Anti-Diabetes Components in Leaves of Yacon

Abstract

The inhibitory effect of four new compounds (smallanthaditerpenic acids A-D) previously isolated from leaves of Smallanthus sonchifolius (yacon) on a-glucosidase were examined and their IC 50 were determined to be 0.48, 0.59, 1.00, and 1.17 mg/mL respectively. In addition, a rapid, reliable HPLC method for the analysis of smallanthaditerpenic acids A and C in yacon leaves was established, and the variation in their contents in leaves from plants cultivated in different places and collected at different times of the year were compared. The established analytical method for determining smallanthaditerpenic acids A and C presented good results and could be used as a method for the quality control of S. sonchifolius leaves.

Phytochemical Screening, Antiglycation and Antioxidant Activities of Ethanolic Leaf Extract of Azima Tetracantha Lam.

“…According to previous study [30] , our investigation reported that Ethanol extracts highly inhibited α-amylase and α-glucosidase and this result can, at least partially, explain the traditional useof A. tetracantha leaves for treating hyperglycemia.…”