Anti-diabetic potential of Chamaerops humilis L. aerial parts: Phenolic compounds with α-amylase and α-glucosidase inhibitory activates in-vitro, in-vivo and in-silico studies

Nabil, Marian; Kassem, Iman A.A.; Ghaly, Neveen S.; El-Manawaty, May A.; El-Sayed, Ahmed F.; Melek, Farouk R.; Raslan, Mona A.

doi:10.1016/j.molstruc.2024.138550

Journal of Molecular Structure

2024

DOI: 10.1016/j.molstruc.2024.138550

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Anti-diabetic potential of Chamaerops humilis L. aerial parts: Phenolic compounds with α-amylase and α-glucosidase inhibitory activates in-vitro, in-vivo and in-silico studies

Marian Nabil,

Iman A.A. Kassem,

Neveen S. Ghaly

et al.

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2024

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Enrichment, Antioxidant and Enzyme Inhibition Activities of Flavonoids from Artemisia Selengensis Turcz.

Wang,

Shi

et al. 2024

Chemistry & Biodiversity

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Macroporous resin was used to enrich flavonoids in the ethyl acetate extract of Artemisia Selengensis Turcz. Based on a single factor experiment, the enrichment process was optimized using the response surface method. The optimal parameters of the enrichment process were a sample concentration of 0.3 mg/mL, a loading rate of 1 mL/min, an elution flow rate of 2 mL/min, and a total flavonoid content of 155.38 ± 0.97 mg/g. The flavonoids enriched by AB‐8 macroporous resin demonstrated significant scavenging activities against DPPH, ABTS+, and hydroxyl free radicals, and also exhibited certain inhibitory effects on α‐amylase and α‐glucosidase. Among them, the scavenging ability of the flavonoids enriched by AB‐8 macroporous resin on hydroxyl free radical (IC50 = 30.31 ± 1.92 μg/mL) was the closest to Vc, and the inhibitory effect on α‐glucosidase (IC50 = 16.19 ± 1.35 μg/mL) was the best. These findings confirmed the potential of Artemisia Selengensis Turcz. is a natural antioxidant and hypoglycemic drug.

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Enrichment, Antioxidant and Enzyme Inhibition Activities of Flavonoids from Artemisia Selengensis Turcz.

Wang,

Shi

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

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Anti-diabetic potential of Chamaerops humilis L. aerial parts: Phenolic compounds with α-amylase and α-glucosidase inhibitory activates in-vitro, in-vivo and in-silico studies

Cited by 1 publication

References 60 publications

Enrichment, Antioxidant and Enzyme Inhibition Activities of Flavonoids from Artemisia Selengensis Turcz.

Enrichment, Antioxidant and Enzyme Inhibition Activities of Flavonoids from Artemisia Selengensis Turcz.

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