Anti-diabetic activity of Holothuria thomasi saponin

Barky, Amira Ragab El; Hussein, S.; Alm-Eldeen, Abeer A.; Hafez, Y.; Mohamed, Tarek M.

doi:10.1016/j.biopha.2016.10.002

Cited by 59 publications

(47 citation statements)

References 34 publications

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“…It was associated with an increased amount of glycogen stored in liver. Morphological studies revealed that rats given the saponin extract had less pronounced degenerative alterations in pancreas β-cells [ 150 ]. Some research studies have focused on the influence of saponins on various links in diabetic pathogenesis.…”

Section: Anti-diabetic and Glucose Lowering Activitymentioning

confidence: 99%

Pharmacological Potential of Sea Cucumbers

Khotimchenko

2018

IJMS

136

103

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This review presents a detailed analysis of published research data focused on the pharmacological activity exerted by biologically active compounds isolated from sea cucumbers belonging to the class of Holothuroidea, phylum Echinodermata. The review contains descriptions of the structure, physico-chemical properties and pharmacological effects of these active substances. Particular attention is given to compounds with anticoagulant, antithrombotic, antioxidant, anticancer, anti-infectious, immune-stimulating and anti-ACE (angiotensin converting enzyme) activities as well as to the substances exerting a regulating influence on lipid and carbohydrate metabolism. All these compounds may be considered as prototypes for development of new pharmaceutical substances and medicines.

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Section: Anti-diabetic and Glucose Lowering Activitymentioning

confidence: 99%

Pharmacological Potential of Sea Cucumbers

Khotimchenko

2018

IJMS

136

103

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“…[1] [2] Globally, it is estimated that approximately 422 million people are living with diabetes and this number is envisaged to be doubled by 2030. Diabetes mellitus is triggered as a result of insufficiency insulin secretion, insulin action or both.…”

Section: Introductionmentioning

confidence: 99%

“…Diabetes mellitus is triggered as a result of insufficiency insulin secretion, insulin action or both. [1] [2] Globally, it is estimated that approximately 422 million people are living with diabetes and this number is envisaged to be doubled by 2030. [3] [4] The clinical symptoms of diabetes mellitus are presented as weight loss, polyuria, thirst, blurring of vision, and complication of renal failure, neuropathy, foot ulcers, and prolong illness will lead to microvascular and macrovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro α‐Amylase and α‐Glucosidase Inhibitory Potentials of 14 Medicinal Plants Constituted in Thai Folk Antidiabetic Formularies

Somtimuang

Olatunji

Ovatlarnporn³

2018

Chemistry & Biodiversity

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The sporadic increase in the occurrence and prevalence of diabetes mellitus have compelled and vigorous search for alternative anti-diabetic therapeutic approach from medicinal plants and its bioactive. One of the major approach employed is the reduction of gastrointestinal glucose levels through the inhibition of carbohydrate digesting enzymes notably α-amylase and α-glucosidase. In this study, the ethanol extracts of 14 selected plants from Mor Porn's recipe were screened for their α-amylase and α-glucosidase inhibitory activity. The ethanolic extract from the stem of Vitex glabrata displayed the highest percentage inhibitory activity of 84.98 ± 0.59 and 84.71 ± 1.51 against α-glucosidase and α-amylase enzymes, respectively. Chemical investigation of the active extract of V. glabrata indicated that pentacyclic triterpenes were the major compounds responsible for the activity. The result obtained from this study suggests the potential use of V. glabrata as an alternative natural source for the treatment of diabetes mellitus.

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“…Recent estimate have approximated that 451 million people have diabetes and this value is expected to increase to 693 million by the year 2045 (Cho et al, 2018). It is characterized by high glucose level in the blood due to defects in insulin action or insulin secretion, or a combination of both (Amira et al, 2016;Olatunji, Chen, & Zhou, 2017).…”

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confidence: 99%

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

et al. 2019

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In this present study, rhinacanthins‐rich extract (RRE) and rhinacanthin C (RC) the main bioactive constituent of Rhinacanthus nasutus was investigated for their protective effect against diabetic nephropathy (DN). Diabetes was induced by administering nicotinamide (100 mg/kg, i.p.)/streptozotocin (60 mg/kg, i.p.) and diabetic rats were orally administered with RRE and RC for 4 weeks. RRE and RC significantly reduced the kidney index, renal oxidative stress markers, and pro‐inflammatory cytokines. Furthermore, RRE and RC increased renal levels of glutathione, superoxide dismutase, catalase, and attenuated diabetic induced renal damages. In conclusion, RRE and RC confer protective effect against DN through the inhibition of oxidative stress and inflammation and could be a potential medicinal or nutritional supplement for the prevention of DN. Practical applications Rhinacanthus nasutus is a medicinal plant that is extensively used in Thai traditional medicine as an antibacterial, antifungal, antidiabetic, and anti‐inflammatory agent. The plant is rich in naphthoquinones, which confer it with several excellent bioactivities. The rich extract of the leaves was prepared with three major bioactive components and the extract was evaluated for its renoprotective effect in diabetic rats. The results from this study provides valuable pharmacological information that supports the use of the plant, especially the rich extract in the prevention and treatment of diabetes and diabetic complications.

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Anti-diabetic activity of Holothuria thomasi saponin

Cited by 59 publications

References 34 publications

Pharmacological Potential of Sea Cucumbers

Pharmacological Potential of Sea Cucumbers

Evaluation of In Vitro α‐Amylase and α‐Glucosidase Inhibitory Potentials of 14 Medicinal Plants Constituted in Thai Folk Antidiabetic Formularies

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

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