Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis and Behcet's Disease

Koca, Süleyman Serdar; Akbulut, Handan; Dag, Sait; Artaş, Hakan; Işık, Ahmet Turan

doi:10.1620/tjem.213.297

Cited by 14 publications

(13 citation statements)

References 30 publications

(32 reference statements)

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“…Several studies have attempted to establish the frequency of positive anti-CCP antibody tests in BD, though findings have varied 6,9-12. Kwok, et al9 reported that one of three BD patients had positive anti-CCP tests; while Sghiri, et al10 reported one among five, and another study reported none in four 11.…”

Section: Discussionmentioning

confidence: 99%

“…In RA, anti-CCP antibodies are a more reliable diagnostic marker than IgM rheumatoid factor (RF), and may also indicate prognoses 1,3,6. Consensus between a positive anti-CCP antibody test and rheumatoid arthritis has proven to be a highly specific diagnostic criterion for RA in patients with very early joint symptoms 7.…”

Section: Introductionmentioning

confidence: 99%

“…Only a few studies, with small groups of patients, have reported the frequency of positive anti-CCP antibody tests in Behçet's disease (BD), and the results did not clearly correlate with the clinical manifestations of BD 6,9-12. In this study, we aimed to determine the prevalence of anti-CCP antibodies in a large group of Korean BD patients with and without joint involvement and to compare these findings with the prevalences of anti-CCP antibodies in patients with RA and SLE.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease

et al. 2012

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PurposeWe aimed to determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in a large group of Korean patients with Behçet's disease (BD), with and without joint involvement, and to compare these findings with the prevalences of anti-CCP antibodies in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).Materials and MethodsWe tested 189 patients with BD, 105 with RA, and 36 with SLE for anti-CCP antibodies and IgM rheumatoid factor in serum. We reviewed the medical records of patients with BD to investigate their personal and clinical characteristics as well as their laboratory test results.ResultsAnti-CCP antibodies were detected in seven of the 189 BD patients (3.7%), at a mean titer of 30.6±44.4 U/mL, in 86 of the 105 RA patients (81.9%) with a mean titer of 198.8±205.7 U/mL, and in nine of the 36 SLE patients (25%) with a mean titer of 180.4±113.9 U/mL. One of the seven anti-CCP-positive BD patients fulfilled the diagnostic criteria for both BD and RA. Five of the seven anti-CCP-positive BD patients (71.4%) had polyarticular joint involvement, and the other two patients (28.6%) had oligoarticular involvement.ConclusionWe determined the prevalence of anti-CCP antibodies in a large group of Korean BD patients with and without joint involvement. Negative anti-CCP test in patients with BD may help to differentiate BD from RA and SLE, all of which present with similar clinical features.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease

et al. 2012

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“…Anti-CCP antibodies are a more reliable diagnostic marker for RA and closely associated with the prognosis in RA patients [37]. Recently, a signiicant correlation was reported between anti-CCP antibodies and joint symptoms in patients with familial Mediterranean fever [38].…”

Section: Anti-cyclic Citrullinated Peptide (Anti-ccp) Antibodies and Bdmentioning

confidence: 99%

Joint Involvement and Synovial Histopathology in BD

Nanke¹,

Kotake²

2017

Behcet's Disease

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“…It is more specific than rheumatoid factor (RF) [9,10] and is now widely used. Anti-CCP antibodies may also be present in some diseases that present arthritis as a symptom, such as systemic lupus erythematosus, familial Mediterranean fever, Behçet's disease, and psoriatic arthritis [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Anti-Cyclic Citrullinated Peptide Frequency in Patients with Chronic Hepatitis C Virus Infection and Effect of Presence of Systemic Disease

Albayrak

Dursun

Uyanık

et al. 2012

EAJM

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Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis and Behcet's Disease

Cited by 14 publications

References 30 publications

Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease

Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease

Joint Involvement and Synovial Histopathology in BD

Anti-Cyclic Citrullinated Peptide Frequency in Patients with Chronic Hepatitis C Virus Infection and Effect of Presence of Systemic Disease

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