Anti-CEA immunoscintigraphy and computed tomographic scanning in the preoperative evaluation of mediastinal lymph nodes in lung cancer.

Abstract

(109 of 130), respectively. In the same analysis corresponding specificities were 54% (13 negative scans of 24 benign lesions), 80% (103 of 129), and 84% (109 of 130).Clinical studies using indium-111 labelled F(ab')2 fragments of the anti-CEA monoclonal antibody F023C5 have been carried out by our group since November 1987.7 1012 We aimed to evaluate the role of planar and single photoemission computed tomography (SPECT) immunoscintigraphy images in the thoracic assessment of resectability. The present report focuses on the preoperative evaluation of mediastinal lymph nodes which, based on our earlier studies, seemed the most fruitful field of application for immunoscintigraphy. Methods PATIENTS AND STUDY DESIGNEligible patients either had histologically proved lung cancer or were so strongly suspected of having lung cancer to be offered a diagnostic and possibly curative thoracotomy. All were considered operable after a preliminary evaluation based on history, physical examination, blood chemistry and haematological counts, bronchoscopy, lung function tests, chest radiographs and other tests, as required by the results of the above evaluation. Registered patients underwent additional mandatory investigations including anti-CEA immunoscintigraphy (both planar and SPECT images), technetium-99 labelled methylene diphosphonate bone scan, and CT scans of the thorax, upper abdomen, and brain. Other Second Pulmonary

Prognostic Value of Stage Grouping and TNM Descriptors in Lung Cancer

“…Such clinical evaluation, which also included physical examination, routine laboratory tests, and the measurement of serum tumor markers, 10,11 was supplemented by many nonroutine studies, including 104 67 Ga scans 12 and 142 anti-carcinoembryonic antigen (CEA) monoclonal antibody scintigraphies. 13,14 In contrast with several carefully staged patients, there were others for whom performing the baseline three-organ CT was impossible or unreasonable. Also, a small but significant number of patients refused to undergo what they considered a distressing test.…”

Depressive reactions to lung cancer are common and often followed by a poor outcome

“…A new staging procedure, consisting of Indium-111 anti-carcinoembryonic antigen (CEA) monoclonal antibody scintigraphy [12], was added to the evaluation of all surgical candidates. Cell types and tumour stages were classified according to internationally adopted criteria [13,14].…”

“…The trend approached statistical significance in eight circumstances (SDS items 2, 5, 7, I feel down-hearted, blue and sad Morning is when I feel the best I have crying spells or feel like it I have trouble sleeping through the night I eat as much as I used do I enjoy looking at, talking to, and being with attractive women (or men) I notice that I am losing weight I have trouble with constipation My heart beats faster than usual I get tired for no reason My mind is as clear as it used to be I find it easy to do things I used to I am restless and can't keep still I feel hopeful about the future I am more irritable then usual I find it easy to make decisions I feel that I am pretty useful and needed My life is pretty full I feel that others would be better off if I were dead I still enjoy the things I used to do 65 36 92 55 47 20 54 90 96 49 50 35 73 57 66 42 66 51 114 50 49 37 31 37 41 14 29 25 24 49 38 30 37 37 38 41 42 45 8 43 3 28 3 19 14 22 14 6 4 16 24 31 10 25 9 28 16 19 3 25 16 32 7 22 31 48 35 12 5 17 21 37 13 12 19 21 8 16 6 14 8, 12,15,18,19), being significant at p<0.0025 in one case (item 19="I feel that others would be better off if I were dead"). Dichotomizing the sample into two groups with antithetical SDS responses (i.e.…”

99mTC‐tetrofosmin scintigraphy in lung carcinoma staging and follow‐up evaluations

“…33 Unfortunately, no scintigraphic technique has been found sufficiently effective and feasible to replace the routine use of CT. 33 For example, when we studied 67m Ga scintigraphy and, later, the anticarcinoembryonic antigen monoclonal antibody scintigraphy, we obtained results that were often noteworthy but never really satisfactory. 22,23,25,[55][56][57][58][59] 99m TC-tetrofosmin is a new myocardial imaging agent with high affinity for cancer tissues. The mechanism of tumor uptake for this radiopharmaceutical is not clearly understood.…”