Anti-Diabetic and Antihyperlipidemic Activities of Alternanthera Sessilis in Experimentally Induced Type 2 Diabetes

Rayilla, Deepthi; Goverdhan, P

doi:10.9790/3008-1203064447

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…[62] According to the data from single and multi-dose studies and subacute investigation done for 15 days, ASG leaf extracts employed in both studies significantly (p<0.05) decreased the level of glucose in diabetic rats induced by streptozotocin. [61,62] Leaf extracts of concentrations 200 mg/kg and 400 mg/kg used for the oral glucose tolerance test significantly (p<0.05) decreased the level of glucose in blood which could be compared to the standard medication glibenclamide (10 mg/kg) utilized in both single and multi doses study. [61] For the 15 days study conducted, it revealed an inhibition rate of 50% and 51% for concentrations 100 mg/kg and 200 mg/kg respectively on the final day.…”

Section: Anti-hyperglycemia Activitiesmentioning

confidence: 99%

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Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar

Ragavan,

Chan,

Goh

et al. 2023

Pharmacogn. Res.

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The weed Alternanthera sessilis, having Green (ASG) and Red (ASR) cultivars, is a member of the Amaranthaceae. Both cultivars are known to possess high medicinal and nutraceutical values as they are widely utilized in traditional medicine. Populations from various Asian regions commonly consume this medicinal weed as part of diet and as therapeutic agent. In general, both cultivars have been employed for treating a broad range of human ailments including cardiovascular diseases, diabetes, hypertension, and inflammatory disorders such as asthma, bronchitis and hepatitis apart from its administration as a painkiller. Following its ethnomedicinal uses, an attempt was made to review and consolidate the phytochemical constituents of ASG and ASR discovered from previous studies that utilized advanced technologies, respective traditional application among different ethnicities of Asia and their established pharmacological properties. All the information in this study was acquired through a literature search of research databases, namely ScienceDirect, Scopus, PubMed and Google Scholar using keywords such as Alternanthera sessilis, Alternanthera sessilis red, dwarf copperleaf and sessile joyweed. The results of each study were reviewed to identify its relevance and the cultivar that was being investigated. All relevant studies were collected and its subsequent results were reported and discussed to provide insights into the health enhancing qualities of ASG and ASR. Inspection of phytoconstituents in ASG and ASR showed the presence of polyphenol, flavonoid, carotenoid, terpenes and alkaloid with polyphenol being the major chemical group found in both cultivars. It was also revealed that whilst ASR is traditionally consumed in China, Malaysia, Singapore, and Taiwan, indigenous usage of ASG is more common in nations such as Sri Lanka, India, and Indonesia. Both ASG and ASR showed potent anti-oxidant, anti-hyperglycemic, antimicrobial, antifungal and hepatoprotective effects while the anti-inflammatory, anti-cancer and analgesic properties were disclosed in ASG only. Further processing and commercialization of this remedial weed as a product benefiting the wellbeing of humans is recommended as Alternanthera sessilis has high potential to be utilized as a curative agent while being a vital ingredient that can be included in daily consumption.

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Section: Anti-hyperglycemia Activitiesmentioning

confidence: 99%

“…[61] For the 15 days study conducted, it revealed an inhibition rate of 50% and 51% for concentrations 100 mg/kg and 200 mg/kg respectively on the final day. [62] Part use…”

Section: Anti-hyperglycemia Activitiesmentioning

confidence: 99%

Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar

Ragavan,

Chan,

Goh

et al. 2023

Pharmacogn. Res.

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“…For this comparative study, a well-known traditional plant Alternanthera sessilis was used, as a vegetable in the Southern Region of India and also as a household remedy to get relief from many ailements [8][9][10][11] . The current study planned to explore cowʼs urine distillate as a solvent for the extraction and compare the "-amylase inhibitory activity of cowʼs urine extract with aqueous extract and analyze the bio-enhancing effect on bio-active principles of aqueous extract.…”

Section: Introductionmentioning

confidence: 99%

Exploring α-Amylase Inhibitory Activity of Cow’s Urine Extract of Alternanthera sessilis

Ramesh¹,

Mruthyunja²,

Kumar³

et al. 2022

Asian J. of Animal and Veterinary Advances

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Background and Objective: The current "-amylase and "-glucosidase inhibitors in clinical use such as acarbose, miglitol and voglibose are associated with undesirable side effects such as hypoglycemia, flatulence and diarrhoea due to the inhibitory effect of gastrointestinal digestion which limits their use in the treatment of diabetes when compared to the active principles of plant origin. This study explores the antidiabetic enhancing property of Alternanthera sessilis with cowʼs urine as compared to aqueous extract. Materials and Methods: The aqueous and cowʼs urine extract of Alternanthera sessilis was prepared by maceration and both extracts were subjected for in vitro "-amylase inhibitory activity. The obtained data were compared and analysed by MS office excel. Results: Cow urine has enhanced the time of hydrolysis of starch by "-amylase, which in turn exhibited an inhibitory effect on the "-amylase enzyme. Conclusion:From the research work it was revealed that cowʼs urine extract shows promising "-amylase inhibitory activity compared to aqueous extract. The cowʼs urine distillate as a solvent for the extraction and compare the "-amylase inhibitory activity of cowʼs urine extract with aqueous extract and analyze the bio-enhancing effect on bio-active principles of aqueous extract.

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Anti-Diabetic and Antihyperlipidemic Activities of Alternanthera Sessilis in Experimentally Induced Type 2 Diabetes

Cited by 2 publications

References 3 publications

Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar

Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar

Exploring α-Amylase Inhibitory Activity of Cow’s Urine Extract of Alternanthera sessilis

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