2015
DOI: 10.4162/nrp.2015.9.1.22
|View full text |Cite
|
Sign up to set email alerts
|

Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice

Abstract: BACKGROUND/OBJECTIVESRecently, anthocyanins have been reported to have various biological activities. Furthermore, anthocyanin-rich purple corn extract (PCE) ameliorated insulin resistance and reduced diabetes-associated mesanginal fibrosis and inflammation, suggesting that it may have benefits for the prevention of diabetes and diabetes complications. In this study, we determined the anthocyanins and non-anthocyanin component of PCE by HPLC-ESI-MS and investigated its anti-diabetic activity and mechanisms usi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
34
0
1

Year Published

2015
2015
2022
2022

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 66 publications
(37 citation statements)
references
References 33 publications
2
34
0
1
Order By: Relevance
“…Purple corn is known as a good source of natural antioxidants (Pascual-Teresa et al, 2002) and its benefic effects on health are under active study (Finkel et al, 2013;Hosoda et al, 2012;Huang et al, 2015). It can also be considered as an interesting natural alternative for mitigating the oxidation of essential fatty acids during extrusion (Camire et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Purple corn is known as a good source of natural antioxidants (Pascual-Teresa et al, 2002) and its benefic effects on health are under active study (Finkel et al, 2013;Hosoda et al, 2012;Huang et al, 2015). It can also be considered as an interesting natural alternative for mitigating the oxidation of essential fatty acids during extrusion (Camire et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…At a later stage of T2DM, certain patients develop a progressive increase in the urinary albumin excretion rate, creatinine and BUN, which has been identified as diabetic nephropathy (39,40). The development of renal failure in diabetic nephropathy is due to oxidative stress or inefficient antioxidant systems (41).…”
Section: Discussionmentioning
confidence: 99%
“…It has also been reported that purple corn extract can have antidiabetic effects through the protection of the β cells of the pancreas, favoring the secretion of insulin and the activation of the AMPK pathway in diabetic mice. The extract also causes increased phosphorylation by AmpC-activated kinase protein (AmpK), decreases the activity of phosphoenolpyruvate carboxykinase (PEPCK), decreases the transcriptional activity of genes for glucose 6-phosphatase in the liver, and increases the expression of the glucose transporter 4 (GLUT4) in skeletal muscle [56].…”
Section: Corn and Metabolismmentioning
confidence: 99%