28 Bead Stimulation Overcomes CD3 Unresponsiveness in Patients With Head and Neck Squamous Cell Carcinoma

Suture materials — Current and emerging trends

Mesenchymal stem cell‐coated sutures enhance collagen depositions in sutured tissues

Contact Info

Product

Resources

About