Anti-diabetic activity in type 2 diabetic mice and α-glucosidase inhibitory, antioxidant and anti-inflammatory potential of chemically profiled pear peel and pulp extracts (Pyrus spp.)

Wang, Tingting; Li, Xia; Zhou, Bin; Li, Hongfa; Zeng, Jie

doi:10.1016/j.jff.2014.12.049

Cited by 94 publications

(56 citation statements)

References 39 publications

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“…The strongest activity for leaves may be explained by the higher concentration of phenolics in the extract. This is in accordance with results of several authors who reported a linear correlation of α‐glucosidase inhibitory effects with phenolics composition . Moreover, the extract from leaves had very high concentrations of chlorogenic and caffeic acids and they were reported, by some researchers, as antidiabetic agents , .…”

Section: Results and Disscussionsupporting

confidence: 92%

A new source for developing multi‐functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.

Cvetanović

Zeković

Švarc‐Gajić

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSION Results obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against α‐amylase, α‐glucosidase and tyrosinase, and the results showed the anti‐diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A‐549; LS‐174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58–8.10 μg mL‐1. Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto‐pharmaceuticals and functional food ingredients. © 2017 Society of Chemical Industry

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Section: Results and Disscussionsupporting

confidence: 92%

A new source for developing multi‐functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.

Cvetanović

Zeković

Švarc‐Gajić

et al. 2017

J of Chemical Tech & Biotech

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“…The inhibition of α-amylase and α-glucosidase is one of the main strategies for managing hyperglycemia (Wang et al, 2015;Zengin et al, 2014). Comparison of both plant extracts showed that ALB is more potent in inhibiting α-amylase and α-glucosidase than ALT.…”

Section: Rsd (%) Addedmentioning

confidence: 99%

A comparative study of Bulgarian and Turkish Asphodeline lutea root extracts: HPLC–UV profiles, enzyme inhibitory potentials and anti-proliferative activities against MCF-7 and MCF-10A cell lines

Lazarova

Zengin

Bender

et al. 2015

Journal of Functional Foods

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“…From these results, it is obvious that CSP and CSS are 2 different cultivars in chemical composition. And they are different from other pear shaped fruits in Rosaceae that peels always contain higher TPc, TFc, and TTc (Li and others , ; Wang and others ).…”

Section: Resultsmentioning

confidence: 76%

“…It was worth mentioning that flesh of both CSP and CSS contained remarkable higher chlorogenic acid while peel, flesh, and endocarp of CSS contained higher p ‐coumaric acid and ferulic acid. Chlorogenic acid, p ‐coumaric acid, and ferulic acid were good agents, which possess many important potential bioactivities including antioxidant, antitumor, antidiabetic, and immune system enhancing activities (Krakauer, ; Wang and others ).…”

Section: Resultsmentioning

confidence: 99%

“…These wasted parts were placed at a selected place directly without any processing, it would result in a great waste of these good resource. Generally speaking, these wasted parts of fruits, including peels and endocarps, always possess more phenolics, triterpenes, flavonoids, and dietary fiber than flesh for many fruits, such as apple, hawthorn, and pear (Henríquez and others ; Li and others , ; Wang and others ). Therefore, researchers become interested in making full use of these wasted parts of fruits, which can be seen as new sources of phenolics, triterpenes, and flavonoids.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition and Bioactivities of Two Common Chaenomeles Fruits in China: Chaenomeles speciosa and Chaenomeles sinensis

Miao

Zhao

et al. 2016

Journal of Food Science

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Contents of total flavonoids, total phenolics, total triterpenes, total condensed tannin and total saponins in peels, flesh and endocarps of Chaenomeles speciosa (CSP) and Chaenomeles sinensis (CSS) were determined by colorimetric method, while 5 phenolics (vanillic, gallic, chlorogenic, ferulic and p-coumaric acids), 2 triterpenes (oleanolic and ursolic acids), and 3 flavonoids (rutin, catechin and epicatechin) were identified and quantified by high-performance liquid chromatography-mass spectrometry (HPLC-MS) and HPLC, and antioxidant and α-glucosidase inhibitory activities of them also were evaluated as well as their digestive characteristics. In the correlation analysis, total phenolics, vanillic acid, catechin, ursolic acid and oleanolic acid all contribute to DPPH(·) scavenge capacity, gallic acid contributes to total ferric reducing antioxidant power, while total triterpenes, total saponins, chlorogenic acid and ferullic acid contribute to α-glucosidase inhibitory activity. In the principal component analysis, endocarps of CSP and CSS both show better quality than their peels and flesh, respectively. In vitro digestion can increase contents of total flavonoids, total condensed tannin and total saponins, while contents of total phenolics and total triterpenes decreased greatly. Our study would contribute to the full use of discarded parts of the 2 Chaenomeles and be helpful to establish a good foundation for further research of CSP and CSS.

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Anti-diabetic activity in type 2 diabetic mice and α-glucosidase inhibitory, antioxidant and anti-inflammatory potential of chemically profiled pear peel and pulp extracts (Pyrus spp.)

Cited by 94 publications

References 39 publications

A new source for developing multi‐functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.

A new source for developing multi‐functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.

A comparative study of Bulgarian and Turkish Asphodeline lutea root extracts: HPLC–UV profiles, enzyme inhibitory potentials and anti-proliferative activities against MCF-7 and MCF-10A cell lines

Chemical Composition and Bioactivities of Two Common Chaenomeles Fruits in China: Chaenomeles speciosa and Chaenomeles sinensis

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