Anti-diabetic effect of Gymnema sylvestre an Alloxan-Induced Diabetic in Male Albino Wistar Rats

Beula, S. Janet; Suthakaran, R.; Viswaja, M.; Shankar, Ch.; Lakshmi, G. Sree

doi:10.52711/2231-5713.2023.00007

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…The leaves which are rich source of gymnemic acid may reduce hyperglycemia through the mechanisms like; increasing the enzymes activities that are actively involved in glucose utilization, increase in phosphorylation, decreasing the activity of enzymes involved in gluconeogenesis and sorbitol dehydrogenase. It also reduces or delays the intestinal absorption of glucose (Beula et al, 2023). Different civilizations around the world have employed herbal medicines for diabetes prevention and management since long time.…”

Section: Introductionmentioning

confidence: 99%

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Kashif,

Nasir,

Gulzaman

et al. 2023

Food Science & Nutrition

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The current study aimed to explore the anti‐diabetic effect of aqueous extracts of Gymnema sylvestre, Trigonella foenum‐graecum and mixture of both the plants in alloxan‐induced diabetic rabbits. A total of 30 rabbits were grouped into six equal groups as: normal control, diabetic control, diabetic treated with 300 mg/kg body weight (bw) G. sylvestre, diabetic treated with 300 mg/kg bw T. foenum‐graecum, diabetic treated with 300 mg/kg bw mixture of both the plants and diabetic treated with 500 mg/kg bw metformin for 4 weeks. Diabetes was induced to all the study group animals except normal control by intravenous administration of alloxan monohydrate (80 mg/kg bw). Blood glucose was measured by glucometer and other biochemical parameters were determined through various kit methods. Serum insulin was measured through ELISA kit method. Results showed that both the plants and metformin significantly (p < .05) decreased the fasting blood glucose. Hypoglycemic activity of aqueous extract of G. sylvestre and metformin was found slightly higher than aqueous extract of T. foenum‐graecum and the mixture of both the plants. However, a significant (p < .05) rise in insulin secretion was observed in studied plants extract treated rabbits. Serum urea, creatinine, and liver enzymes were found reduced significantly (p < .05) in treated rabbits whereas packed cell volume was also returned to normal in treated animals as compared to control group. The study concluded that G. sylvestre and T. foenum‐graecum extracts have comparable effects with metformin in normalizing the blood glucose level and have more pronounced effect than metformin in restoring the serum biochemical parameters to normal levels. Hence, these plants may be the good alternative medicine in managing the diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Kashif,

Nasir,

Gulzaman

et al. 2023

Food Science & Nutrition

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Improvement of Liver Function (AST and ALT) and Liver Tissue Catalase levels of Wistar rats induced with Alloxan by consuming Catfish oil extract

Ngesti Rahayu,

Rietta Kumala,

Taruna

et al. 2024

RJPT

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Background: Background: Type 2 Diabetes Mellitus (T2DM) is characterized by disrupted glucose metabolism, leading to hyperglycemia and insulin resistance, often associated with Secondary Hypertension (SH). Over 80% of SH patients exhibit glucose intolerance, with nearly 30% developing T2DM. There is a strong interaction between T2DM and NAFLD, representing a complex two-way relationship that influences the prognosis of the two diseases. Catfish oil extract boasts unsaturated fatty acids, including DHA, EPA, omega-3, vitamins A, B6, B12, D, and amino acids. Objective: This study aims to assess the impact of Pangasius sp. (catfish) oil extract administration on serum AST and ALT levels, as well as liver tissue MDA and CAT levels in alloxan-induced Wistar rats (Rattus norvegicus). Materials and Methods: Employing a pure experimental approach with a post-test-only control group design, three groups of 9 white male rats (Rattus norvegicus), along with one extra male rat, were included.K1 served as the negative control group (Wistar rats not subjected to any treatment). K2 acted as the positive control group (Wistar rats subjected to alloxan-induced diabetes at 150mg/kg BW). K3 represented the treatment group (diabetic model rats treated with catfish oil extract at 73mg/kg BW). Serum AST and ALT levels, as well as MDA and CAT levels in liver tissue, were measured at the study's conclusion. Results: The highest mean MDA levels in white rat liver tissue were K2 (3034.00 + 525.25 nmol/g), and the lowest was K3(2909.33+351.01nmol/g); the mean CAT liver tissue levels in rats the highest was K1 (1063.42+133.36U/mg), and the lowest was K3(894.78+132.93U/mg), the highest mean serum ALT levels of white rats was K2(230.34+63,58 U/L), and the lowest was K1(151.54+23.12 U/L) and the highest mean serum AST level in rats was K2(448.79+618.90U/L), and the lowest was K1(61.01+14.70U/L). Conclusion: Giving catfish oil supplementation can repair the damage in liver tissue, as evidenced by reductions in MDA levels and serum ALT and AST levels in diabetic model rats within the treatment group. Alloxan induction did not affect liver tissue CAT levels, as evidenced by a consistent decrease in liver tissue CAT levels in both the positive control and treatment groups.

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Amalgamation of Herbal extracts in the Experimentally Persuades Diabetic Nephropathy impediments in the Wistar Albino Rats

Kumar,

Sharma,

Vasudeva

2024

RJPT

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The present study is focused on the potential nephroprotective benefits of plant extracts when used alone or in combination therapy. The existing research study streptozotocin (60mg/kg) model was used to develop diabetes and its consequences, such as neuropathy and nephropathy. One of the key indicators of nephropathic consequences leading to changes in renal function.The obtained results demonstrated that the treatment of diabetic nephropathy was significantly improved by Calotropis gigantea (500mg/kg) both alone and in combination with Cucumis pubescens (500mg/kg). It might be concluded that in diabetes mellitus persuaded lipid dysregulation and oxidative stress in association with increase in blood glucose levels plays a key role in the commencement of nephropathy in diabetic rats. Along with modern allopathic medicine, treatment needs multidrug therapy; and besides the treatment, various complications are associated with these marketed medicines. The results of lipid profile abnormalities, oxidative stress, glycemic management, serum creatinine level, and blood urea regulation revealed that plants might potentially control and treat diabetic-induced diabetic nephropathy.Extracts of the Calotropisgiganteaand Cucumispubescens play a considerable and tremendous effect in the management of diabetic nephropathy.

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Anti-diabetic effect of Gymnema sylvestre an Alloxan-Induced Diabetic in Male Albino Wistar Rats

Cited by 3 publications

References 10 publications

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation

Improvement of Liver Function (AST and ALT) and Liver Tissue Catalase levels of Wistar rats induced with Alloxan by consuming Catfish oil extract

Amalgamation of Herbal extracts in the Experimentally Persuades Diabetic Nephropathy impediments in the Wistar Albino Rats

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