Anti-complementary Activity of Triterpenoides from Fruits of Zizyphus jujuba

Lee, Sang-Myung; Park, Jin Gyu; Lee, You-Hee; Lee, Cheal-Gyu; Min, Byung‐Sun; Kim, Jung-Hee; Lee, Hyeong‐Kyu

doi:10.1248/bpb.27.1883

Cited by 101 publications

(61 citation statements)

References 26 publications

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“…There were identified as 3 -trans-p-coumaroyloxy-2R-hydroxyolean-12-en-28-oic acid and 3 -cis-p-coumaroyloxy-2R-hydroxyolean-12-en-28-oic acid according to the reported literature (30,31). The molecular formula of compound 11 was inferred as C 30 H 48 O 4 on the basis of analyses of ESI-MS and 1 H and 13 C NMR spectra, suggesting it had seven unsaturated degrees in the molecule.…”

Section: Resultsmentioning

confidence: 99%

Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity

Liu

2007

J. Agric. Food Chem.

271

199

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Bioactivity-guided fractionation of apple peels was used to determine the chemical identity of bioactive constituents. Thirteen triterpenoids were isolated, and their chemical structures were identified. Antiproliferative activities of the triterpenoids against human HepG2 liver cancer cells, MCF-7 breast cancer cells, and Caco-2 colon cancer cells were evaluated. Most of the triterpenoids showed high potential anticancer activities against the three human cancer cell lines. Among the compounds isolated, 2R-hydroxyursolic acid, 2R-hydroxy-3 -{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3 -trans-p-coumaroyloxy-2R-hydroxyolean-12-en-28-oic acid showed higher antiproliferative activity toward HepG2 cancer cells. Ursolic acid, 2R-hydroxyursolic acid, and 3 -transp-coumaroyloxy-2R-hydroxyolean-12-en-28-oic acid exhibited higher antiproliferative activity against MCF-7 cancer cells. All triterpenoids tested showed antiproliferative activity against Caco-2 cancer cells, especially 2R-hydroxyursolic acid, maslinic acid, 2R-hydroxy-3 -{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3 -trans-p-coumaroyloxy-2R-hydroxyolean-12-en-28-oic acid, which displayed much higher antiproliferative activities. These results showed the triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for the anticancer activities of whole apples.

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Section: Resultsmentioning

confidence: 99%

Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity

Liu

2007

J. Agric. Food Chem.

271

199

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“…From our study it may be concluded that the low dose of MEZJ (250 mg/kg) possess good hepatoprotective activity in chronic hepatitis induced by CCl 4 whereas low and medium dose of the MEZJ (250 mg/kg and 500 mg/kg) potentially ameliorates acute hepatitis induced by CCl 4 . The protective effect may be because of the presence of flavonoids and saponins in MEZJ.…”

Section: Discussionmentioning

confidence: 65%

“…The result indicated that MEZJ was effective in low and medium doses (250 and 500 mg/kg, p.o) at times of acute stress, whereas, during chronic damage to hepatocyte, only low dose (250 mg/kg, p.o) of MEZJ is potent enough to reverse the damaging effect of hepatotoxin such as CCl 4 . On the contrary, high dose (1000 mg/kg, p.o) of MEZJ was found to be least effective in presence of damage to liver.…”

Section: Discussionmentioning

confidence: 99%

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Potency of Methanolic Extract of <I>Zizyphus jujuba</I> Fruit against Carbontetrachloride Induced Hepatic Damage in Rats

Kumar¹,

Asdaq²,

Kumar³

2010

Journal of Pharmaceutical Research

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A high percentage of the people living in developing countries use traditional medicines including medicinal herbs to meet their primary health care needs for various ailments including heapatic damage. Traditionally, the fruits of Zizyphus jujube extract have been used in Indian and Chinese system of medicine to strengthen liver function. However, there is no scientific evidence for confirming the efficacy of this herb. Hence, present study was undertaken to evaluate the effect of methanolic extract of Zizyphus jujube fruit (MEZJ) on acute (0.5 ml/kg, p.o.) and chronic (0.2 ml/kg, p.o. twice weekly for eight weeks) models of liver injury induced by carbon tetrachloride (CCl 4 ) in rats. The MEZJ was administered orally at three different doses of 250 mg/kg, 500 mg/kg and 1000 mg/kg for eight weeks and ten days in chronic and acute models, respectively. The MEZJ (250 mg/kg, p.o.) significantly decreased levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin in serum and increased the same in LTH in the chronic model. In acute liver injury, MEZJ (250 mg/kg, p.o.) and MEZJ (500 mg/kg, p.o.) altered biochemical markers in both serum and LTH indicating hepatoprotective effect. The MEZJ (250 mg/kg, p.o.) also showed significant rise in SOD and catalase activities in both chronic and acute models, while MEZJ (500 mg/kg, p.o.) caused elevation in antioxidant enzyme activities only in the acute model. The histopathological studies supported the biochemical findings. It is concluded that MEZJ possess good hepatoprotective effect at doses of 250 and 500 mg/kg orally, whereas, 1000 mg/kg was found to be non-effective in preventing the hepatic damage.

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“…jujube showed significant protection against CCl4 intoxicated HepG2 cell lines by means of increased cell viability and decreased LDH levels compared to control group. It was reported for anticancer, anxiolytic, anti-complementary and hypoglycemic activities [23][24][25][26]. Jujuba methanol extraction with different concentrations inhibited the lipid peroxidation and significantly restored the liver function markers (Ast, Alt, Alp, LDH) IN Acute liver damaged) [27].…”

Section: Magic Fruit (Ziziphus Jujube)mentioning

confidence: 99%