Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice

Sharma, Bhavna; Salunke, Rajani; Balomajumder, Chandrajit; Daniel, Supriya; Roy, Partha

doi:10.1016/j.jep.2009.10.013

Cited by 133 publications

(76 citation statements)

References 32 publications

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“…These excessive amino acids are then converted to ketonic bodies (alpha-ketoglutaric and pyruvate), for which the enzymes GOT and GPT are needed, leading to increased enzyme activity [35]. However, the aqueous extracts of Phragmites australis treated rats showed a significant reduction in the levels of these enzymes when compared to the diabetic group, thus an indication of the protective effects of the aqueous extracts over alloxan-induced liver damage which is in agreement with the other investigation [36]. Pancreatic Islets are especially vulnerable to oxidative stress mediated injuries because the antioxidant defence system of the pancreas is considerably weaker than those of other tissues [37].…”

Section: Discussionsupporting

confidence: 84%

Effect of Extracts Aqueous of Phragmites Australis on Carbohydrate Metabolism, Some Enzyme Activities and Pancreatic Islet Tissue in Alloxan-Induced Diabetic Rats

Derouiche

Manel

Hamida

2017

Int J Pharm Pharm Sci

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Objective: The present study was aimed to investigate the effects of the aqueous extract of rhizome of phragmites australis on carbohydrate metabolism, some enzyme activities and pancreatic tissue in alloxan induced diabetic rats. Methods:Wistar rats were divided into three groups (n=6) as control, diabetic group and test groups (Diabetic+AEPA). Diabetes in rats was induced by alloxane using a single peritoneal injection of 150 mg/kg dose. Aqueous extract of Phragmites australis was supplemented (200 mg/kg b. w) orally for three weeks. The aqueous extract of Phragmites australis was prepared and phytochemical were analyzed by using standard methods. Blood glucose level, pancreas histology and various biochemical parameters were assessed. Results:The results of the phytochemical analysis of aqueous extract of Phragmites australis (AEPA) revealed the presence of tannin, terpenoids, glycosides and flavonoids. Compared with the control, a significant decrease in the body weight gain (p<0.01) and increase in food intake (p<0.001) were noticed in the diabetic group. The biochemical evaluation showed significantly higher values for glucose (p<0.001), lipid profile (p<0.05), transaminases (p<0.05), amylase and alkaline phosphatase (p<0.001) activities in diabetic group compared with the control. Histology of the pancreas showed congestion of vessels and focal area of necrosis in diabetic untreated rats. However, treatment with aqueous extract of Phragmites australis significantly normalized blood glucose, serum biochemical profile and pancreas histomorphology. Conclusion:It is suggested that aqueous extract of Phragmites australis exhibits a benefic effect in rat to a great extent in attenuating and restoring the damage sustained by diabetes.

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Section: Discussionsupporting

confidence: 84%

Effect of Extracts Aqueous of Phragmites Australis on Carbohydrate Metabolism, Some Enzyme Activities and Pancreatic Islet Tissue in Alloxan-Induced Diabetic Rats

Derouiche

Manel

Hamida

2017

Int J Pharm Pharm Sci

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“…It reflects two possibilities: either the fraction has insulin-like effect or it directly stimulates the enzymes involved in glucose metabolism (Sharma et al, 2007). Hypertriglyceridemia and hypercholestremia are two major problems in patients with diabetes mellitus and are responsible for vascular complications (Sharma et al, 2010). In our study, improvement in lipid profile after administration of PPABTF shows the hypolipidemic nature of the fraction, which affects the cholesterol metabolism (Babu et al, 2007;Fan et al, 2006).…”

Section: Discussionmentioning

confidence: 63%

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Agrawal¹,

Sethiya²,

Mishra³

2013

Pharmaceutical Biology

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Context: The roots of Aerva lanata Linn. (Amaranthaceae) (AL) are employed traditionally as an antihyperglycaemic in the Ayurvedic system of medicine. Objective: The present investigation is focus for identification and isolation of the bioactive compound from methanol roots extract of AL against streptozocin-nicotinamide induced elevated serum glucose level in rats. Materials and methods: The methanol extract of the roots was fractionated using different solvents. The partially purified alkaloid basified toluene fraction (PPABTF) showed the presence of alkaloids. The fraction (10 and 20 mg/kg) was tested for oral glucose tolerance test (OGTT) and in non-insulin-dependent diabetes mellitus (NIDDM)-induced elevated serum glucose level in rats. The fraction was also subjected to high performance thin layer chromatography (HPTLC) for the determination of content of individual alkaloids. Results: Single oral administration of PPABTF (10 and 20 mg/kg) after 20 h caused a significant (p50.01) reduction in the serum glucose level (mg/dl). On other hand, PPABTF normalised plasma glucose levels after 2 weeks of repeated oral administration in diabetic rats (p50.01). HPTLC analysis on PPABTF showed the presence of three known alkaloids. The fraction was further subjected to column chromatography and the compounds identified by ultraviolet, infrared, mass spectroscopy and nuclear magnetic resonance, as canthin-6-one derivatives. Conclusion and discussion: The PPABTF in the dose of 20 mg/kg showed significant effects on streptozotocin-nicotinamide induced type-II NIDDM in rats. The activity may be due to the presence of alkaloids like canthin-6-one derivatives.

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“…It phosphorylates itself with the aid of ATP, undergoes a conformational change, and activates via a G-proteins, which liberates several second messenger further activates protein P-kinases which open a Ca 2+ influx gives insulin like effect [26] . Another possible mechanism may be due to alkaloids causing inhibition of mitochondrial function that increases the AMP/ATP ratio, which could explain the activation pathway in the treatment of diabetes [27] . The third most important probable mechanism of action may be by potentiating the insulin effects of plasma by increasing either the pancreatic secretion of insulin from the existing beta cells or by its release from the bound form.…”

Section: Discussionmentioning

confidence: 99%

Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta–cells of alloxan induced diabetic rats

Monday

Uzoma

2013

Asian Pacific Journal of Tropical Biomedicine

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Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice

Cited by 133 publications

References 32 publications

Effect of Extracts Aqueous of Phragmites Australis on Carbohydrate Metabolism, Some Enzyme Activities and Pancreatic Islet Tissue in Alloxan-Induced Diabetic Rats

Effect of Extracts Aqueous of Phragmites Australis on Carbohydrate Metabolism, Some Enzyme Activities and Pancreatic Islet Tissue in Alloxan-Induced Diabetic Rats

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta–cells of alloxan induced diabetic rats

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