Anti-Diabetic Effect of Anthocleista vogelii Ethanolic Root Extract in Alloxan-Induced Diabetic Rats

Abstract

This study was carried out to evaluate the potential anti-diabetic effect of Anthocleista vogelii ethanolic root extract in alloxan-induced diabetic rats. Albino rats of both sexes were randomly divided into five groups with five rats each. Group 1 (control; 10 mL kgG 1 distilled water), group 2-4 (100, 200 and 400 mg kgG 1 A. vogelii ethanolic root extract) and group 5 (5 mg kgG 1 glibenclamide). Diabetes was induced physiologically using 10 g kgG 1 glucose p.o. and chemically using 150 mg kgG 1 alloxan i.p. Fasting blood glucose levels of the diabetic rats were determined at intervals of 30, 60, 120 and 240 min in glucose loaded rats and on days 4, 7, 10 and 14 in alloxan-induced diabetic rats. After two weeks, the levels of serum cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, alanine aminotransferase, aspartate amino transferase and creatinine of all the groups were analyzed. The LD 50 of A. vogelii ethanolic root extract was $5000 mg kgG 1 (p.o.). The extract exerted a significant (p<0.05) reduction in Fasting blood glucose levels, serum cholesterol, triglyceride, low density lipoprotein, creatinine, alanine aminotransferase and aspartate aminotransferase levels and an increase in serum high density lipoprotein levels when compared to the control. The extract also elicited a significant decrease in body weight, food and water intake in diabetic treated rats. The results show that A. vogelii ethanolic root extract have anti-diabetic and anti-hyperlipideamic effect when administered for 14 days in alloxan-induced diabetic rats.

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes

“…However, our study showed that prolonged treatment with CF at doses above 100 mg/kg bw may lead to hypoglycemic condition. Findings of this study corroborate previous reports of the glucose lowering actions of A. vogelii extracts and fractions in diabetic rats (Osadebe et al, 2014;Sunday et al, 2016;Onyekere et al, 2017) and obese rats (Anyanwu et al, 2013).…”

Effect of Anthocleista vogelii leaves on free radicals: Antioxidant studies

“…Numerous research works have been done over the years to determine the biological activities of different solvent extracts of Anthocleista vogelii. These previous studies reported that Anthocleista vogelii exerted analgesic, antidiabetic [13,14] , anti-plasmodial [24] , antibacterial [25] and anti-fungal [26] effects. Earlier research works reported that some plants exert therapeutic properties which include analgesic [27] , anti-inflammatory [28] , anticancer [29,30] and antidiabetic [15,31] effect due to their antixodant activities.…”

“…Anthocleista vogelii belonging to the family Loganiaceae is a plant used in ethno-medicine for the treatment of various diseases which includes fever, syphilis, pile and stomach ache [11,12] . Previous studies reported that Anthocleista vogelii root exerted antidiabetic effect in albino rats that were induced with diabetes using streptozocin and alloxan [13,14] . Previous studies also reported the presence of phenolic content and antioxidant property of Anthocleista vogelii root [11] .…”

Renal Protective and Lipid Profile Modulatory Effects of Ethanol Extract of Anthocleista vogelii Stem Bark (EASB) in Renal Injury Rats Induced with Carbon-tetrachloride (CCl4)

“…The stem bark and leaf extracts of A. vogelii are used to treat malaria, diabetes, microbial infections, hypertension, rheumatism, fever, jaundice, and an ulcer (Alaribe et al, 2012;Anyanwu et al, 2013). The stem bark has also been reported to possess antidiabetic, antiulcerogenic, antiobesity, anti-infertility, antibiotic, and hepatoprotective properties (Oladimeji et al, 2014;Osadebe et al, 2014;Sunday et al, 2016;Chukwu et al, 2020). This study was therefore designed to investigate the renal protective and lipid profile modulatory effects of ethanol extract of A. vogelii stem bark (EASB) on rats induced renal injury with CCl4induction.…”