Anti-diabetic activity of flowers of Hibiscus rosasinensis

Venkatesh, Sama; Thilagavathi, J.; sundar, D. Shyam

doi:10.1016/j.fitote.2007.06.015

Cited by 54 publications

(34 citation statements)

References 6 publications

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“…The FBS of all the rats was measured at 0, 1, 3, 6, and 24 h post drug or extract treatment using an auto analyzer (AccuCheck Advantage II Õ , Roche, Branford, CT) glucose kit. The blood samples were collected from the tail vein after a snip (Vinkatesh et al, 2008).…”

Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Ezeja

Anaga

Asuzu

2014

Pharmaceutical Biology

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Context: Gouania longipetala Hemsl. (Rhamnaceae) is used in folkloric medicine for treating diabetes mellitus and its associated symptoms. Objective: This study evaluated the antidiabetic antilipidemic and antioxidant activities of the plant methanol leaf extract. Materials and methods: Diabetes was induced in rats by intraperitoneal injection of alloxan monohydrate (160 mg/kg). Three test doses (50, 100, and 150 mg/kg) of G. longipetala extract (GLE) were administered orally and the effects were compared with glibenclamide (2 mg/kg). The effect of GLE on hyperglycemia and sub-acute study for 21 d were carried out using its effect on fasting blood sugar (FBS) level. Serum biochemistry and antioxidant activity were evaluated. Histopathological evaluation of the pancreas was also done. Results: The LD 50 of G. longipetala was found to be 44000 mg/kg. The extract significantly (p50.0001) decreased the FBS levels of treated rats from 16.2 ± 2.03 to 6.5 ± 1.52 mM/L at 150 mg/kg within 24 h. The extract decreased FBS levels of rats by 62.0, 74.8, and 75.0% on day 21 at 50, 100, and 150 mg/kg, respectively. GLE reduced the level of malondiadehyde from 23.0 ± 1.34 to 10.3 ± 0.43 mg/dL, increased superoxide dismutase activities from 2.97 ± 0.34 to 5.80 ± 0.53 IU/L at 150 mg/kg, and improved the serum lipid profile of treated rats. GLE also caused restoration of the altered histopathological changes of the pancreas. Discussion and conclusion: Gouania longipetala demonstrated significant antidiabetic, antilipidemic, and antioxidant activities that may be due to its multiple effects involving both pancreatic and extra-pancreatic mechanisms.

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Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Ezeja

Anaga

Asuzu

2014

Pharmaceutical Biology

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“…One group served as a control which received vehicle alone. The diabetic rats (glucose level > 150 mg/dl) were separated and divided into four different groups for experimental study 7 .…”

Section: Hypoglycemic Activitymentioning

confidence: 99%

Untitled

2013

IJPSR

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“…[4][5][6][7][8][9] Hibiscus rosa-sinensis is reported to contain flavanoids like Hibiscitin and mentioned to possess antidiabetic, several other Pharmacological activities such as antihepatotoxic, antioxidant and hypolipidemic. [10][11][12][13][14][15] Quercetin possesses significant AR inhibitory and AD activities. 16,17 Aminoguanidine well known to be an AGE inhibitor and AD agent were taken as the reference compounds for the study.…”

Section: Introductionmentioning

confidence: 99%

Aldose reductase and advanced glycation end products formation inhibitory activity of standardized extracts of Picrorhiza kurroa (Royle ex benth) and Hibiscus rosa-sinensis (Linn.)

Santhosh¹,

Veeresham²,

Rao³

2017

PBE

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Objective: The objectives were to study the in-vitro and in-vivo aldose reductase and in-vitro advanced glycation end products formation inhibitory activities of the standardized extracts of Picrorhiza kurroa roots and Hibiscus rosa-sinensis flowers. Methods:In-vitro Aldose reductase inhibitory activity was studied by using isolated rat lens and kidney Aldose reductase by UV-Visible spectro photo metric method by using Quercetin as reference compound. In-vivo Aldose reductase inhibitory activity was evaluated by using experimental rat models of galactosemia and the final lens galactitol was evaluated by High performance liquid chromatography and Gas chromatography methods by using Quercetin as reference compound. Invitro advanced glycation end products formation inhibitory activity was estimated by using laboratory test reaction with protein and sugars by spectro fluorimetric method by sung aminoguanidine as reference compound. Statistical analysis of the results was done by using Analysis of the variance method. Results:The plant extracts were found to possess significant aldose reductase and advanced glycation end products formation inhibitory activity. Conclusions:More study is required for isolation and characterization of the chief chemical constituents responsible for the biological activity of the plant extracts.

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Anti-diabetic activity of flowers of Hibiscus rosasinensis

Cited by 54 publications

References 6 publications

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

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Aldose reductase and advanced glycation end products formation inhibitory activity of standardized extracts of Picrorhiza kurroa (Royle ex benth) and Hibiscus rosa-sinensis (Linn.)

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