Based on a monthly drought index, the Standardized Precipitation Index (SPI), we investigate the multifractality of monthly drought areas in seven major regions in China from 1961 to 2012 using multifractal detrended fluctuation analysis. The results show that multifractality is evident in the monthly time series for all seven regions, but its strength varies between areas. From the numerical results, we further examine the stationarity and persistence of the time series in the seven drought areas. The characteristics of the variance of big and small fluctuations are also analyzed. The characteristics of multifractal spectra are used to distinguish the features of the singularity of all the data, as well as the large and small fluctuations and the spread of the changes of fractal patterns, and so on, in the monthly drought area time series for the different regions. Finally, we investigate the possible source(s) of multifractality in the drought series by random shuffling as well as surrogating the original series for each region.