Anti-confocal assessment of middle ear inflammation

Jung, David S.; Crowe, John A.; Birchall, John P.; Somekh, Michael Geoffrey; See, C. W.

doi:10.1364/boe.8.000230

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…An anticonfocal system combined with spectroscopic measurements in the visible and near‐infrared range was proposed to reject unwanted signals from the TM and measure the blood content within the middle ear cavity. In a study by Jung et al, 24 the anticonfocal system measured the severity of inflammation in patients with AOM defined by an inflammation index.…”

Section: Resultsmentioning

confidence: 99%

Emerging Technologies for the Diagnosis of Otitis Media

Marom¹,

Kraus²,

Habashi³

et al. 2018

Otolaryngol.--head neck surg.

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Objective To review new experimental techniques for the diagnosis of otitis media (OM). Data Sources Literature search in English in the following databases: MEDLINE (via PubMed), Ovid Medline, Google Scholar, and Clinical Evidence (BMJ Publishing) between January 1, 2005, and April 30, 2018. Subsequently, articles were reviewed and included only if relevant. Review Methods MeSH terms: [“diagnosis”] AND [all forms of OM] AND [“human”] AND [“ear”] and [“tympanic membrane”]. The retrieved innovative diagnostic techniques rely on and take advantage of the physical properties of the tympanomastoid cavity components: tympanic membrane (TM) thickness, its translucency and compliance; middle ear fluid characteristics; biofilm presence; increased tissue metabolic activity in OM states; and fluid presence in the mastoid cavity. These parameters are taken into account to establish OM diagnosis objectively. We review spectral gradient acoustic reflectometry, digital otoscopy, TM image analysis, multicolor reflectance imaging, anticonfocal middle ear assessment, optical coherence tomography, quantitative pneumatic otoscopy, transmastoid ultrasound, wideband measurements, TM thickness mapping, shortwave infrared imaging, and wideband acoustic transfer functions. Conclusions New experimental techniques are gradually introduced to overcome the limitations of standard otoscopy. The aforementioned techniques are still under investigation and are pending widespread clinical use. The implementation of these techniques in the market is dependent on their success in clinical trials, as well as on their future cost. Implication for Practice New techniques for the diagnosis of OM can objectively evaluate the morphology of the TM, determine the presence of middle ear fluid and evaluate its content, and thus potentially replace standard otoscopy.

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Section: Resultsmentioning

confidence: 99%

Emerging Technologies for the Diagnosis of Otitis Media

Marom¹,

Kraus²,

Habashi³

et al. 2018

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

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“…Fluorescent otoscopy can highlight the presence of cholesteatoma with the potential to guide resection attempts in the future 49 . Additionally, an anti-confocal microscopy system has been proposed that may highlight inflammation of the middle ear, though this has yet to be tested in vivo 50 .…”

Section: Discussionmentioning

confidence: 99%

Shortwave infrared otoscopy for diagnosis of middle ear effusions: a machine-learning-based approach

Kashani

Młyńczak

Zarabanda

et al. 2021

Sci Rep

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Otitis media, a common disease marked by the presence of fluid within the middle ear space, imparts a significant global health and economic burden. Identifying an effusion through the tympanic membrane is critical to diagnostic success but remains challenging due to the inherent limitations of visible light otoscopy and user interpretation. Here we describe a powerful diagnostic approach to otitis media utilizing advancements in otoscopy and machine learning. We developed an otoscope that visualizes middle ear structures and fluid in the shortwave infrared region, holding several advantages over traditional approaches. Images were captured in vivo and then processed by a novel machine learning based algorithm. The model predicts the presence of effusions with greater accuracy than current techniques, offering specificity and sensitivity over 90%. This platform has the potential to reduce costs and resources associated with otitis media, especially as improvements are made in shortwave imaging and machine learning.

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Panel 1: Biotechnology, biomedical engineering and new models of otitis media

Gisselsson-Solén

Tähtinen

Ryan

et al. 2020

International Journal of Pediatric Otorhinolaryngology

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Background Eczema phenotypes and emotional and behavioural problems are highly prevalent in childhood, but their mutual relationship is not fully clear. Objectives To examine the associations of eczema phenotypes with school-age emotional and behavioural problems, and the bidirectional associations of eczema and emotional and behavioural problems from birth until 10 years. Methods This study among 5265 individuals was embedded in a prospective population-based cohort study. Never, early transient, mid-transient, late transient and persistent eczema phenotypes were identified based on parent-reported, physician-diagnosed eczema from age 6 months until 10 years. Emotional (internalizing) and behavioural (externalizing) problems were measured repeatedly using the Child Behavior Checklist from age 1Á5 to 10 years. Cross-lagged models were applied for bidirectional analyses. Results All eczema phenotypes were associated with more internalizing problems and attention problems at age 10 years, compared with never having eczema: range of Z-score differences 0Á14 [95% confidence interval (CI) 0Á01-0Á27] to 0Á39 (95% CI 0Á18-0Á60). Children with early transient eczema had more aggressive behaviour symptoms at age 10 years (Z = 0Á16, 95% CI 0Á05-0Á27). Bidirectional analysis showed that eczema at 0-2 years was associated with more internalizing and externalizing problems at ages 3-6 and 10 years, while, inversely, only internalizing problems at 0-2 years were associated with an increased risk of eczema at age 10 years. Conclusions Eczema phenotypes are very modestly associated with more somatic symptoms and attention problems at school age. Early transient eczema is associated with more aggressive behaviour symptoms. Directional effects seem to occur from early-life eczema to later-life internalizing and externalizing problems, rather than the reverse. What's already known about this topic? • Previous cohort studies using non-data-driven methods to define eczema phenotypes observed that children with early-onset and persistent eczema had a higher risk of emotional and behavioural problems in preadolescence. • Alternatively, previous cohort studies showed that children with emotional and behavioural problems had more severe eczema and eczema exacerbations in childhood. • The direction of effects between eczema and emotional and behavioural problems is not fully clear.

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Anti-confocal assessment of middle ear inflammation

Cited by 4 publications

References 14 publications

Emerging Technologies for the Diagnosis of Otitis Media

Emerging Technologies for the Diagnosis of Otitis Media

Shortwave infrared otoscopy for diagnosis of middle ear effusions: a machine-learning-based approach

Panel 1: Biotechnology, biomedical engineering and new models of otitis media

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