Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperone

Park, Sun-mi; Choi, Jung-Sook; Nam, Tae‐gyu; Ku, Jin‐Mo; Jeong, Kwiwan

doi:10.1016/j.ejphar.2016.03.023

Cited by 26 publications

(23 citation statements)

References 45 publications

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“…Consistent with these views, we found that palmitate induced insulin resistance in HUVECs in time- and concentration-dependent manners ( Figures 1A,B ). Moreover, palmitate-induced insulin resistance was accompanied with enhanced ER stress ( Figure 2A ), which has been suggested a major contributor to palmitate-induced insulin resistance through ER stress-activated JNK/IRS-1 pathway (Chan et al, 2013; Simon-Szabó et al, 2014; Tang et al, 2015; Park et al, 2016). Indeed, our results found that palmitate stimulated JNK/IRS-1 pathway ( Figures 4C,D ).…”

Section: Discussionmentioning

confidence: 98%

RETRACTED: Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

Qian

Zhang

et al. 2017

Front. Pharmacol.

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Dysfunction of proteasome and autophagy will result in disturbance of endoplasmic reticulum (ER) proteostasis, and thus lead to long-term and chronic ER stress and subsequent unfolded protein response (UPR), which is implicated in the occurrence and development of insulin resistance. Curcumin exerts beneficial metabolic effects in in vitro cells and in vivo animal models of diabetes and diabetic complications including cardiovascular diseases, due to its powerful anti-oxidative and anti-inflammatory properties. However, its impacts on insulin resistance of endothelial cells and its underlying mechanism(s) remain ill-defined. Herein, we tested the hypothesis that curcumin action in ER protein quality control was related to improvement of insulin resistance in human umbilical vein endothelial cells (HUVECs) cultured with saturated fatty acid palmitate. We found that palmitate treatment induced insulin resistance of HUVECs and activated both the ubiquitin-proteasome system (UPS) and autophagy. Palmitate-stimulated activation of the UPS and autophagy was attenuated by pharmacological inhibition of ER stress. In addition, curcumin supplementation mitigated palmitate-induced insulin resistance, inhibited the UPS, and activated autophagy. Furthermore, curcumin administration suppressed palmitate-induced protein aggregation and ER stress. Genetic inhibition of autophagy by silencing autophagy protein 5 (Atg5) completely restored total protein ubiquitination and protein aggregation in HUVECs treated with combined curcumin and palmitate. Atg5-knockdown also abolished the beneficial effects of curcumin on palmitate-induced ER stress, JNK/IRS-1 pathway as well as insulin signaling. Our results reveal that curcumin-activated autophagy could maintain proteostasis in ER leading to attenuation of ER stress and subsequent inhibition of JNK/IRS-1 pathway and improvement of insulin resistance.

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Section: Discussionmentioning

confidence: 98%

RETRACTED: Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

Qian

Zhang

et al. 2017

Front. Pharmacol.

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“…In HepG2 cells and in cultured adipocytes, the novel ER stress-reducing chemical chaperones hydroxynaphthoic acids (HNAs) reduced palmitate-induced phosphorylation of JNK, IKKβ, and IRS1 (S307) and restored insulin signaling cascade which involves insulin receptor β, IRS1, and Akt. Moreover, in vivo HNA treatment restored glucose tolerance and insulin sensitivity in the liver and the skeletal muscle [ 92 ]. Skeletal muscle is the primary site of insulin-mediated glucose uptake and is the main organ affected by insulin resistance and diabetes.…”

Section: Er Stress Induces Ir and Diabetesmentioning

confidence: 99%

Endoplasmic Reticulum Stress in Metabolic Disorders

Ghemrawi

Battaglia-Hsu

Arnold

2018

Cells

155

113

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Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these diseases has different physiological and clinical symptoms, they appear to share certain pathological traits such as intracellular stress and inflammation induced by metabolic disturbance stemmed from over nutrition frequently aggravated by a modern, sedentary life style. These modern ways of living inundate cells and organs with saturating levels of sugar and fat, leading to glycotoxicity and lipotoxicity that induce intracellular stress signaling ranging from oxidative to ER stress response to cope with the metabolic insults (Mukherjee, et al., 2015). In this review, we discuss the roles played by cellular stress and its responses in shaping metabolic disorders. We have summarized here current mechanistic insights explaining the pathogenesis of these disorders. These are followed by a discussion of the latest therapies targeting the stress response pathways.

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“…Accordingly, [HNA]has a positive effect on IL acute toxicity. The exact interaction with cells is unclear, but recent work revealed a positive influence of 3-hydroxy-2-naphthoate on cell activity [46], which indicates a generally lower toxicity of [HNA]compared to [C 6 SAc] -. Whereas no effect of alkyl chain length could be detected for growth of R. subcapitata, [P 66614 ][HNA] exhibited a slightly higher toxicity compared to the less hydrophobic cations [P 1888 ] + and [N 1888 ] + for T. obliquus.…”

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confidence: 99%

Heavy Metal Extraction under Environmentally Relevant Conditions Using 3-Hydroxy-2-Naphthoate- Based Ionic Liquids: Extraction Capabilities vs. Acute Algal Toxicity

Pirkwieser

López-López

Schagerl³

et al. 2020

Applied Sciences

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We investigated the applicability of three task-specific ionic liquids (ILs) as heavy metal extracting agents by contrasting extraction capabilities with algal toxicity. The compounds tested were trihexyltetradecylphosphonium-, methyltrioctylphosphonium- and methyltrioctylammonium 3-hydroxy-2-naphthoates. Experiments were performed to assess if these ILs can provide environmentally safe residual concentrations of the target metals after extraction. Both pure water and natural mineral water samples were spiked with 20 µg L−1 of Cu, Ag, Cd, Hg and Pb, respectively. Quantitative extraction (> 99%) of Hg and Ag was achieved. Cu and Hg were below the respective no-observed-effect-concentrations (NOECs) after extraction and Ag below 0.03 µg L−1. Acute toxicity assays were conducted using two freshwater green algae Raphidocelis subcapitata and Tetradesmus obliquus. Growth inhibition and maximum photochemical quantum yield of photosystem II after 72 h were assessed. ILs were less toxic than similar compounds, but still must be classified as acute toxicants for algae. An inhibiting effect on both growth and chlorophyll fluorescence was observed. The leaching of the ILs into the samples remains a limitation regarding their environmental-friendly applicability. Nonetheless, the extremely efficient removal of Cu, Ag and Hg under environmentally relevant conditions calls for further research, which should focus on the immobilization of the ILs.

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Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperone

Cited by 26 publications

References 45 publications

RETRACTED: Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

RETRACTED: Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

Endoplasmic Reticulum Stress in Metabolic Disorders

Heavy Metal Extraction under Environmentally Relevant Conditions Using 3-Hydroxy-2-Naphthoate- Based Ionic Liquids: Extraction Capabilities vs. Acute Algal Toxicity

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