Anti-CD44 antibodies grafted immunoaffinity Fe3O4@MnO2 nanozymes with highly oxidase-like catalytic activity for specific detection of triple-negative breast cancer MDA-MB-231 cells

Evaluation of the performance of Fe 3 O 4 /MnO 2 hybrid nanozymes with doxorubicin on multicellular structure and their therapeutic management to limit the growth of human breast cancer cells

“…This effect is particularly remarkable when combined synergistically with PTT and radiotherapy, as noted by Lv et al [14] and Li et al [36]. Also, besides enhancing O 2 and °OH levels, pH-responsive Fe 3 O 4 /MnO 2 @DOX hybrid nanozymes offer a hopeful strategy for targeted drug delivery in drug-resistant cancers, ensuring e cient drug release at pH 6.5, particularly in synergistic actions, similar to the discoveries of Cheng et al [22], Meng et al [37], and Chen et al [7]. In line with ndings of Wang et al [34] and Zhu et al [38], it was discovered that Fe 3 O 4 /MnO 2 @DOX hybrid nanozymes, particularly in synergistic activity, demonstrates substantial toxicity against MCF-7 cells by promoting apoptosis through enhanced ROS.…”

“…With this premise, following the study of Fe 3 O 4 /MnO 2 @DOX hybrid nanozymes and their structural and physicochemical analysis (Figs. 2 and 3), it was discovered that these nanozymes, with improved catalytic activity, lead to a greater O 2 and °OH levels in hypoxic environments compared to non-hybrid nanozymes [7,34]. According to the ndings of Xu et al [35], it appears that increasing O 2 levels by enhancing drug permeability and increasing °OH radical through inducing apoptosis can speed up the drug resistance cancer treatment process.…”

“…To enhance the catalytic performance of Fe 3 O 4 nanozymes, the incorporation of MnO 2 nanozymes is proposed [6]. The addition of MnO 2 not only effective in Fe + 2 regeneration, but also reduces tumor hypoxia by converting H 2 O 2 to H 2 O and O 2 in acidic conditions [7].…”

“…Despite challenges like low selectivity and biocompatibility linked to MnO 2 [8], its capacity to convert superoxide into °OH and H 2 O 2 during catalysis has increased its potential for use in cancer therapy [6,7,9]. Furthermore, Fe 3 O 4 and MnO 2 nanoparticles exhibit enhanced catalytic pathways under photothermal and photodynamic therapy activities, as evidenced in studies by Du et al [10], Chen et al [11], Cun et al [12] and Zhang et al [6].…”

Nanomaterial-based biosensors for the detection of foodborne bacteria: a review

“…have simulated enzyme activity and can use molecular oxygen as electron acceptors to oxidize color developing substrates to produce visible color changes. [73][74][75][76] Zhu et al 77 prepared a label-free ultra-sensitive colorimetric aptamer sensor for the detection of S. aureus. The principle of this method is that the SA31 aptamer can be adsorbed on the surface of the octahedron Mn 3 O 4 NPs and significantly inhibit the oxidase simulation activity by blocking its electron transfer to TMB.…”