Anti‐Dehydration and Rapid Trigger‐Detachable Multifunctional Hydrogels Promote Scarless Therapeutics of Deep Burn

Abstract

There are issues and challenges in treating deep burns because of the long recovery time, frequent dressing changes, wound infection, and easy to form scar that influence aesthetics. Besides, some specific tissues are not suitable for large dressing coverage (e.g., face, perineum). Therefore, an ideal deep burn dressing should have good adhesion properties to fit the wound effectively, painless and quick replacement, resistant to infection, accelerate wound healing, reduce scarring and facilitate monitoring and diagnosis. Herein, an anti-dehydration and rapid-trigger multifunctional hydrogel dressing is prepared by interface reaction. The Pacrylamide-Formylboronicacid-Tannic acid (PAFT) hydrogels are prepared by a simple method on anti-dehydration elastomeric membrane, which is obtained using tannic acid as a dynamic crosslinking agent with 3-formylboronic acid and acrylamideunder UV light. The hydrogel exhibits a strong interfacial adhesion (892 J m −2 ± 65 J m −2 ), which rapidly (2 min) decreases (to 180 J m −2 ± 20 J m −2 ) when in the presence of glucose solution. The hydrogel has excellent anti-dehydration and moisturizing properties, and also exhibits superior antibacterial properties, hemostasis, and biocompatibility. This hydrogel is transparent allowing effective observation of wound transformation and therapeutics. Moreover, PAFT hydrogel accelerates the healing of deep burns and reduces scars.

Bioinspired Adhesive Antibacterial Hydrogel with Self-Healing and On-Demand Removability for Enhanced Full-Thickness Skin Wound Repair

“…So far, there are approximately 8.2 million people with wounds that are commonly caused by extensive skin trauma such as surgeries, burns, mechanical damages, and chronic diseases . However, for large-area wounds, aggressive adhesive materials generally exacerbate pain and cause trauma during removal, thus delaying the wound healing process, especially in the case where daily reapplication is needed . Wound dressing removal is reported to be the time of most pain for patients, and opioids have become an important means of wound treatment .…”

Mechanical Enhancement of the Gelatin/Poly(zinc acrylate) Hydrogel Stent in Bile

“…Owing to its distinctive softness, intrinsic biocompatibility, bioactivity, and modifiability, 1−3 hydrogel as a hydrophilic material has been widely studied in recent decades and developed as an excellent material in the biomedical field, 4−6 including soft robots, 2,7,8 drug delivery, 9−11 tissue engineering, 12 wound healing, 13 and vascular and nonvascular stents. 14,15 Hydrogels with or without bioactive molecules could be used as wound dressings and realized the acceleration of the healing of skin wounds.…”

“…14,15 Hydrogels with or without bioactive molecules could be used as wound dressings and realized the acceleration of the healing of skin wounds. 13,16 Tough hydrogels are the best candidate as a nitric oxide-eluting coating for vascular stents to suppress neointimal hyperplasia. 15 The properties and functionalities of hydrogels can be tuned over a wide range to satisfy the need for different scenarios by adjusting the composition.…”

“…Owing to its distinctive softness, intrinsic biocompatibility, bioactivity, and modifiability, − hydrogel as a hydrophilic material has been widely studied in recent decades and developed as an excellent material in the biomedical field, − including soft robots, ,, drug delivery, − tissue engineering, wound healing, and vascular and nonvascular stents. , Hydrogels with or without bioactive molecules could be used as wound dressings and realized the acceleration of the healing of skin wounds. , Tough hydrogels are the best candidate as a nitric oxide-eluting coating for vascular stents to suppress neointimal hyperplasia . The properties and functionalities of hydrogels can be tuned over a wide range to satisfy the need for different scenarios by adjusting the composition.…”

Biomimetic, self-coacervating adhesive with tough underwater adhesion for ultrafast hemostasis and infected wound healing

“…2 Recently developed hydrogel adhesives offer new possibilities to immediately close wound for fast hemostasis. [3][4][5][6][7][8][9][10][11][12][13] However, the hydration layer induced by blood or other body fluids hinders the formation of strong and long-lasting adhesion between adhesives and body tissues. 14 Additionally, hydrogel adhesives usually suffer from swelling upon exposure to water, which weakens their mechanical strength and leads to the bonding failure.…”