Anti-diabetic activity of peony seed oil, a new resource food in STZ-induced diabetic mice

Abstract

This study was conducted to investigate the components of a new resource food in China, peony seed oil (PSO) by GC-MS (gas chromatography-mass spectrometry), its inhibitory effects on carbohydrate hydrolyzing enzymes in vitro and its anti-diabetic effects on mice induced by streptozotocin (STZ). The results showed that peony seed oil showed weak anti-α-amylase activity; however, strong anti-α-glucosidase activity was noted. The GC-MS analysis of the oil showed 9 constituents of which α-linolenic acid was found to be the major component (38.66%), followed by linoleic acid (26.34%) and oleic acid (23.65%). The anti-diabetic potential of peony seed oil was tested in STZ induced diabetic mice. Administration of peony seed oil and glibenclamide reduced the blood glucose level and the area under curve (AUC) in STZ induced diabetic mice. There were significant increases in body weight, liver glycogen content, serum insulin level, high-density lipoprotein cholesterol (HDL-C) and decreases in glycosylated hemoglobin (HbA1C), total serum cholesterol (TC), and triglyceride (TG) in test groups as compared to the untreated diabetic groups. In vivo antioxidant studies on STZ induced diabetic mice revealed the reduction of malondialdehyde (MDA) and increase of glutathione peroxides (GSH-px), superoxide dismutase (SOD), and glutathione (GSH). The results provided a sound rationale for future clinical trials of oral administration of peony seed oil to alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice.

Hypolipidemic Activity of Peony Seed Oil Rich in α‐Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid β‐Oxidation

“…In 2011, at China, peony seed oil (PSO) was declared as a new resource food for high level of α‐linolenic acid (≥38%, Ministry of Health 2011 Number 9 China), Li compared fatty acids in 60 tree peony cultivars, the result indicated that the ratio of n‐6/n‐3 was between 0.4 and 1.6 and the ratio of n‐3/ total fatty acids was greater than 38% (Li and others ). The antidiabetic activity of PSO has been verified in our previous report (Su and others ), however no reports are available on the hypolipidemic effects of PSO used as dietary supplement in rats fed with high fat diet.…”

Studies on the Antidiabetic and Antinephritic Activities ofPaecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats

“…Enzymatic antioxidants, such as SOD and GSH-Px, have been considered as primary enzymes since they were involved in the direct elimination of reactive oxygen species (ROS) [ 44 ]. MDA is thought to be an indicator of the lipid peroxidation process [ 45 ]. Four-week PHC administration has successfully normalized the disordered levels of SOD, GSH-Px, and MDA in kidney of diabetic rats.…”

Process optimisation of microwave‐assisted extraction of peony (Paeonia suffruticosa Andr.) seed oil using hexane–ethanol mixture and its characterisation

“…Linoleic acid, oleic acid and linolenic acid are responsible for antioxidant function, reduces blood fat and cholesterol and prevents head blood vessel diseases. Linolenic acid also has the effect of anti-inflammatory, improving intelligence and vision (Bourourou et al, 2016), but it cannot be synthesised in the human body (Sevim et al, 2013;Su et al, 2015).…”