Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats

Abstract

The present study was aimed to evaluate the anti-diabetic potential of Terminalia chebula (T. chebula) fruits on streptozotocin (STZ)-induced experimental diabetes in rats. Oral administration of ethanolic extract of the fruits (200 mg/kg body weight/rat/day) for 30 days significantly reduced the levels of blood glucose and glycosylated hemoglobin in diabetic rats. Determination of plasma insulin levels revealed the insulin stimulating action of the fruit extract. Also, the alterations observed in the activities of carbohydrate and glycogen metabolising enzymes were reverted back to near normal after 30 days of treatment with the extract. Electron microscopic studies showed significant morphological changes in the mitochondria and endoplasmic reticulum of pancreatic β cells of STZinduced diabetic rats. Also, a decrease in the number of secretory granules of β-cells was observed in the STZinduced diabetic rats and a these pathological abnormalities were normalized after treatment with T. chebula extract. The efficacy of the fruit extract was comparable with glibenclamide, a well known hypoglycemic drug.

Effects of aqueous extract of <i>Fadogia agrestis</i> stem in alloxan-induced diabetic rats

“…The decrease in the organ-body weight ratio caused by alloxan in this study may be due to atrophy which is one of the consequences of diabetic condition (Szkudelski, 2001). Specifically, the reduction in the weight of the pancreas may be due to decreased secretory granules which is similar to the findings of Kumar et al (2006) that reported a decrease in the number of secretory granules of the β-cells of the pancreas in diabetic rats The ability of the aqueous extract of F. agrestis stem to reverse the decreased organ/body weight ratio of the diabetic experimental animals further corroborate the positive influence on weight loss normally associated with diabetes (Yakubu et al, 2010).…”

Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats

“…A previous study showed that the antihyperglycemic effect of T. chebula was due to an increase in insulin level suggesting its insulinogenic activity due to stimulation of insulin secretion from remnant β cells or from regeneration of β cells (Chattopadhyay, 1999;Pari & Latha, 2002;Kumar et al, 2006). From these results, it can not be ignored that CA increases secretory β cells in islets and reduces blood glucose level in diabetic control and DNC rats.…”

“…(Combretaceae), native to India and Southeast Asia, has been used traditionally to treat various diseases (Lee et al, 2007). In the modern era it has been used as a cytoprotective (Saleem et al, 2002), antidiabetic (Murali et al, 2004;Kumar et al, 2006), renoprotective (Rao & Nammi, 2006), antioxidant (Sabu & Kuttan, 2002;Naik et al, 2004), and cardioprotective (Suchalatha & Devi, 2005).…”

Protective effect of phloretin on hyperglycemia mediated oxidative stress in experimental diabetic rats

“…Streptozotocin has been widely used for inducing diabetes in experimental animals through its toxic effects on pancreatic β-cells [30,31]. The cytotoxic action of STZ is associated with the generation of ROS causing oxidative damage [32,33].…”