Anti‐Centromere Protein A Antibody Disrupts the Competence of Mouse Oocytes Matured In Vitro
Masashi Shioya,
Keiichi Takahashi,
Shun Nakano
et al.
Abstract:IntroductionAnticentromere autoantibodies are associated with refractory IVF/ET failure, but causality is unclear. Experimental models are needed.MethodsImmature oocytes collected from 23‐day‐old mice were matured in vitro for 18 h in a culture medium containing an anti‐human centromere protein A (CENP‐A) polyclonal antibody, and those oocytes’ maturity and chromosome/spindle structure were assessed.ResultsAntibody exposure did not affect the germinal vesicle breakdown ratio but reduced the first polar body fo… Show more
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