Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait.

Martineau, Louis C.; Couture, Audrey; Spoor, Danielle; Benhaddou-Andaloussi, Ali; Harris, Cory S.; Meddah, Bouchra; Leduc, Charles; Burt, A; Vuong, Tri; Le, Phuong Mai; Prentki, Marc; Bennett, Steffany A. L.; Arnason, John T.; Haddad, Pierre S.

doi:10.1016/j.phymed.2006.08.005

Cited by 237 publications

(174 citation statements)

References 45 publications

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“…In an experiment with diabetic rats, resveratrol increased the expression of GLUT-4 in muscles [59]. Likewise other phytochemicals such as anthocyanins and anthocyanidins have demonstrated an antiglycation activity through upregulation of PPAR gamma expression or other genes engaging in glucose or lipid metabolism [102]. In an animal study, puerarin isolated from P. lobata decreased CMLinduced inflammation by induction of the HO-1(heme oxygenase-1) enzyme expression.…”

Section: Regulation Of Gene Expressionmentioning

confidence: 98%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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Section: Regulation Of Gene Expressionmentioning

confidence: 98%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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“…Considering that, in a separate pharmacological study, each extract (leaf, stem, root and fruit) elicited a range of in vitro anti-diabetic activities (Martineau et al, 2006), it is interesting that all the identified classes of phenolic compounds, chlorogenic acid, quercetin derivatives, procyanidins and anthocyanins, have demonstrated anti-diabetic potential in vitro and in vivo (Hemmerle et al, 1997;Rodriguez de Sotillo and Hadley, 2002;Kim et al, 2003;Tsuda et al, 2003;Pinent et al, 2004;Ajay et al, 2005;Coskun et al, 2005;Dias et al, 2005;Jayaprakasam et al, 2006 …”

Section: Figurementioning

confidence: 99%

“…The traditional medicinal uses of the plant, however, include the leaves, stems and roots in addition to the fruits to treat different diabetic symptoms. Moreover, in a recent in vitro study, extracts of V. angustifolium leaf, stem, root and berry each elicited a different spectrum of anti-diabetic activities (Martineau et al, 2006). Few, if any, studies have investigated or compared the chemistry of these sources.…”

Section: Introductionmentioning

confidence: 99%

A single HPLC‐PAD‐APCI/MS method for the quantitative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium

Harris

Burt

Saleem

et al. 2007

Phytochemical Analysis

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A method was developed for the analysis of Vaccinium angustifolium Ait. (Lowbush blueberry), which is a widely used natural health product, particularly for the treatment of diabetic symptoms. While the anthocyanin content of the fruit has been well characterized, the chemistry of the vegetative parts used in supportive therapy for diabetes has been largely ignored. Using a metabolomics-based approach for compound identification with an emphasis on phenolic metabolites, a single HPLC-PAD-APCI/ MS method was developed for the separation and quantitation of the major metabolites found in the 95% ethanol extracts of leaf, stem, root and fruit. The leaf extract contained high concentrations of chlorogenic acid (~100 µg/mg extract) and a variety of quercetin glycosides that were also detected in the fruit and stem extracts. Flavan-3-ol monomers (+)-catechin and (−)-epicatechin were found in all plant parts but their procyanidin dimers were exclusively identified in the stem and root. The accuracy and precision of the presented method were corroborated by low intra-and inter-day variations in quantitative results in all plant part extracts. Further validation of the extraction and analytical protocols focused on identified compounds with reputed anti-diabetic activity, revealing recoveries greater than 80% and detection limits of 0.12-2.73 µg/mL.

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“…[15][16][17] Biotransformation of blueberry juice with a novel strain of bacteria isolated from the blueberry flora and named Serratia vaccinii increases its phenolic content and antioxidant activity 18 and modifies its biological activity. 14 Biotransformed blueberry juice (BJ) increased AMP-activated protein kinase phosphorylation and glucose uptake in muscle cells and adipocytes, but inhibited adipogenesis. 19 As BJ showed potential antiobesity and antidiabetic activities in vitro, the aim of this study was to assess the antiobesity and antidiabetic potential of BJ in vivo.…”

Section: Introductionmentioning

confidence: 99%

Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy mice

et al. 2009

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Aim: Biotransformation of blueberry juice by the Serratia vaccinii bacterium gave rise to adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and glucose uptake in muscle cells and adipocytes, but inhibited adipogenesis. This study investigated the antiobesity and antidiabetic potential of biotransformed blueberry juice (BJ) in KKA y mice, rodent model of leptin resistance. Methods: BJ was incorporated in drinking water of KKA y mice. Parameters of body weight, food intake, plasma glucose, insulin, leptin, and adiponectin were measured. Before and after therapy, animals were subjected to an oral glucose tolerance test. At the end of treatment, liver, muscle, kidney, epididymal fat pad, abdominal fat pad, and dorsal fat pad were collected and weighed. Results: Incorporating BJ in drinking water protected young KKA y mice from hyperphagia and significantly reduced their weight gain. Moreover, BJ protected young KKA y mice against the development of glucose intolerance and diabetes mellitus. Chronic BJ administration in obese and diabetic KKA y mice reduced food intake and body weight. This effect could not fully explain the associated antidiabetic effect because BJ-treated mice still showed lower blood glucose level when compared with pair-fed controls. The adipokines pathway also seems to be involved because BJ significantly increased adiponectin levels in obese mice. Conclusions: This study shows that BJ decreases hyperglycemia in diabetic mice, at least in part by reversing adiponectin levels. BJ also protects young pre-diabetic mice from developing obesity and diabetes. Thus, BJ may represent a novel complementary therapy and a source of novel therapeutic agents against diabetes mellitus.

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Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait.

Cited by 237 publications

References 45 publications

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

A single HPLC‐PAD‐APCI/MS method for the quantitative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium

Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy mice

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