Anti-diabetic Activity on Ethanolic Extracts of Fruits of Terminalia chebula Retz. Alloxan Induced Diabetic Rats

Kannan, V. Rajesh; Rajasekar, Gutha; Rajesh, P.; Balasubram, V.; Ramesh, N; Solomon, E. King; Nivas, D.; Chandru, Swetha

doi:10.3923/ajdd.2012.135.142

Cited by 34 publications

(16 citation statements)

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“…Antidiabetic and renoprotective activity T. chebula fruit and seeds exhibited dose dependent reduction in blood glucose of streptozotocin induced diabetic rats both in short term and long term study and also had renoprotective activity [45,46] .…”

Section: Cytoprotective Activitymentioning

confidence: 99%

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

262

180

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Section: Cytoprotective Activitymentioning

confidence: 99%

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

262

180

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“…It has five lines or five ribs on the outer Page 3 of 27 A c c e p t e d M a n u s c r i p t skin. The fruits of T. chebula are reported to have hepatoprotective activity against CCl 4 and tertbutyl hydroperoxide [5], cytoprotective [6], antidiabetic [7,8], antioxidant [9], antibacterial [10,11], anti-arthritic [12], hypo-cholesterelomic [13] and anti-inflammatory activities [14].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of polyphenolic extract ofTerminalia chebulaRetzius fruits

Saha

Verma

2016

Journal of Taibah University for Science

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The purpose of the present study was to investigate the in vitro antioxidant activities of polyphenolic extract of fruits of Terminalia chebula Retzius (Combretaceae). The polyphenolic extract of T. chebula fruits was evaluated for antioxidant activity by determining reducing power assay, total antioxidant capacity, DPPH radical (IC 50 14 µg/mL), nitric oxide radical (IC 50 30.51 µg/ml) and hydrogen peroxide scavenging assay (IC 50 265.53 µg/ml) under in vitro conditions. Moreover the phytochemical characterization of the extract was also measured by determining total phenolic, flavonoids, tannin and ascorbic acid contents. The characterization of the extract was also done by HPLC profiling with standard gallic acid. The present study demonstrated that extract have significant reducing capacity and scavenging of nitric oxide as well as hydrogen peroxide induced radicals. This activity of the extract may be due to the total polyphenolic contents present in it. The antioxidant activity of the extract was more significant than standard

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“…Antibacterial, hypoglycemic [53,71] aqueous extract (fruits) evaluated for its antidiabetic activity in STZ-induced mild diabetic rats and compared with tolbutamide. Oral administration of effective (dose 200 mg/kg body weight) of aqueous extract of T. chebula daily once for 2 months reduced the elevated blood glucose by 43.2% and significantly reduced the increase in HbA1c.…”

Section: Terminalia Chebulamentioning

confidence: 99%

Unani Formulations for Management of Diabetes: An Overview

Hamiduddin¹

2018

IJGP

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Diabetes is a leading cause of death. In India, total number of diabetic patients is expected to be 79.4 million in 2030. It is a multifactorial disease leading to several complications. Traditional medicines are being looked up once again for its treatment; the WHO also recommended its further investigation. In this review, these drug its pharmacological activity and its formulation in Greco-Arab or Unani Medicine in India is explored. Singledrug used in formulation with reported anti-diabetic and related beneficial property are Gymnema sylvestre, Azadirachta indica, Aloe vera, Momordica charantia, Acacia arabica, Eugenia jambolana, Trigonella foenum graecum, Punica granatum, etc. Phytomedicine used in Unani medicine presents an exciting opportunity for the development of new types of therapeutics for diabetes mellitus with a holistic approach, which includes various photochemical groups such as alkaloids, terpenes, and phenolics. Beside hypoglycemic activity, these drugs also have antioxidants, bitter and other activity related to disturbance in carbohydrate metabolism. They are used in the form of decoctions, infusions, tablets, pills, and powder such as Qurse Dhayabitus, Qurse Tabasheer, Safoof Gilo, Qurse Marwareed, Qurse Gulnar, Dawaul Misk Talkh, Sharbate Afsanteen, Roghane Qusht, and Ma-Usshaeer and common marketed formulation is Dolabi tablets, Qurs Kushta baiza murgh, Qurs Kushta Zamarrud, Qurs Ziabetus, Safoof Ziabtes, Diab-eaze, etc. There is the tremendous scope of Unani single and compound formulations in the comprehensive management of diabetes particularly Type-2 diabetes; it can also be utilized as an adjuvant with the conventional drug due to its diverse and related beneficial pharmacological activity in diabetes.

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Anti-diabetic Activity on Ethanolic Extracts of Fruits of Terminalia chebula Retz. Alloxan Induced Diabetic Rats

Cited by 34 publications

References 0 publications

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Antioxidant activity of polyphenolic extract ofTerminalia chebulaRetzius fruits

Unani Formulations for Management of Diabetes: An Overview

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