Anti-complementary constituents of <i>Anchusa italica</i>

Hou, Yu-zhen; Chen, Kui-Kui; Deng, Xiling; Fu, Zelong; Chen, Daofeng; Wang, Qi

doi:10.1080/14786419.2017.1320789

Cited by 22 publications

(6 citation statements)

References 21 publications

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“…The 13 C and DEPT spectra revealed the presence of 13 carbons, including two olefinic carbons at δ C 136.1 and 131.1, two oxygenated methine groups at δ C 69.5 and 65.3, three quaternary carbons of which two are oxygenated at δ C 79.0, 77.8 and δ C 40.7, two methylene groups and four methyl groups between δ C 46.5 and 24.1. The NMR data is similar to those reported in the literature for (3 S ,5 R ,6 R ,7 E ,9 S )‐3,5,6,9‐tetrahydroxymegastigm‐7‐ene [37,38] …”

Section: Resultssupporting

confidence: 87%

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Tajuddeen

Swart

Hoppe

et al. 2021

Chemistry & Biodiversity

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Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata found in KwaZulu‐Natal in South Africa was investigated for phytochemical constituents, and for antiplasmodial and cytotoxic effects. The plant leaves were collected from the University of KwaZulu‐Natal (UKZN) arboretum on the Pietermaritzburg Campus, in March 2019. The inhibitory activity against 3D7 Plasmodium falciparum was determined using the parasite lactate dehydrogenase (pLDH) assay and cytotoxicity against HeLa cells was evaluated using the resazurin assay. The bioactive compounds were isolated by chromatographic purification and their structures were established with spectroscopic and spectrometric techniques. The plant leaf extract displayed significant antiplasmodial activity at 50 μg/mL and was also cytotoxic against HeLa cells. Chromatographic purification of the extract led to the isolation of two biflavonoids, four flavonoid glycosides, a steroid glycoside, and a megastigmene derivative. The compounds displayed antiplasmodial and antiproliferative activities at 50 μg/mL but the activity was substantially reduced at 10 μg/mL. The activities and compounds are being reported in O. obovata for the first time.

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Section: Resultssupporting

confidence: 87%

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Tajuddeen

Swart

Hoppe

et al. 2021

Chemistry & Biodiversity

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“…Compounds 7 – 20 were identified as 3,4-dihydroxybenzaldehyde ( 7 ), 4-hydroxybenzaldehyde ( 8 ), isovanillin ( 9 ), 3-hydroxy-4-methoxybenzoic acid ( 10 ), 3′,4′-dihydroxyacetophenone ( 11 ), syringic acid ( 12 ), salvianolic acid A ( 13 ), methyl salvionolate A ( 14 ), caffeic acid ( 15 ), 4-hydroxycinnamic acid ( 16 ), isoferulic acid ( 17 ), methyl ( R )-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate ( 18 ), rosmarinic acid ( 19 ), and methyl rosmarinate ( 20 ), respectively, based on the comparisons of their physical data with reported values.…”

Section: Resultsmentioning

confidence: 99%

Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal PlantSalvia chinensis

Wang

et al. 2018

J. Nat. Prod.

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Six new phenolic acid derivatives, salviachinensines A−F (1−6), together with 14 known compounds (7−20) were isolated from the Chinese medicinal plant Salvia chinensis. The structures of salviachinensines A−F (1−6) were elucidated by NMR spectroscopy, bioinspired chemical synthesis, ECD analysis, and quantum chemical calculation methods. Compounds 2 and 3 are a pair of cis−trans isomers, and compounds 5 and 6 a pair of epimers. The solventinduced isomerization of compounds 5 and 6 and the hypothetical biogenetic pathway of compounds 1−6, as well as the antiproliferative property and the ability of 1 to induce apoptosis and arrest cell cycle progression of MOLM-13 cells, were also investigated.

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“…Plants are an important source of phenolic compounds, which are known for their antibacterial properties and can have applications as natural preservatives either in the food field or in the cosmetic field [4,[12][13][14]. Previous chemical studies have shown that Anchusa italic Retz is rich in polyphenols, flavonoids, saponins, tannins, vitamin E [15][16][17][18]. The seeds of the plant are rich in saturated fatty acids, unsaturated fatty acids, and alkaloids [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antioxidant Properties of Total Polyphenols of Anchusa italica Retz

et al. 2022

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Anchusa italica Retz has been used for a long time in phytotherapy. The aim of the present study was to determine the antioxidant and antibacterial activities of extracts from the leaves and roots of Anchusa italica Retz. We first determined the content of phenolic compounds and flavonoids using Folin–Ciocalteu reagents and aluminum chloride (AlCl3). The antioxidant activity was determined using three methods: reducing power (FRAP), 2.2-diphenyl-1-picrylhydrazyl (DPPH), total antioxidant capacity (TAC). The antimicrobial activity was investigated against four strains of Escherichia coli, two strains of Klebsiella pneumoniae and coagulase-negative Staphylococcus, and one fungal strain of Candida albicans. The results showed that the root extract was rich in polyphenols (43.29 mg GAE/g extract), while the leave extract was rich in flavonoids (28.88 mg QE/g extract). The FRAP assay showed a strong iron reduction capacity for the root extract (IC50 of 0.11 µg/mL) in comparison to ascorbic acid (IC50 of 0.121 µg/mL). The DPPH test determined an IC50 of 0.11 µg/mL for the root extract and an IC50 of 0.14 µg/mL for the leaf extract. These values are low compared to those for ascorbic acid (IC50 of 0.16 µg/mL) and BHT (IC50 0.20 µg/mL). The TAC values of the leaf and root extracts were 0.51 and 0.98 mg AAE/g extract, respectively. In vitro, the extract showed inhibitory activity against all strains studied, with diameters of zones of inhibition in the range of 11.00–16.00 mm for the root extract and 11.67–14.33 mm for the leaf extract. The minimum inhibitory concentration was recorded for the leaf extract against E. coli (ATB:57), corresponding to 5 mg/mL. Overall, this research indicates that the extracts of Anchusa italica Retz roots and leaves exert significant antioxidant and antibacterial activities, probably because of the high content of flavonoids and polyphenols.

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Anti-complementary constituents of Anchusa italica

Cited by 22 publications

References 21 publications

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal PlantSalvia chinensis

Antimicrobial and Antioxidant Properties of Total Polyphenols of Anchusa italica Retz

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