Anti-Colitic Effects of Kanjangs (Fermented Soy Sauce and Sesame Sauce) in Dextran Sulfate Sodium-Induced Colitis in Mice

Abstract

This study was conducted to investigate the preventive effects of different kanjangs (Korean soy sauces), including acid-hydrolyzed soy sauce (AHSS), fermented soy sauce (FSS), and fermented sesame sauce (FSeS), on 2% dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6J mice. The fermented sauces, particularly FSeS, significantly suppressed DSS-induced body weight loss, increased colon length, and decreased colon weight/length ratios. Histological observations suggested that the fermented sauces prevented edema, mucosal damage, and the loss of crypts induced by DSS compared to the control mice and animals fed AHSS. FSeS and FSS decreased the serum levels of tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin (IL)-6, and IL-17α. mRNA expression of these cytokines as well as that of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in colon mucosa was also inhibited by the two sauces. Our results suggest that fermented sauces, especially FSeS, exert an anticolitic effect partially by reducing the serum levels of proinflammatory cytokines and inhibiting the mRNA expression of these factors in the colon tissue of mice treated with DSS. However, AHSS did not protect against DSS-induced colitis. In addition, low-dose treatment (4 mL/kg) with the fermented sauces resulted in greater anticolitic effects than consumption of a high quantity (8 mL/kg) of the sauces.

The Fermented Soy Beverage Q-CAN® Plus Induces Beneficial Changes in the Oral and Intestinal Microbiome

“…Fermented soy consumption has been shown to be protective against the development of several diseases including type 2 diabetes [6], NAFLD [8], alcoholic induced liver damage [21], colitis [10], cardiovascular disorders and cancer [11] [2]. However, the mechanisms through which fermented soy products exert the above beneficial effects are totally unknown.…”

“…Consumption of fermented soybean foods is 4 associated with many health benefits including reduced risks of type 2 diabetes (T2D) and blood pressure [3][4][5], improved fasting blood glucose and other metabolic syndrome symptoms [6], improved plasma triglyceride levels [7] and protection against the development of insulin resistance and Non Alcoholic Fatty Liver Disease (NAFLD) [8]. In addition, fermented soy may lower inflammatory markers [9], ameliorate colitis [10] and prevent the onset and progression of cardiovascular disorders and cancer [11] [2]. However, the mechanisms through which fermented soy may exert the above effects are unknown.…”

Antioxidative effects of fermented sesame sauce against hydrogen peroxide-induced oxidative damage in LLC-PK1 porcine renal tubule cells

“…Neither daidzein nor genistein have been detected in FSS [33]. Treatment with sesamin was found to significantly decrease ROS production in H 2 O 2 -treated rat pheochromocytoma PC12 cells [41].…”

The Fermented Soy Beverage Q-CAN® Plus Induces Beneficial Changes in the Oral and Intestinal Microbiome

“…Consumption of fermented soybean foods is associated with many health benefits including reduced risks of type 2 diabetes (T2D) and blood pressure [3][4][5], improved fasting blood glucose and other metabolic syndrome symptoms [6], improved plasma triglyceride levels [7] and protection against the development of insulin resistance and Non Alcoholic Fatty Liver Disease (NAFLD) [8]. In addition, fermented soy may lower inflammatory markers [9], ameliorate colitis [10] and prevent the onset and progression of cardiovascular disorders and cancer [11] [2]. However, the mechanisms through which fermented soy may exert the above effects are unknown.…”