Anti-dementia drugs and hippocampal-dependent memory in rodents

Yuede, Carla M.; Dong, Hongxin; Csernansky, John G.

doi:10.1097/fbp.0b013e3282da278d

Cited by 74 publications

(35 citation statements)

References 163 publications

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“…Whilst memantine may show signs of inducing cognitive disruption in normal animals and humans, a number of papers have reported positive effects in preclinical models of cognitive impairment, e.g. transgenic mice engineered to overexpress amyloid proteins and lesioned rats (Creeley et al 2006;Minkeviciene et al 2004Minkeviciene et al , 2008More et al 2008;Yuede et al 2007). Also, memantine appears to provide some clinical benefit to Alzheimer's patients (Witt et al 2004).…”

Section: Memantine and Nvp-aam077mentioning

confidence: 94%

A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory

et al. 2011

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Overall, the opportunity to induce a selective cognitive deficit in attention (5CSRT) or working memory (DMTP) in the rat is limited by both the NMDAR antagonist and the dose range used. The importance of a preclinical focus on ketamine, which is used more frequently in clinical settings, is limited by the extent to which cognitive effects can be both detected and quantified using this exposure regimen within these two operant assays.

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Section: Memantine and Nvp-aam077mentioning

confidence: 94%

A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory

et al. 2011

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“…However a number of papers have reported positive effects in models of cognitive impairment such as transgenic mice mimicking some of the biochemical consequences of Alzheimer's disease and lesion-induced deficits in rats (e.g. Creeley et al 2006;Minkeviciene et al 2004Minkeviciene et al , 2008More et al 2008;Yuede et al 2007). This discrepancy between the positive effects on cognition in deficit models as opposed to the negative effects in normal animals is potentially a consequence of a hypoglutamatergic state in these animals (Parsons et al 2007).…”

Section: Comparison To Human Studiesmentioning

confidence: 98%

A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists

et al. 2010

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NMDA receptor-dependent mechanisms are requisite in the acquisition of a simple conditional discrimination and consolidation of extinction. Their role in working memory and reversal tasks appear to be less critical and potentially specific to the paradigm and NMDA receptor antagonist used. It is clearly misleading to generalise across NMDA antagonists with respect to their preclinical cognitive profile.

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“…Because hippocampal L/M is primarily affected in AD (21)(22) and because memantine has shown positive effects in mouse models of AD and is in use for moderate to severe AD (51), we determined the responses of 12 AD-related proteins to CFC. Results are shown in Fig.…”

Section: Hippocampus Nmda Receptor and Related Proteins-mentioning

confidence: 99%

“…Hippocampal-based L/M tasks, including CFC, have been used in studies of mouse models of AD to assess effects of AD mutations, the APP A␤ peptide and drug responses (22). The NMDAR antagonist, memantine, has been shown to rescue L/M deficits in mouse models of AD and has been approved for treatment of moderate AD (23,24).…”

mentioning

confidence: 99%

Protein Profiles Associated With Context Fear Conditioning and Their Modulation by Memantine

Ahmed

Dhanasekaran

Block

et al. 2014

Molecular & Cellular Proteomics

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Analysis of the molecular basis of learning and memory has revealed details of the roles played by many genes and the proteins they encode. Because most individual studies focus on a small number of proteins, many complexities of the relationships among proteins and their dynamic responses to stimulation are not known. We have used the technique of reverse phase protein arrays (RPPA) to assess the levels of more than 80 proteins/ protein modifications in subcellular fractions from hippocampus and cortex of mice trained in Context Fear Conditioning (CFC). Proteins include components of signaling pathways, several encoded by immediate early genes or involved in apoptosis and inflammation, and subunits of glutamate receptors. At one hour after training, levels of more than half the proteins had changed in one or more fractions, among them multiple components of the Mitogen-activated protein kinase, MAPK, and Mechanistic Target of Rapamycin, MTOR, pathways, subunits of glutamate receptors, and the NOTCH pathway modulator, NUMB homolog (Drosophila). Levels of 37 proteins changed in the nuclear fraction of hippocampus alone. Abnormalities in levels of thirteen proteins analyzed have been reported in brains of patients with Alzheimer's Disease. We therefore further investigated the protein profiles of mice treated with memantine, a drug approved for treatment of AD. In hippocampus, memantine alone induced many changes similar to those seen after CFC and altered the levels of seven proteins associated with Alzheimer's Disease abnormalities. Lastly, to further explore the relevance of these datasets, we superimposed responses to CFC and memantine onto components of the long term potentiation pathway, a process subserving learning and memory formation. Fourteen components of the long term potentiation pathway and 26 proteins interacting with components responded to CFC and/or memantine. Together, these datasets provide a novel view of the diversity and complexity in protein responses and interactions following normal learning. Molecular & Cellular

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Anti-dementia drugs and hippocampal-dependent memory in rodents

Cited by 74 publications

References 163 publications

A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory

A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory

A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists

Protein Profiles Associated With Context Fear Conditioning and Their Modulation by Memantine

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