Anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile idiopathic arthritis (JIA): Correlations with disease activity and severity of joint damage (a multicenter trial)

Omar, Aziza Sayed; Abo-Elyoun, Ihab; Hussein, Hanan; Nabih, Mohamed; Atwa, Hoda; Gad, Suzan; Emad, Yasser

doi:10.1016/j.jbspin.2012.03.008

Cited by 53 publications

(45 citation statements)

References 26 publications

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“…In addition, a study reported the development of more severe radiological damage in anti-CCP Ab-positive patients than in anti-CCP Ab-negative patients [39]. In pediatric population, numerous studies have been conducted on the Anti-CCP Ab recently [25,26,36]. Overall, RF is approximately found between 2% and 12% of JIA patients and was 11.1% in this study [22].…”

Section: Discussionmentioning

confidence: 55%

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New Provisional Classification of Juvenile Idiopathic Arthritis Applying Rheumatoid Factor and Antinuclear Antibody

2018

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Objective. Previous classification systems for juvenile idiopathic arthritis (JIA) were based on the number of joints involved and did not categorize homogenous disease entities. Therefore, JIA patients were reclassified retrospectively by applying rheumatoid factor (RF) and antinuclear antibody (ANA), which have been proven to constitute a homogenous disease entity. Methods. The medical records of JIA patients were investigated retrospectively and reclassified into six categories using the new provisional classification. The nomenclature was based on Dr. Martini's proposal in the 23rd European Paediatric Rheumatology Congress (2016) at Genoa, Italy. New categories included systemic JIA (sJIA), RF-positive JIA (RF-JIA), early-onset ANA-positive JIA (eoANA-JIA), enthesitis/spondylitis-related JIA (ESR-JIA), "other JIA", and "unclassified JIA". Results. Of a total of 262 JIA patients, 71 (27.1%) were reclassified as sJIA, 31 (11.8%) as RF-JIA, 22 (8.4%) as eoANA-JIA, 63 (24.0%) as ESR-JIA, 65 (24.8%) as "other JIA", and 10 (3.8%) as "unclassified JIA". A comparison of RF-JIA, eoANA-JIA, and ESR-JIA revealed significant differences in the gender ratio, age of disease onset, and the cumulative number and type of joints involved among the three groups. "Other JIA" comprised a significant proportion (24.8%) and warrants the need for further classification. The characteristics of the RF-positive patients were comparable to those of the anti-cyclic citrullinated peptide antibody-positive patients. The ANA positivity was lower (28.2%) than that in Western studies but showed similar clinical features. Conclusion. This is the first study applying RF and ANA to classify JIA without considering the joint counts. The six new categories include sJIA, RF-JIA, eoANA-JIA, ESR-JIA, "other JIA," and "unclassified JIA". (J Rheum Dis 2018;25:34-46)

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Section: Discussionmentioning

confidence: 55%

“…Anti-CCP Ab is also considered a strong predictive factor of RA [24]. In the pediatric population, anti-CCP Ab is associated with RF-positive polyarthritis, and more erosive disease [25,26]. It was also found to be increased in human leukocyte antigen (HLA)-DR4-positive polyarthritis in a Western study [27].…”

Section: Introductionmentioning

confidence: 99%

New Provisional Classification of Juvenile Idiopathic Arthritis Applying Rheumatoid Factor and Antinuclear Antibody

2018

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“…Similar to most countries, the most common JIA subtype in Taiwan is oligoarthritis (17). In Egypt, it has been found that the prevalence of JIA amongst 10-15 year old school children was equivalent to 3.3 per 1000 (18). Clinic based studies on the other hand appear to report lower prevalence rates -perhaps reflecting that many clinicians fail to recognize JIA and therefore these children do not make their way to medical care in large study centers, therefore underestimating the true prevalence (19).…”

Section: Discussionmentioning

confidence: 84%

“…While in recent study done by Omar et al, fifty four patients with JIA were included, thirty four were females (63 %) and twenty were males (37 %). ACCP was positive in thirteen patients (24 %), out of whom twelve patients had polyarticular onset, one patient had systemic onset (18). In our study, it has been found that ACCP antibodies were highly significant as regard the type of onset especially the polyarticular JIA in comparison to other types of JIA (P = 0.001) which supports other studies done by Quartier et al & van Rossum et al which stated that anti-CCP antibodies were higher in JIA patients with polyarticular onset compared to other subsets of JIA patients.…”

Section: Discussionmentioning

confidence: 99%

44. Anti-cyclic citrullinated peptide antibodies in children with Juvenile Idiopathic Arthritis

Hamooda¹,

Fouad

Galal

et al. 2017

Rheumatology

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Aim:The purpose of present study was to access the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with Juvenile Idiopathic Arthritis (JIA), and to investigate the clinical significance and diagnostic value of the anti-CCP antibodies in correlation with age, sex & activity.Methods: This case-control study was performed on 50 patients with JIA in addition to 40 sex and age-matched children as a control group. The participants were recruited from rheumatology Outpatient Clinic of Cairo University Specialized Pediatric Hospital. Patients were subjected to full history taking, clinical examination, routine laboratory investigations and x-rays on involved joints. Both patients and controls underwent assay of anti-CCP antibodies by AxSYM Anti-CCP IgG Microparticle Enzyme Immunoassay (MEIA) which is a semiquantitative determination of the IgG class of autoantibodies specific to cyclic citrullinated peptide (CCP) in patients' serum or plasma. Data were analyzed using Mann-Whitney U test, ANOVA, and independent-samples ttest by SPSS version 15. Results: Anti-CCP positivity was identified amongst patients with JIA, particularly those JIA patients experiencing RF positive polyarticular disease onset. Above all, it is important that anti-CCP positivity and bone erosions, degree of joint damage, and ESR levels were significantly correlated. Conclusion: Anti-CCP could be utilized as a valuable marker in the polyarticular form of JIA to direct early, and could be aggressive therapeutic intervention.

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“…The incidence and prevalence of JIA varied greatly among published reports due to methodological issues and the classification used (21). Anti-CCP antibodies were prevalent among JIA patients with polyarticular patterns compared to other disease patterns (22 (24). Osteomyelitis may occur in up to 18% of SCD patients, while septic arthritis in 7% of them according to a previous work (25).…”

Section: Seronegative Enthesopathy and Arthropathy Syndrome And Juvenmentioning

confidence: 97%

Magnetic resonance imaging features of hip disorders in an Egyptian pediatric population

et al. 2015

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Hip disorders in a pediatric population are a diagnostic challenge. The aim of the study is to assess the role of magnetic resonance imaging (MRI) in the evaluation of non-traumatic hip disorders in a series of Egyptian patients and to review the literature on the most common hip conditions. Seventy two consecutive patients [40 males (55.6%) and 32 females (44.4)] with acute onset of hip complaints unrelated to trauma or falls were recruited. All patients underwent an initial full clinical assessment and blood tests as well as contrast enhanced MRI of both hips. The most common diagnosis in this group of Egyptian patients was transient synovitis in 29 (40.3%) cases, followed by seronegative enthesopathy and arthropathy syndrome in 8 (11.1%), septic arthritis in 10 (13.9%), tuberculous arthritis in 4 (5.6%), sickle-cell disease in 7 (9.7%), complicated with septic arthritis in 3 (4.2%), transient bone marrow microenvironment (BME) in 3 (4.2%), osteomyelitis in 2 (2.8%), osteosarcoma in 2 (2.8%), sciatic nerve injury in 1 (1.4%), leukemia with BME in 1 (1.4%), coxa vara of both hips and L5/S1 facet joint ankylosis in 1 (1.4%), and a benign bone cyst in 1 (1.4%). MRI studies showed hip effusion in a total of 51 patients (70.8%), joint space narrowing in 9 (12.5%), and BME in 15(20.8%). MRI is a sensitive tool for assessing hip disorders in a pediatric population and can play an important role in both diagnosis and management of different hip disorders, irrespective of the underlying pathology.

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Anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile idiopathic arthritis (JIA): Correlations with disease activity and severity of joint damage (a multicenter trial)

Cited by 53 publications

References 26 publications

New Provisional Classification of Juvenile Idiopathic Arthritis Applying Rheumatoid Factor and Antinuclear Antibody

New Provisional Classification of Juvenile Idiopathic Arthritis Applying Rheumatoid Factor and Antinuclear Antibody

44. Anti-cyclic citrullinated peptide antibodies in children with Juvenile Idiopathic Arthritis

Magnetic resonance imaging features of hip disorders in an Egyptian pediatric population

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