Anti-dermatophytic activity of marine sponge, Sigmadocia carnosa (Dendy) on clinically isolated fungi

Dhayanithi, Nagarajan Balachandran; Kumar, TT Ajith; Kalaiselvam, Murugaiyan; Balasubramanian, T.; Sivakumar, N.

doi:10.1016/s2221-1691(12)60111-7

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…These were mainly bacteria: Acinetobacter, Aeromonas, Alcaligenes, Bacillus, Chromobacterium, Enterococcus, Pantoea, and Pseudomonas. Some sponges also show this kind of activity [107]. Dhayanithi et al [107] showed that Sigmadocia carnosa has active metabolites against four dermatophytic fungi: Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum and Microsporum gypseum.…”

Section: Discussionmentioning

confidence: 99%

Maritime environment health risks related to pathogenic microorganisms in seawater

Richard

Pougnet

Allio

et al. 2018

International Maritime Health

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Section: Discussionmentioning

confidence: 99%

Maritime environment health risks related to pathogenic microorganisms in seawater

Richard

Pougnet

Allio

et al. 2018

International Maritime Health

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“…The emerging resistance to conventional antifungals, the limited number of drugs available, and because these superficial mycoses require long periods of topical and systemic treatment, sometimes associated with adverse effects, contraindications, and interaction with other drugs, it is essential to screen for novel antifungal compounds. Natural compounds with antifungal activities have also received considerable attention during the past few decades, namely from terrestrial plants and seaweeds [27][28][29][30][31]. Due to the increasing number of fungal infections, the objective of the present work was to isolate and characterize C. jubata and F. vesiculosus pigments and extracts and to evaluate the pigments' antifungal effect against fungi agents of skin infections.…”

Section: Introductionmentioning

confidence: 99%

Seaweed Calliblepharis jubata and Fucus vesiculosus Pigments: Anti-Dermatophytic Activity

Gomes,

Cotas,

Fernandes

et al. 2024

Applied Sciences

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Seaweeds have been explored as a natural resource of compounds of interest due to their bioactivities. Although many studies report the interest and the application of seaweeds in various areas, from food or human health to the economy, these data mostly focus on raw extracts and not on specific compounds, such as seaweed pigments. Fungal infections of the skin, nails, and hair caused by dermatophytes are the most common fungal infections worldwide. These pathologies require long periods of topical and/or systemic treatment associated with adverse effects and increased antifungal resistance. So, this study had two objectives: the first was to isolate and characterize the pigments of the seaweeds Calliblepharis jubata and Fucus vesiculosus; the second was to assess their antifungal activity. The extraction of pigments was performed using a method of extraction by exhaustion, and the purification was achieved via column chromatography. Three techniques were used to characterize the pigments: thin-layer chromatography (TLC), UV–visible spectrophotometry, and Fourier-transform infrared spectroscopy (FTIR). The antifungal activity against the three most common dermatophytes, Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporum canis, was evaluated using a microdilution methodology, following the EUCAST international standards. It was possible to observe that the extracts obtained from the seaweed C. jubata, corresponding to the purified pigment phycobiliprotein, and the crude extract (an enriched extract) showed antifungal activity against the three fungal agents of human skin infection.

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“…The dermatophytes infections have considerably grown, even in immunocompetent hosts [29]. Natural compounds with antifungal activities have also received considerable attention during the past few decades, namely from terrestrial plants and seaweeds [29,31]. Due to the increasing number of fungal infections, the emerging resistance to the traditional antifungals, the limited number of antifungals available, and because superficial mycosis and onychomycoses require long periods of topical and systemic treatment that are associated to adverse effects, contraindications, and sometimes interaction with other drugs, it is essential to screen for novel antifungal compounds.…”

Section: Introductionmentioning

confidence: 99%

Seaweeds <em>Calliblepharis jubata</em> and <em>Fucus vesiculosus</em> Pigments: Antidermatophytic Activity

Gomes,

Cotas,

Fernades

et al. 2023

Preprint

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Seaweeds have been the target of much attention due to the known bioactivities of some of their compounds. Although many studies about the application of seaweeds in various areas are available, these data are mostly about the raw extracts and not about specific compounds, such as seaweeds pigments. Moreover, the fungal infections of the skin, nails and hair caused by dermatophytes, are the most common fungal infections in humans. These pathologies require long periods of topical and/or systemic treatment that are associated with adverse effects and contraindications. This study had two objectives, the first was to evaluate the possibility of isolating and characterizing the pigments of Calliblepharis jubata and Fucus vesiculosus; the second was to assess their antifungal activity. The extraction of pigments was performed using a method of extraction by exhaustion; the purification was carried out by column chromatography. Three techniques were used to characterize the pigments, thin layer chromatography (TLC), UV-visible spectrophotometry and Fourier-transform infrared spectroscopy (FTIR). The antifungal activity was evaluated using the micro-dilution method, following the EUCAST international standards, on three dermatophytes, Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum canis. It was possible to observe that the extract obtained from the seaweed C. jubata and F. vesiculosus, corresponding to the purified pigment phycobiliprotein, and the crude extract, an enriched extract, obtained from the seaweed C. jubata showed antifungal activity against the three fungal agents of human skin infection.

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Anti-dermatophytic activity of marine sponge, Sigmadocia carnosa (Dendy) on clinically isolated fungi

Cited by 8 publications

References 19 publications

Maritime environment health risks related to pathogenic microorganisms in seawater

Maritime environment health risks related to pathogenic microorganisms in seawater

Seaweed Calliblepharis jubata and Fucus vesiculosus Pigments: Anti-Dermatophytic Activity

Seaweeds <em>Calliblepharis jubata</em> and <em>Fucus vesiculosus</em> Pigments: Antidermatophytic Activity

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