Anti-diabetic effect mediated by Ramulus mori polysaccharides

Xu, Lingyuan; Yang, Fenglian; Wang, Junli; Huang, Hao; Huang, Yan-Qiang

doi:10.1016/j.carbpol.2014.09.052

Cited by 42 publications

(13 citation statements)

References 32 publications

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“…Ethyl acetate-soluble extract of mulberry fruits also possesses strong α-glucoside inhibitory activity and radical-scavenging activities against 2,2-diphenyl-1-picrylhdrazyl (DPPH) and superoxide anion radicals [ 15 ]. A study by Xu, et al [ 68 ] reported that diabetic mice fed with mulberry fruit polysaccharides had a lower level of haemoglobin A1c (HbA1c) and a reduction in streptozotocin (STZ)-lesioned pancreatic cells. In addition, diabetic mice fed with mulberry fruit polysaccharides also had an increase in insulin level and B-cell lymphoma 2 (bcl-2) expression [ 68 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…A study by Xu, et al [ 68 ] reported that diabetic mice fed with mulberry fruit polysaccharides had a lower level of haemoglobin A1c (HbA1c) and a reduction in streptozotocin (STZ)-lesioned pancreatic cells. In addition, diabetic mice fed with mulberry fruit polysaccharides also had an increase in insulin level and B-cell lymphoma 2 (bcl-2) expression [ 68 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

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Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review

et al. 2018

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Mulberry (Morus alba L.) belongs to the Moraceae family and is widely planted in Asia. Mulberry fruits are generally consumed as fresh fruits, jams and juices. They contain considerable amounts of biologically active ingredients that might be associated with some potential pharmacological activities that are beneficial for health. Therefore, they have been traditionally used in traditional medicine. Studies have reported that the presence of bioactive components in mulberry fruits, including alkaloids and flavonoid, are associated with bioactivities such as antioxidant. One of the most important compounds in mulberry fruits is anthocyanins which are water-soluble bioactive ingredients of the polyphenol class. Studies have shown that mulberry fruits possess several potential pharmacological health benefits including anti-cholesterol, anti-obesity and hepatoprotective effects which might be associated with the presence of some of these bioactive compounds. However, human intervention studies on the pharmacological activities of mulberry fruits are limited. Therefore, future studies should explore the effect of mulberry fruit consumption on human health and elucidate the detailed compounds. This paper provides an overview of the pharmacological activities of mulberry fruits.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

Section: Pharmacological Propertiesmentioning

confidence: 99%

Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review

et al. 2018

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“…Previous studies have demonstrated that Morus alba exhibits comprehensive pharmacological effects that include, for example, hypoglycemic, immunomodulatory and antioxidant activities [19][20][21]. Our previous studies have found that RMP exerts hypoglycemic effect via regulating the intrapancreatic JNK/p38 pathway and blocking the IL-1/NF-κB pathway to protect against streptozotocin-induced apoptosis in pancreatic tissue and cytotoxicity in renal tissue [22][23][24]. Thus, we hypothesized that RMP might exert a beneficial effect on the development of DN.…”

Section: Mechanisms Of Protective Effect Of Ramulus Mori Polysaccharimentioning

confidence: 99%

Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

Gao

et al. 2015

Cell Physiol Biochem

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Background: Diabetic nephropathy (DN) is the most important complication of diabetes and the most common cause of end-stage renal disease (ESRD). Aims: A recent study established that the Ramulus mori polysaccharides (RMP) exert antioxidant effects on DN in rats. Methods: The diabetic rats which induced by high-fat diet and streptozotocin injection were orally administered RMP by doses of 250, 500 and 1000 mg/kg daily for 8 weeks. The effects of RMP on hyperglycemia and other biochemical changes were examined in the sera and kidney tissues. Additionally, the pathological and ultrastructural changes and expressions of nuclear-factor kappa B (NF-κB) and transforming growth factor-ß1 (TGF-ß1) were assessed. Results: The results revealed that the serum levels of blood glucose, total cholesterol (TC) and triglycerides (TG) were significantly decreased by RMP. Furthermore, the blood urea nitrogen (BUN), serum creatinine (SCr) and 24-hour urine protein levels in the RMP-medicated rats were lower than those in untreated diabetic rats. Moreover, treatment of the DN rats with RMP normalized all biochemical changes, including the malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in the serum and kidney tissues. In contrast, the protein expression levels of NF-κB and TGF-ß1, which were enhanced in the kidneys of DN rats, were reduced by RMP. Conclusion: These results suggest that RMP improving the renal function of diabeitc rats possibly via its ameliorating antioxidant activities.

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“…Mulberry branch, Ramulus mori , is a traditional Chinese medicine. Modern studies have shown that R. mori contains flavonoids, polyphenols, alkaloids, polysaccharides, and other active ingredients [4,5,6] that can have curative effects, including diabetes-alleviating and liver-protecting effects [7,8].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Polysaccharides from Ramulus mori, and Their Antioxidant, Anti-Inflammatory and Antibacterial Activities

Zhang

et al. 2019

Molecules

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The extraction of Ramulus mori polysaccharides (RMPs) was optimized using response surface methodology (RSM). The optimal process conditions, which gave the highest yield of RMPs (6.25%) were 80 °C, 50 min, and a solid–liquid ratio of 1:40 (g/mL), with the extraction performed twice. The RMPs contained seven monosaccharides, namely, mannose, rhamnose; glucuronic acid, glucose, xylose, galactose, and arabinose, in a 1.36:2.68:0.46:328.17:1.53:21.80:6.16 molar ratio. The glass transition and melting temperatures of RMPs were 83 and 473 °C, respectively. RMPs were α-polysaccharides and had surfaces that resembled a porous sponge, as observed by scanning electron microscopy. RMPs inhibited the proliferation of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and showed antioxidant activity (assessed by three different methods), although it was generally weaker than that of vitamin C. RMPs showed anti-inflammatory activity in a concentration-dependent manner. This study provides a basis for exploring the potential uses of RMPs.

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Anti-diabetic effect mediated by Ramulus mori polysaccharides

Cited by 42 publications

References 32 publications

Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review

Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review

Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

Preparation of Polysaccharides from Ramulus mori, and Their Antioxidant, Anti-Inflammatory and Antibacterial Activities

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