Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats

Pushparaj, Peter Natesan; Löw, H.; Manikandan, Jayapal; Tan, B. T. G.; Tan, C.H.

doi:10.1016/j.jep.2006.11.028

Cited by 254 publications

(181 citation statements)

References 19 publications

(23 reference statements)

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“…This abnormally high level of serum lipids is mainly due to the uninhibited action of lipolytic hormones on fat deposits (Pushparaj et al, 2007;Savage et al, 2007). Hypercholesterolemia and hypertriglyceridemia may also occur in STZ-treated rats (Pushparaj et al, 2007). In the present study, only triglycerides displayed a significant increase in STZ treated rats, whereas C. xanthocarpa decoct caused no significant variation in triglyceride levels.…”

Section: Biochemical Resultscontrasting

confidence: 38%

“…However, in both diabetic groups, blood triglycerides levels (Table II) had increased significantly (p < 0.05) in relation to the untreated control group by the end of the experimental period. The levels of serum lipids are usually high in diabetes mellitus, where such elevation represents a risk factor for coronary heart disease (Kesari et al, 2007;Pushparaj et al, 2007;Savage et al, 2007). This abnormally high level of serum lipids is mainly due to the uninhibited action of lipolytic hormones on fat deposits (Pushparaj et al, 2007;Savage et al, 2007).…”

Section: Biochemical Resultsmentioning

confidence: 99%

“…The levels of serum lipids are usually high in diabetes mellitus, where such elevation represents a risk factor for coronary heart disease (Kesari et al, 2007;Pushparaj et al, 2007;Savage et al, 2007). This abnormally high level of serum lipids is mainly due to the uninhibited action of lipolytic hormones on fat deposits (Pushparaj et al, 2007;Savage et al, 2007). Hypercholesterolemia and hypertriglyceridemia may also occur in STZ-treated rats (Pushparaj et al, 2007).…”

Section: Biochemical Resultsmentioning

confidence: 99%

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Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

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The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed. O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/ kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.Unitermos: Campomanesia xanthocarpa/farmacognosia. Diabete Melito/estudo experimental. Planta hipoglicemiante. Carboidratos/metabolismo. Lipídeos/metabolismo.

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Section: Biochemical Resultscontrasting

confidence: 38%

Section: Biochemical Resultsmentioning

confidence: 99%

Section: Biochemical Resultsmentioning

confidence: 99%

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Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

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“…Significant increases in catalytic concentration of glutathione S-transferases in the liver of diabetic NOD mice [81]. Its dietary inulin-type fructans promote secretion of endogenous gastrointestinal peptides involved in appetite regulation [82] and via reduction in the hepatic Glc-6-pase activity thus decreasing hepatic glucose production, with no possibility of inducing insulin secretion from pancreatic beta-cells [83], also through adipogenesis inhibition and PPARgamma upregulation, inhibition of protein tyrosine phosphatase 1B and regulation of insulin signalling markers [77,84]. α-Glucosidase inhibition [85].…”

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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“…Roasted roots that are rich in inulin have been used as a coffee substitute for centuries, root extracts have also been used as a remedy for malaria [1] , antibacterial activity [2] , and cancer of the breast and face [3,4] , and against Ehrlich ascites carcinoma [5] . Leaves are very common in salad as they promote appetite, digestion [6] , and possess strong antioxidant properties [2] . Their juice is known in folk medicine as a remedy to treat uterus tumors along with many other tumor types.…”

Section: Introductionmentioning

confidence: 99%

Sensitization of Photohemolysis by a New Extraction from Flowers and Aerial Parts of Cichorium Pumilum Jacq: Effects of Inulin and Hydrogen Peroxide

Al-Akhras¹,

Amin²,

Mohammad³

et al. 2007

American J. of Pharmacology and Toxicology

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Addition of inulin and hydrogen peroxide to new photosensitizers extracted from the flowers and aerial parts of the chicory (Cichorium Pumilum Jacq) have been investigated. Some of the isolated photosensitizers remain unidentified compounds. Chicory extracts are found to be dependent on light and temperature. Higher photohemolysis rate was noticed under the influence of light as compared to temperature. The effect of H 2 O 2 on phototoxicity reported in this study showed a rapid reduction in the fractional hemolysis percentage at higher temperature. Compared to erythrocytes with higher concentrations and under the influence of solar irradiance 505.29±24.96w/m 2 , erythrocytes with lower concentrations of inulin and H 2 O 2 were ruptured faster. Samples with 0.95mg/ml of herb extract and different concentrations of inulin (1mg/ml -2mg/ml) shows no temperature effects at 40 C in the absent of sunlight.

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Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats

Cited by 254 publications

References 19 publications

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Sensitization of Photohemolysis by a New Extraction from Flowers and Aerial Parts of Cichorium Pumilum Jacq: Effects of Inulin and Hydrogen Peroxide

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