2015
DOI: 10.1016/j.phytochem.2015.02.017
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Anti-diabetic effects of Ganoderma lucidum

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Cited by 150 publications
(99 citation statements)
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“…Although higher concentrations of Li 2 CO 3 , 0.75 and 1.0 mM, significantly decreased the biomass, the Li accumulation exceeded 40 and 60 mg kg −1 dry matter, respectively. The commercial application of Li-enriched G. lucidum may be additionally supported for the medicinal properties of this species, which have long been acknowledged [29,[36][37][38]. Considering that the market for G. lucidum is already worth over 2.5 billion US dollars [39], the commercial introduction of its Li-enriched form should not be troublesome.…”
Section: Discussionmentioning
confidence: 99%
“…Although higher concentrations of Li 2 CO 3 , 0.75 and 1.0 mM, significantly decreased the biomass, the Li accumulation exceeded 40 and 60 mg kg −1 dry matter, respectively. The commercial application of Li-enriched G. lucidum may be additionally supported for the medicinal properties of this species, which have long been acknowledged [29,[36][37][38]. Considering that the market for G. lucidum is already worth over 2.5 billion US dollars [39], the commercial introduction of its Li-enriched form should not be troublesome.…”
Section: Discussionmentioning
confidence: 99%
“…Since then, fungi have been used as traditional Chinese medicines for the prevention or treatment of various chronic diseases [1, 2]. As research on the chemical constituents of these medicinal or edible fungi has increased, there is pre-clinical evidence for G. lucidum in an array of settings including cancer treatment [36], diabetic control [79], hepato-protection [10–13], antiviral treatment [14], and immune-modulation [15, 16]. …”
Section: Introductionmentioning
confidence: 99%
“…The 30-day treatment with the hydroethanolic extract (containing beta-glucan, proteins, and phenols) of G. lucidum fruiting bodies exhibited hypoglycaemic effects in STZ-induced diabetic rats (Bach et al 2018). In addition, many identified bioactive constituents in G. lucidum fruiting bodies, such as polysaccharides, proteoglycans, proteins, ganoderic acids, and triterpenoids, have been shown to exhibit hypoglycaemic activities (Ma et al 2015). Polysacc harides inhibited hyperglycaemia by regulating the expression of several key enzymes in the glucose metabolism pathway, such as hepatic glucokinase, phosphofructokinase, G6PD, hepatic glycogen phosphorylase, fructose-1,6-bisphosphatase, phosphoenolpyruvate carboxykinase, and G6Pase (Xiao et al 2012).…”
Section: Discussionmentioning
confidence: 99%