Anti-depressive effects of Xiaoyaosan, Shugan and Jianpi herbal treatments: Role on the gut microbiome of CUMS rats

Liu, Xiaojie; Lv, Meng; Wang, Yaze; Qü, Ping; Li, Shunyong; Yu, Zhiyi; Qin, Xuemei

doi:10.1016/j.phymed.2021.153581

Cited by 18 publications

(8 citation statements)

References 16 publications

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“…After behaviors test feces were collected for 16S rRNA sequencing and fecal microbiota transplantation (FMT) before the mice were given nutritive semi‐solid paste containing activated carbon. The digestive system function indexes of CORT combined with CRS‐induced depression model were analyzed by measuring the gastric emptying rates (GER) and small intestinal transit rates (ITR) 22,23 . We comprehensively compared the effects of ZZCD and Verb on the depression and anxiety‐like performance, cognitive‐behavior, and gastrointestinal functions of the mice.…”

Section: Methodsmentioning

confidence: 99%

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Tian,

Wang,

Teng

et al. 2023

CNS Neurosci Ther

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BackgroundThe microbiota–gut–brain axis plays a critical role in neuropsychiatric disorders, particularly anxious depression, and attracts more attention gradually. Zhi Zi Chi decoction (ZZCD) consisting of Gardenia jasminoides J. Ellis and Glycine max (L.) Merr, is a classic formula in clinic and widely applied in anxiety and depression treatment. However, the underlying mechanisms of regulating microbiota–gut–brain axis in the treatment of anxious depression by oral administration of ZZCD remain elusive.Materials and MethodsIn this project, we clarified the origin and preparation methods of the Gardenia jasminoides J. Ellis and Glycine max (L.) Merr and examined the chemical ingredients of ZZCD by liquid chromatograph mass spectrometer. Then, corticosterone combined with chronic restraint stress was applied to establish an anxious depression model. After treated with ZZCD standard decoction, based on enzyme‐linked immunosorbent assay (ELISA), 16S rRNA technology, high‐throughput sequencing, quantitative RT‐PCR and fecal microbiota transplantation (FMT), the multiple associations between nucleus accumbens and intestinal flora in anxious depression mice were determined to clarify the mechanism of ZZCD in the treatment of anxiety and depression disorder.ResultsWe found various substances with antidepressant and antianxiety properties in ZZCD such as rosiridin and oleanolic acid. ZZCD could alleviate depressive and anxiety behaviors in anxious depression mice via regulating the disturbance of gut microbiota. Meanwhile, the bioactive compounds of ZZCD might directly active on neurodevelopment and neuroimmune‐related genes. Furthermore, the secretion of prolactin and estrogen, and interfering with mitogen‐activated protein kinase (MAPK) and tumor necrosis factor (TNF) signaling pathways were mainly involved in the multi‐target therapeutic effects of ZZCD against anxiety and depression.ConclusionsThese findings suggested that ZZCD exerts antidepressant effects pleiotropically through modulating the microbiota‐gut‐brain.

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Section: Methodsmentioning

confidence: 99%

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Tian,

Wang,

Teng

et al. 2023

CNS Neurosci Ther

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“…The relative abundance of the microbial community from phylum to genus was calculated by the original sequence, DADA2 analysis, and Vsearch analysis in QIIME2. 32 Alpha diversity within samples was assessed by Shannon, Faith-PD, Good's coverage, Simpson indices, plotting rarefaction curves, and rank abundance curves. In the beta diversity analysis, principal coordinate analysis (PCOA) and non-metric multidimensional scaling (NMDS) were used to compare the differences in species diversity among samples.…”

Section: Methodsmentioning

confidence: 99%

Microbiome-metabolomics deciphers the effects of Cistanche deserticola polysaccharides on aged constipated rats

Liu

Chen

et al. 2022

Food Funct.

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“…Oral administration of the Chinese herbal medicine Qingfei Paidu decoction regulates plasma TNFα, IL-1β, IL-18 and IL-8 levels and aids in the re-balancing of inflammatory components in the CoV-2 cytokine storm [471]. Xiaoyaosan, a classic traditional Chinese medicine containing eight Chinese herbs, has been used to treat depression for thousands of years however the bioactive components that provide neurological improvement await identification [472]. Changes in the gut microbiome of treated individuals that display clinical neurological improvement establishes a functional linkage of these herbal medications in the gut-brain axis [473].…”

Section: Flavonoids the Gut Microbiome And The Gut-brain And Gut-lung...mentioning

confidence: 99%

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

Melrose¹,

Smith²

2022

Front. Biosci. (Elite Ed)

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The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue protective properties. Phytochemicals are widely distributed in plants, herbs and shrubs used in traditional complimentary medical formulations for centuries. The bioactive components that convey beneficial medicinal effects in these complex herbal preparations are now being identified using network pharmacology and molecular docking procedures that identify their molecular targets. Flavonoids have anti-oxidant, anti-inflammatory, antiviral, antibacterial and anti-cancer properties that have inspired the development of potent multifunctional derivatised flavonoids of improved efficacy. The antiviral properties of flavonoids and the emergence of the severe acute respiratory syndrome (SARS-CoV-2) pandemic has resulted in a resurgence of interest in phytochemicals in the search for efficacious compounds that can prevent viral infection or replication, with many promising plant compounds identified. Promising semi-synthetic flavonoid derivatives have also been developed that inhibit multiple pathological neurodegenerative processes; these offer considerable promise in the treatment of diseases of cognitive decline. Clinical trials are currently being undertaken to evaluate the efficacy of dietary supplements rich in flavonoids for the treatment of virally-mediated diseases. Such trials are expected to identify flavonoids with cell and tissue protective properties that can be harnessed in biomedical applications that may serve as supportive adjunctive procedures to conventional anti-viral drug therapies against diseases such as COVID-19.

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Anti-depressive effects of Xiaoyaosan, Shugan and Jianpi herbal treatments: Role on the gut microbiome of CUMS rats

Cited by 18 publications

References 16 publications

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Microbiome-metabolomics deciphers the effects of Cistanche deserticola polysaccharides on aged constipated rats

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

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