Anti-diabetic properties of three common Bidens pilosa variants in Taiwan

Chien, Shih‐Chang; Young, Paul; Hsu, Yi-Jou; Chen, Chun-Houh; Tien, Yong Ming; Shiu, Shang-Ying; Li, Tzu-Hsuan; Yang, Chih‐Wen; Marimuthu, Ponnusamy; Tsai, Leo Feng-Liang; Yang, Wen‐Chin

doi:10.1016/j.phytochem.2009.07.011

Cited by 79 publications

(83 citation statements)

References 31 publications

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“…Informer C also reported using Bidens pilosa to treat diabetes. Recent studies showed the anti-hyperglycemic properties of Bidens pilosa, the extracts of which decreased glucose and increased insulin levels in the serum of mice, corroborating the above-mentioned indication (Hsu et al, 2008;Chien et al, 2009). …”

Section: Resultssupporting

confidence: 63%

“…In addition, polyacetylenes from Bidens pilosa var. radiata seem also to present anti-diabetic and anti-hyperglicemic effects (Hsu et al, 2008;Chien et al, 2009). Furthermore, antibacterial, antifungal, antioxidant (Chiang et al, 2004Deba et al, 2007), antitumor (Kviecinski et al, 2008), antiulcer (Alvarez et al, 1999), vasorelaxant (Théophile et al, 2006 and immunomodulatory (Chiang et al, 2006;Chang et al, 2007) effects have been associated with Bidens pilosa compounds.…”

Section: Discussionmentioning

confidence: 99%

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Bidens pilosa L. (Asteraceae): traditional use in a community of southern Brazil

Borges

Matos

Moreira

et al. 2013

Rev. bras. plantas med.

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RESUMO:Bidens pilosa Linn (Asteraceae): Uso tradicional em uma comunidade do Sul do Brasil. O emprego correto de plantas para fins terapêuticos pela população requer o uso daquelas selecionadas por sua eficácia e segurança, com base na tradição popular e/ ou cientificamente validadas como medicinais. Bidens pilosa L. é uma espécie que ocorre amplamente em regiões tropicais sendo conhecida no Brasil pelo nome popular "picão-preto". Quatro agentes da pastoral da Saúde foram identificadas na região de Criciúma/ SC por possuírem maiores informações de cunho popular sobre Bidens pilosa. A pesquisa ocorreu por meio de entrevista, onde foram compiladas informações sobre o conhecimento do "picão-preto", manuseio, farmacógeno, proporção farmacógeno/ solvente, técnica de preparo, formas de uso/posologia, indicações e restrições de uso. A forma farmacêutica utilizada variou significativamente, assim como a posologia. A análise de informações coletadas mostra a ação antiinflamatória como principal indicação terapêutica. Palavras-chave : planta medicinal, Bidens pilosa L., conhecimento popular, atividade antiinflamatória. ABSTRACT:The correct use of plants for therapeutic purposes requires selection of those showing efficacy and safety based on the popular tradition and/or scientific validation. Bidens pilosa L. is a species that widely occurs in tropical regions and is known in Brazil as "picão-preto". Four agents from the Health Pastoral Service were identified in the region of Criciuma, Santa Catarina State, for their popular knowledge of Bidens pilosa. The study was conducted by means of interview which provided data concerning the knowledge of "picão preto", handling, used plant part, plant/solvent proportion, preparation methods, administration route/dosage, indication and restrictions. The pharmaceutical form, as well as the posology, was significantly variable. Analysis of the collected data showed anti-inflammatory action as the main therapeutic indication.

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Section: Resultssupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Bidens pilosa L. (Asteraceae): traditional use in a community of southern Brazil

Borges

Matos

Moreira

et al. 2013

Rev. bras. plantas med.

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“…Further, a mixture of both compounds significantly reduced blood glucose levels and food intake in db/db mice [75]. Another study confirmed that water extracts of B. pilosa at one and multiple doses significantly lowered fasting and postmeal hyperglycemia in db/db mice [76]. The anti-hyperglycemic effect of B. pilosa was inversely correlated with an increase in serum insulin levels, suggesting that BPWE acts to lower blood glucose via increased insulin production.…”

Section: Selected Medicinal Herbs and Compounds For T2dmentioning

confidence: 95%

“…pilosa (BPP), and B. pilosa L. var. minor (BPM) all displayed antidiabetic activity in db/db mice [76]. Another polyyne isolated from B. pilosa , 2-ß- d -glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne (cytopiloyne) showed better glycemic control than the previously-mentioned polyynes [53].…”

Section: Selected Medicinal Herbs and Compounds For T2dmentioning

confidence: 99%

Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds

Chang

Lin

Bartolome

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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205

159

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Diabetes mellitus has been recognized since antiquity. It currently affects as many as 285 million people worldwide and results in heavy personal and national economic burdens. Considerable progress has been made in orthodox antidiabetic drugs. However, new remedies are still in great demand because of the limited efficacy and undesirable side effects of current orthodox drugs. Nature is an extraordinary source of antidiabetic medicines. To date, more than 1200 flowering plants have been claimed to have antidiabetic properties. Among them, one-third have been scientifically studied and documented in around 460 publications. In this review, we select and discuss blood glucose-lowering medicinal herbs that have the ability to modulate one or more of the pathways that regulate insulin resistance, β-cell function, GLP-1 homeostasis, and glucose (re)absorption. Emphasis is placed on phytochemistry, anti-diabetic bioactivities, and likely mechanism(s). Recent progress in the understanding of the biological actions, mechanisms, and therapeutic potential of compounds and extracts of plant origin in type 2 diabetes is summarized. This review provides a source of up-to-date information for further basic and clinical research into herbal therapy for type 2 diabetes. Emerging views on therapeutic strategies for type 2 diabetes are also discussed.

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“…pilosa and Bidens pilosa L. var. minor [12]. They are usually employed in traditional medicines as a remedy to treat various diseases, such as hepatitis, stomach disorders, diabetes, hypertension, malaria, inflammation and digestive disorders [13].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-proliferative Activities of Flavonoids from <i>Bidens pilosa</i> L var <i>radiata</i> Sch Bip

Yi¹,

Wu²,

Wu³

et al. 2016

Trop. J. Pharm Res

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Anti-diabetic properties of three common Bidens pilosa variants in Taiwan

Cited by 79 publications

References 31 publications

Bidens pilosa L. (Asteraceae): traditional use in a community of southern Brazil

Bidens pilosa L. (Asteraceae): traditional use in a community of southern Brazil

Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds

Antioxidant and Anti-proliferative Activities of Flavonoids from <i>Bidens pilosa</i> L var <i>radiata</i> Sch Bip

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