Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway

Liu, Yanlong; Dong, Man; Yang, Ziyu; Pan, Siyi

doi:10.1016/j.ijbiomac.2016.05.015

Cited by 106 publications

(51 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GSK‐3β functions as a negative feedback regulator of glycogen synthesis as it phosphorylates glycogen synthase, thus inactivating it (Wang et al., 2018). GSK‐3β activity is inhibited by phosphorylation at Ser9 induced by Akt, which plays a key role in alleviating insulin resistance by increasing glycogen synthesis (Liu, Dong, Yang, & Pan, 2016). GLUT2 is the primary type of glucose transporters in the liver, which promotes plasma glucose entrance to the cytoplasm at hyperglycemic states (Thorens, 2014).…”

Section: Resultsmentioning

confidence: 99%

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Xin

Zhang

et al. 2020

Journal of Food Science

View full text Add to dashboard Cite

We aimed to investigate) the effects of Aronia melanocarpa berry extract (AMBE) on hepatic insulin resistance and its mechanism at the molecular level in high-fat diet (HFD)-and streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats. The rats were supplemented with AMBE at doses of 100 and 400 mg/kg body weight (bw) daily for 8 weeks. AMBE significantly reduced blood glucose and serum insulin levels and the homeostatic model assessment for insulin resistance score; improved glucose tolerance; increased hepatic glycogen content; and regulated glucose metabolism enzyme activity, including glucokinase, pyruvate kinase, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase in the liver. AMBE also reduced lipid accumulation and oxidative stress along with inflammation in the hepatic tissue of T2DM rats and improved hepatic function. The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was activated by AMBE through the elevation of insulin receptor substrate-2, PI3K, Akt, and glycogen synthase kinase-3β phosphorylation and glucose transporter 2, which might contribute to the promotion of glycogen synthesis and improvement of hepatic insulin resistance. AMBE shows promise as an ingredient of functional foods for alleviating hepatic insulin resistance in T2DM.Keywords: Aronia melanocarpa berry, hepatic insulin resistance, PI3K/Akt signaling pathway, type 2 diabetes mellitus Practical Application: The extract from the berries of Aronia melanocarpa (Michx.) Elliott (AMBE), with its relatively high content of polyphenolic compounds, has been shown to exert hypoglycemic effects in animal models of diabetes. Our findings support the use of A. melanocarpa as a functional food additive for the alleviation of hepatic insulin resistance and the management of glucose homeostasis in T2DM.

show abstract

Section: Resultsmentioning

confidence: 99%

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Xin

Zhang

et al. 2020

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…One-week after the STZ injection, the fasting blood glucose (FBG) levels were measured in the rats using the glucometer (ACCU-CHEK, ROCHE). Rats with FBG above 11.1 mmol/L were used as diabetic rats ( 31 ). The animals were divided into four groups ( n = 10/group) as follows:…”

Section: Methodsmentioning

confidence: 99%

Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 Pathways

et al. 2018

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is the most common type of diabetes with more than hundreds of millions of patients worldwide. However, the medicines for treatment of T2DM are very limited. In China, Punica granatum L. flower (PGF) has been used as an anti-diabetic herb in the herbal medicine. The activity involves in improvement of insulin sensitivity. However, the underlying mechanism of action is elusive. The current study was designed to address this issue by investigating the effect of polyphenols extract of PGF in diabetic rats. A rat model was orally administrated with PGF polyphenols extract at doses of 50 and 100 mg/kg for 4 weeks. Insulin sensitivity was improved as indicated by oral glucose tolerance test (OGTT), insulin tolerance test (ITT) and homeostasis model assessment of insulin resistance (HOMA-IR). At the molecular level, insulin signaling activity was improved with an elevation in insulin-stimulated phosphorylation of insulin receptor substrate (IRS-1), Akt and GSK-3β. Endoplasmic reticulum (ER) stress signals including phosphorylation of inositol-requiring kinase1 (IRE1) and activation of X box binding protein (XBP-1) splicing were decreased by the PGF treatment. Expressions of IRE1α, XBPs, and CHOP were all decreased by PGF. Blood lipid profile, liver glycogen content and antioxidant status were improved by PGF in the rats. The observations suggest that PGF is able to lower glucose levels in T2DM rats by improving the insulin resistance. The mechanism is likely related to the activation of Akt-GSK3β signaling pathway and inhibition of ER stress.

show abstract

“…It was shown that the pectin existing in citrus peels contained a backbone chain composed of partly methyl‐esterified α ‐ d ‐galacturonic acids, which was substituted with various branch chains, such as rhamnogalacturonan I (RG‐ I) and rhamnogalacturonan II (RG‐II) . Recent studies have reported that some pectic fragments obtained by enzymatic degradation exhibited significant biological activities, such as prebiotic, antitumor metastasis and antidiabetic properties. Especially, the intestinal immunomodulating actions of pectic fragments have attracted more and more interest and the attention of researchers .…”

Section: Introductionmentioning

confidence: 99%

Characteristics and intestinal immunomodulating activities of water‐soluble pectic polysaccharides from Chenpi with different storage periods

Chang-cheng

et al. 2018

J Sci Food Agric

View full text Add to dashboard Cite

The present study demonstrates the differences in the pectic polysaccharides from Chenpi with different storage periods and also confirms that the pectic polysaccharides extracted from Chenpi stored over the long-term had more significant intestinal activities compared to that obtained from the fresh Chenpi. This phenomenon might partly explain why the Chenpi stored over the long-term has better healthcare effects. © 2018 Society of Chemical Industry.

show abstract

Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway

Cited by 106 publications

References 31 publications

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 Pathways

Characteristics and intestinal immunomodulating activities of water‐soluble pectic polysaccharides from Chenpi with different storage periods

Contact Info

Product

Resources

About