Anti-diabetic and Anti-oxidative activities of Extracts from Crataegus pinnatifida

남상명,; 강일준,; 신미혜,

doi:10.17495/easdl.2015.4.25.2.270

Cited by 12 publications

(3 citation statements)

References 26 publications

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“…For instance, different ethanol concentrations (0-100%) were applied for C. pinnatifida and the yields were 19. 03, 33.16, 27.79, 21.88, and 21.71% at 100, 70, 50, 30 and 0% (water) concentration, however the highest TPC and DPPH • /ABTS •+ scavenging capacity was obtained in case of 50% (Kang, 2015). The technical and economic advantages of pressurized hot water (90 °C) extraction of C. monogyna compared to traditional percolation with ethanol and water (70:30, v/v) was shown by successful incorporation of natural batch variability into the physico-chemical process modelling concept (Sixt and Strube, 2018).…”

Section: Composition and Health Effects Of Phenolic Compoundsmentioning

confidence: 91%

“…Several beneficial events were determined: (1) lowering body and liver weight and liver/body weight ratio; (2) improving serum parameters and liver dysfunction; (3) decreasing hepatic lipid accumulation; (4) increasing circulating adiponectin levels and up-regulating the expression of adiponectin receptors (AdipoR2) in the liver; and (5) activating AMP-activated protein kinase (AMPK) and altering AMPK-mediated SREBP-1c, PPAR-α and their downstream targets . The inhibitory activities of C. pinnatifida extract isolated with 50% ethanol were more effective against formation of advanced glycation end products (AGEs) and α-glucosidase, while water extract better inhibited aldose reductase (Kang, 2015).…”

Section: Hypolipidemic Effectsmentioning

confidence: 99%

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Phytochemical composition and bioactivities of hawthorn ( Crataegus spp.): review of recent research advances

Venskutonis¹

2018

Journal of Food Bioactives

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Hawthorn (Crataegus spp.) is one of the most famous plants which has been used as natural medicine and nutraceutical. Its phytochemical composition, bioactive compounds and health benefits have been intensively studied and hawthorn preparations may be recognized as classical natural products for cardiovascular health. Polyphenolic compounds of different hawthorn anatomical parts as well as their extracts have been the focus of a majority of these studies, although various other classes of natural health promoting constituents have also been isolated, identified and characterized. Regardless, numerous published reports have particularly focused on the activity mechanisms which are very important for supporting various health benefits. This review summarizes the most recent studies on hawthorn, mainly published since 2015. Search of different databases indicates that approximately 200 publications, which are relevant to phytochemistry and health benefits of Crataegus spp., have appeared since then, most of them have not been included in the existing reviews.

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Section: Composition and Health Effects Of Phenolic Compoundsmentioning

confidence: 91%

Section: Hypolipidemic Effectsmentioning

confidence: 99%

Phytochemical composition and bioactivities of hawthorn ( Crataegus spp.): review of recent research advances

Venskutonis¹

2018

Journal of Food Bioactives

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“…2013년 기준 우리나라 사망원인 5위인 당뇨병은 인슐린이 제대로 작용하지 못해 체내 포도당의 대사가 정상적으로 작동 하지 않아 발생되는 대사장애를 말하며 심혈관계 질환, 망막 증, 족부병변 등의 합병증을 유발한다 [31]. 당뇨병성 합병증의 주요 원인 중 하나는 고혈당으로 인한 산화 스트레스 현상으 로, 이는 지속적인 고혈당 상태에서 포도당의 당화 과정 중 생성된 ROS로 인해 지질 과산화물 생성이 촉진되고 단백질의 당화 과정이 일어나 합병증이 발생하게 된다 [39].…”

Section: 서 론unclassified

Changes in Phenolic Composition, Antioxidant and Antidiabetic Properties of Jeju Citrus sudachi as Influenced by Maturity

이지은¹,

김지혜

김민영³

2015

Journal of Life Science

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The effects of fruit maturation on changes in the total phenolics, flavonoids, and carotenoids of methanolic extracts of Citrus sudachi, in addition to its antioxidant and antidiabetic activities, were determined. Generally, the concentration of these chemical constituents increased as C. sudachi reached maturity. C. sudachi contained high levels of total phenolics, flavonoids, and carotenoids at maturity, contributing 6339.5 mg of gallic acid equivalent per 100 g, 2364.2 mg of rutin equivalent per 100 g, and 678.7 mg/ml, respectively. The scavenging activities of 1,1-diphenyl-2-picryl hydrazyl (DPPH), hydrogen peroxide and nitric oxide radicals and the reducing power of mature fruits were significantly higher at all data points than those of immature fruits (p<0.05). In contrast, the ferrous ion chelating activity of mature and immature C. sudachi fruits was similar. The 50% effective concentrations (EC50) of mature fruits were 4.1±0.10 mg/ml for scavenging DPPH radicals, 3.1±0.02 mg/ml for scavenging hydrogen peroxide, 3.9±0.01 mg/ml for scavenging nitric oxide, and 3.8±0.02 mg/ml for chelating ferrous ion. The antidiabetic activity of C. sudachi was studied in vitro using the α-glucosidase inhibitory method. The inhibitory activity of mature C. sudachi fruits on α-glucosidase was higher than that of immature fruits. These results suggest that the content of bioactive compounds and the antioxidant and antidiabetic activities of C. sudachi change during maturation. These findings can be further extended to exploit them for their possible application for the preservation of food products, as well as their use as health supplements and nutraceuticals.

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Antioxidant abilities and physiological properties ofdried Haw extracts prepared using different drying methods

Nam¹,

Kwon²,

Chung³

et al. 2016

Korean Journal of Food Preservation

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This study was performed to determine the effects of drying methods (HD, hot air drying; FD, freeze-drying) on the antioxidant and physiological abilities of Haw (Crataegus pinnatifida Bunge). Powder color values of dried Haw, L and b, were higher for HD, while the chroma values were higher for FD. The total polyphenol, and flavonoid contents of HD Haw and FD Haw were found to be 9.29±0.50 mg GAE/mL and 15.48±0.38 mg GAE/mL, and 9.41±0.26 mg RHE/mL and 26.46±0.34 mg RHE/mL, respectively. DPPH radical scavenging abilities at 100 mg/mL concentration were higher for FD (64.90%) than HD (28.66%), as were the reducing power, ABTS radical scavenging ability, and nitrite scavenging ability. However, the HMG-COA reductase of HD (74.67%) was higher than that of FD (72.10%). The α-glucosidase inhibitory abilities of HD and FD at a concentration of 0.1 mg/mL were 24.69% and 97.38%, respectively. These results indicate that Haw is a potential functional material and that freeze-drying Haw is better than hot air drying. Key words：Haw (Crataegus pinnatifida Bunge), Drying method, Antioxidant ability

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Anti-diabetic and Anti-oxidative activities of Extracts from Crataegus pinnatifida

Cited by 12 publications

References 26 publications

Phytochemical composition and bioactivities of hawthorn ( Crataegus spp.): review of recent research advances

Phytochemical composition and bioactivities of hawthorn ( Crataegus spp.): review of recent research advances

Changes in Phenolic Composition, Antioxidant and Antidiabetic Properties of Jeju Citrus sudachi as Influenced by Maturity

Antioxidant abilities and physiological properties ofdried Haw extracts prepared using different drying methods

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