Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae)

Raman, Amala; Lau, Clara Bik‐San

doi:10.1016/s0944-7113(96)80080-8

Cited by 326 publications

(214 citation statements)

References 73 publications

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“…Analysis of the structure of vicine reveals a pyrimidine nucleus. Pyrimidine nucleoside is found to induce hypoglycemia in non-diabetic fasting rats by intraperitoneal administration (Raman and Lau, 1996). -5.69 -17.36 Mulling over the structure-activity of the pyrimidine nucleus, the structure of vicine was modified by replacing the -OH and -NH 2 groups with different functional groups (Fig.…”

Section: Resultsmentioning

confidence: 99%

Maestro 9.4 as a Tool in the Structure Based Screening of Glycoalkaloids and Related Compounds, Targeting Aldose Reductase

Firdhouse¹,

Lalitha²

2015

Trends in Bioinformatics

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Diabetes mellitus is one of the alarming common diseases of this century. In India, according to the statistics of the International Diabetes Federation, 87 million of people are affected by Diabetes mellitus and this number is expected to cross 100 million by 2030. This has created a thrust for the development of new medicines. Recently, ban of pioglitazone, an oral anti-diabetic drug by Drugs Technical Advisory Board (DTAB) on account of its side effects, portrays the need for developing new drugs with less or no side effects. Cheminformatics tools assist in screening several millions of compounds and providing lead compounds in drug designing. This paper focuses on screening of lead compounds in arriving at newer drugs for Diabetes mellitus. Aldose reductase a cytosolic enzyme is the receptor to which selected lead compounds are docked. Glycoalkaloids (present in bitter melon) and related compounds were docked onto aldose reductase and based on the GLIDE score, structural modifications were carried out to arrive at the highest GLIDE score. A commercially available molecule recommended for Type 2 Diabetes mellitus was also taken for reference. Glycoalkaloids were found to possess high GLIDE score compared to standard. In order to analyze the competence of the Schrodinger software a comparison was made with an internet freeware Hex 6.3 version. The flexible receptor docking of Schrodinger was found to be more advantageous than the Hex 6.3. Key words: Diabetes mellitus, aldose reductase, glycoalkaloids, GLIDE score INTRODUCTIONHuman life span is on an increase and aging is also postponed in recent days. Innovative medicines play a profound role along with nutrition, sanitation and other public health measures in increasing the average life span of man. Still there are many of the most common human diseases that are not effectively treated by existing therapies. With the improved technologies, researchers are focusing on genes and proteins responsible for genetic disorders and common polygenic diseases such as diabetes, heart disease etc. The increased pressure from the cost of clinical investigations and insufficient sources of financial support in research promotes cheminformatics (Hughes et al., 2011;Van de Waterbeemd and Gifford, 2003;Guttula et al., 2011;Umamaheswari et al., 2012).In order to facilitate the speed and cost involved in the drug discovery, a number of computational methods are used. The successfulness of the methods depend on number of factors like ligand structure, target receptor structure etc. In molecular modeling, the crystal structure,

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Section: Resultsmentioning

confidence: 99%

Maestro 9.4 as a Tool in the Structure Based Screening of Glycoalkaloids and Related Compounds, Targeting Aldose Reductase

Firdhouse¹,

Lalitha²

2015

Trends in Bioinformatics

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“…For example, Momordica charantia L. is locally used to treat diabetic and its biological activity for Anti-diabetic (Raman and Lau, 1996). Tiliacora triandra (Colebr.)…”

Section: Biological Activitiesmentioning

confidence: 99%

A survey of medicinal plants around upper Songkhla lake, Thailand

Neamsuvan¹,

Sengnon²,

Seemaphrik³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Upper Songkhla Lake, a single lagoon of Thailand, is surrounded by sandy, mangrove, and swamp forests. Many plants growing in these areas have medicinal properties, however they have never been investigated. The aim of this study was to explore medicinal plants from upper Songkhla Lake, Songkhla and Phatthalung provinces. Materials and Methods: Semi-structured interviews were conducted with seven key informants to get information regarding the local names, parts and utilization, method of preparation, route of administration and properties of plants. Voucher specimens were prepared, identified and deposited. Results: In total, 95 species belonging to 82 genera in 46 families were found. Among them 26 groups of ailments could be classified, and most of the herbal plants were used for antipyretic (24.30%). Conclusion: It was found that the natural sources of medicinal plants were damaged by many human activities. Therefore, this compilation of medicinal plants will be the data evidence for further conservation of the plants.

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“…A number of medicinal or culinary herbs have been reported to yield hypoglycaemic effects on diabetic conditions. These include bitter melon, Momordica charantia (Srivastava et al, 1993;Raman and Lau, 1996); onions and garlic, Allium cepa, A. sativum (Koch and Lawson, 1996) and holy basil, Ocimum sanctum (Rai et al, 1997). Some other common botanicals demonstrating in vivo hypoglycaemic activities in animals include juniper berries (Sanchez de Medina et al, 1994) and alfalfa (Gray and Flatt, 1997).…”

Section: Introductionmentioning

confidence: 99%

Haematology and serum biochemistry of alloxan-induced diabetic rats administered with extracts of Phragmanthera incana (Schum.) Balle

Ogunmefun¹,

Fasola²,

Saba³

et al. 2017

Afr. J. Pharm. Pharmacol.

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This study evaluated the toxic changes that may accompany treatment of diabetes with Phragmanthera incana, a mistletoe species growing on two plant hosts [Cola nitida (Kolanut; PICN) and Theobroma cacao (Cocoa; PITC)]. The toxic potential of this treatment regimen was evaluated using the effect of the extracts PICN and PITC on the haematology and serum chemistry of the diabetic rats. Alloxan-induced diabetic rats were treated with the extracts at doses of 200, 400 or 800 mg/kg or glibenclamide for 14 days. Blood samples were collected on day 15 for haematology and serum biochemistry. Haematological parameters analyzed were packed cell volume, haemoglobin, red blood cells, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), white blood cell count, platelet count, lymphocytes, neutrophil, monocytes and eosinophil. Serum biochemical parameters analyzed were total protein, albumin, globulin, albuminglobulin ratio, aspartate transaminase, alanine transaminase, alanine phosphatase, blood urea nitrogen, creatinine, cholesterol, bilirubin and glucose. The results showed that P. incana extracts, regardless of the host plant decreased blood glucose and cholesterol levels. Although it depressed packed cell volume (PCV), it also alleviated other complications of diabetes such as liver and kidney injury, and may possess hepatoprotective effect.

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Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae)

Cited by 326 publications

References 73 publications

Maestro 9.4 as a Tool in the Structure Based Screening of Glycoalkaloids and Related Compounds, Targeting Aldose Reductase

Maestro 9.4 as a Tool in the Structure Based Screening of Glycoalkaloids and Related Compounds, Targeting Aldose Reductase

A survey of medicinal plants around upper Songkhla lake, Thailand

Haematology and serum biochemistry of alloxan-induced diabetic rats administered with extracts of Phragmanthera incana (Schum.) Balle

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