Anti diabetic effect of Momordica charantia (Bitter melone) on Alloxan induced diabetic rabbits

Vangoori, Yakaiah; Mishra, Saurabh; Ambudas, B; Ramesh, P.; Meghavani, G; Deepika, Keerti; Prathibha, A

doi:10.5958/j.2319-5886.2.2.014

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…The blood sugar levels are almost comes to the normal levels. The present results are agreed with Ying et al (2012); Yakaiah et al (2013) and Lin et al (2009) Yakaiah et al (2013 suggested that results of this study show that chronic oral administration of an extract of Momordica charantia fruit at an appropriate dosage may be good alternative anti diabetic agent in alloxan induced diabetics.…”

Section: Alloxan Induced Diabetes and Comparison With Bitter Melon Fruitsupporting

confidence: 93%

“…The present results are agreed with other results. Sharma et al (2009); Yakaiah et al (2013); Puri and Prabhu (2002) suggested that alloxan treatment increased the blood glucose level in treated birds compared to the control rabbits. Alloxan induced experimental diabetes is also associated with marked reduction of anti-oxidant enzyme superoxide dismutase activity in islets cells.…”

Section: Alloxan Induced Diabetes and Comparison With Controlmentioning

confidence: 99%

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Anti-diabetogenic impact of bitter melon (Momordica charantia) and mahogany (Swietenia macrophylla) on alloxan induced diabetic rabbit model

Begum

Aziz

Islam

et al. 2018

Asian Australas. J. Biosci. Biotechnol.

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The increasing prevalence of diabetes mellitus in recent years to the focus of public health interests in Bangladesh. Herbal medicinal plant such as mahogany and bitter melon can be used as alternative of synthetic drugs to avoid side effects and high cost. So the present study was undertaken to investigate the antidiabetogenic effect of bitter melon and mahogany on diabetic rabbits. Four months old rabbits were randomly assigned into five groups (T1, T2, T3, T4 and T5) with 4 rabbits. Group T1 was kept for negative (no alloxan) control, the rest of the group (T2, T3, T4 and T5) were injected with alloxan intramuscularly at a dose rate of 75mg /kg body weight. T2 was positive control group. Group T3, T4 and T5 was considered for bitter melon (150mg/kg b.w.), mahogany (50mg/kg b.w) and combined with previous dose respectively. Suspension of both fruit was tested for its efficacy in alloxan induced diabetic rabbit. Over the course of the trial, observations were recorded for induction of diabetics, blood glucose level, and body weight after 72 hours. Blood glucose level were increased significantly (p<0.05) in all treated groups compared to the control group and the highest induction was recorded in T2 group treated with alloxan. Body weight was decreased significantly (p<0.05) in all alloxan treated groups and lowest was recorded in group T2. There was significant decreased in blood glucose level in all bitter melon and mahogany treated group (T3, T4, T5) compared to the T2 group and lowest glucose level was recorded in T5 group. The present study reveals that combined treatment with bitter melon and mahogany decreases blood glucose level without affecting health of rabbits. The results of this study show that chronic oral administration of a suspension of bitter melon fruits and mahogany seeds in appropriate dosage may be good alternative as anti-diabetic agent. Asian Australas. J. Biosci. Biotechnol. 2018, 3 (2), 136-142

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Section: Alloxan Induced Diabetes and Comparison With Bitter Melon Fruitsupporting

confidence: 93%

Section: Alloxan Induced Diabetes and Comparison With Controlmentioning

confidence: 99%

Anti-diabetogenic impact of bitter melon (Momordica charantia) and mahogany (Swietenia macrophylla) on alloxan induced diabetic rabbit model

Begum

Aziz

Islam

et al. 2018

Asian Australas. J. Biosci. Biotechnol.

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“…Hal ini menunjukkan ekstrak buah pare memberikan efek penurunan kadar glukosa darah tergantung dosis. Ditunjukkan semakin tinggi dosis yang diberikan maka penurunan kadar glukosa darah semakin optimal (24).…”

Section: Hasil Dan Diskusiunclassified

THE PARE FRUIT ACTIVITY (Momordica charantia L.) AS HERBAL ANTI-HYPERGLYCEMIC FOR DIABETES MELLITUS CONDITIONS: LITERATURE REVIEW

Kusuma

Maesaroh

2020

JFI

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Diabetes Melitus (DM) merupakan gangguan metabolik yang ditandai dengan glukosa darah tinggi (hiperglikemia) dan gangguan metabolisme karbohidrat, lemak, dan protein akibat efek pada sekresi insulin dan sensitivitas insulin. Antidiabetes oral merupakan salah satu pilihan terapi untuk mengontrol glukosa darah meskipun penggunaannya berpotensi munculnya efek samping dan sangat merugikan terutama dalam penggunaan jangka panjang. Terapi komplementer berbahan herbal seperti buah pare (Momordica charantia L.) menjadi aspek potensial untuk menjadi terapi alternatif karena potensi efek samping yang lebih rendah dan biaya yang terjangkau. Studi ini menjelaskan mengetahui aktivitas buah pare (Momordica charantia L.) sebagai antihiperglikemia. Jenis penelitian ini adalah penelitan kajian literatur (literature review) yang dipaparkan secara deskriptif. Metode pencarian literatur menggunakan jurnal internasional dan nasional dengan sumber data sekunder yang dilakukan secara online dan diidentifikasi menggunakan database elektronik dari PubMed, Science Direct dan Google Scholar. Proses pengumpulan data menggunakan pendekatan PICO (Population, Intervention, Compare, Outcame). Hasil penelitian ini diketahui bahwa buah pare (Momordica charantia L.) mengandung senyawa antidiabetes diantaranya charantin dan polipeptida-p. Buah pare baik dalam bentuk ekstrak maupun non-extract dan dalam sediaan tunggal maupun kombinasi terbukti menurunkan kadar glukosa darah, meningkatkan sensitivitas dan kadar insulin, menormalkan kadar HbA1c, memperbaiki profil lipid serta mengurangi stres oksidatif. kesimpulan penelitian ini adalah buah pare sangat berpotensi sebagai herbal antihiperglikemia pada kondisi diabetes

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The safety and efficacy of Momordica charantia L. in animal models of type 2 diabetes mellitus: A systematic review and meta‐analysis

Peter

Nagendrappa

Kaligirwa

et al. 2020

Phytotherapy Research

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Type 2 diabetes mellitus is a chronic hyperglycemic condition due to progressively impaired glucose regulation. Momordica charantia L. could potentially improve hyperglycemia because its fruit extracts can alleviate insulin resistance, beta‐cell dysfunction, and increase serum insulin level. We evaluated the effect of M. charantia L. in comparison with a vehicle on glycemic control in animal models of type 2 diabetes mellitus. MEDLINE, Web of Science, Scopus, and CINAHL databases were searched without language restriction through April 2019. About 66 studies involving 1861 animals that examined the effect of M. charantia L. on type 2 diabetes mellitus were included. Fruits and seed extracts reduced fasting plasma glucose (FPG) and glycosylated hemoglobin A1c in comparison to vehicle control: (42 studies, 815 animals; SMD, −6.86 [95% CI; −7.95, −5.77], 3 studies, 59 animals; SMD; −7.76 [95% CI; −12.50, −3.01]) respectively. Also, the extracts have hepato‐renal protective effects at varying doses and duration of administration. Despite the observed significant glycemic control effect, poor methodological quality calls for future researches to focus on standardizing extract based on chemical markers and adopt measures to improve the quality of preclinical studies such as sample size calculation, randomization, and blinding.

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Anti diabetic effect of Momordica charantia (Bitter melone) on Alloxan induced diabetic rabbits

Cited by 3 publications

References 3 publications

Anti-diabetogenic impact of bitter melon (Momordica charantia) and mahogany (Swietenia macrophylla) on alloxan induced diabetic rabbit model

Anti-diabetogenic impact of bitter melon (Momordica charantia) and mahogany (Swietenia macrophylla) on alloxan induced diabetic rabbit model

THE PARE FRUIT ACTIVITY (Momordica charantia L.) AS HERBAL ANTI-HYPERGLYCEMIC FOR DIABETES MELLITUS CONDITIONS: LITERATURE REVIEW

The safety and efficacy of Momordica charantia L. in animal models of type 2 diabetes mellitus: A systematic review and meta‐analysis

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