Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats

Abstract

Background:Cuminum cyminum Linn. (Umbelliferae), commonly known as Jeera. It is native from mediterranean region, but today widely cultivated in Asian countries. It has been reported to possess various medicinal properties and an important food ingredient. The seed of the plant are claimed for treatment of diarrhoea by various traditional practitioners.Objectives:Hence, the present investigation was undertaken to evaluate aq. extract of C. cyminum seeds (ACCS) against diarrhoea on albino rats.Materials and Methods:The animals were divided into five groups and the control group was applied with 2% acacia suspension, the standard group with loperamide (3 mg/kg) or atropine sulphate (5mg/kg) and three test groups administered orally with 100, 250 and 500 mg/kg of ACCS. The antidiarrhoeal effect was investigated by castor oil induce diarrhoea model, prostaglandin E2 (PGE2) induced enteropooling model, intestinal transit by charcoal meal test.Results:The ACCS showed significant (P < 0.001) inhibition in frequency of diarrhoea, defecation time delaying, secretion of intestinal fluid as well as intestinal propulsion as compared to control and the graded doses of tested extract followed dose dependent protection against diarrhoea.Conclusions:The study reveals that the ACCS is a potent antidiarrhoeal drug which supports the traditional claim.

Comparative analysis on bioactive compounds and antioxidant activity of Algerian fenugreek (Trigonella foenum-graecumL.) and Syrian cumin (Cuminum cyminumL.) seeds

“…A recent study of Megha et al [37] concerning the qualitative analysis of cumin registered a moderate presence of alkaloids, flavonoids, steroids, carbohydrate, phenol and terpenoids, whereas tannins, saponins, protein, glycosides and cardiac glycosides were reported to be absent in this plant extract. Furthermore, Himanshu et al [77] reported the richness of cumin extract with alkaloids, glycosides, flavonoids, tannins, terpenoids and phenolic compounds which are in the contrary to our results.…”

Immune-Modulatory Effects upon Oral Application of Cumin-Essential-Oil to Mice Suffering from Acute Campylobacteriosis

“…Despite the high gastrointestinal pathogen burdens, cumin-EO treated mice suffered less distinctly from clinical signs of acute campylobacteriosis as indicated by less pronounced diarrheal and wasting symptoms. These results are in line with a previous in vivo study showing that the single-dose administration of cumin extracts (500 mg/kg body weight) alleviated castor-oil-induced diarrhea in rats as indicated by lower fecal weight, less frequent defecation, and extended defecation times [32].…”

Antidiarrhoeal investigation of Apium leptophyllum (Pers.) by modulation of Na+K+ATPase, nitrous oxide and intestinal transit in rats

“…The antidiarrhoeal effect of FFALF may be also due to an inhibition of muscle contraction, as observed by charcoal meal and consequently, in a reduction of intestinal propulsion. The inhibition of intestinal muscle contraction is due to presence of flavonoidal constituents [6] . The cumulative results of this study revealed that the FFALF possesses antidiarrhoeal activity by reducing the frequency of diarrhoeal stool, weight and volume of intestinal content and intestinal transit as compared to standards ( Fig.…”

“…In addition, these management options which often fail during high stool output state are also associated with undesirable side effects such as bronchospasm, headache, convulsion, abdominal cramp, vomiting, constipation, hallucination etc. In order to overcome these menace of anti-diarrhoeal drugs in world market, WHO has introduced a programme, which encourages towards traditional herbal medicines [6] .…”