Anti-diuretic hormone and genetic study in primary nocturnal enuresis

Fatouh, Amany; Motawie, Ayat A.; Al-Aziz, Amany M. Abd; Hamed, Hanan; Awad, Mona; El-Ghany, Amany Abd; El-Bassyouni, Hala T.; Shehab, Marwa; Eid, Maha M.

doi:10.1016/j.jpurol.2012.11.009

Cited by 16 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low blood oxygen in the developing brain might also change the normal circadian rhythm of the antidiuretic hormone (ADH). It has been suggested in a number of studies that in a normal situation plasma ADH levels might increase at night to reduce urine production, and then decrease during the day 17,18 . This ADH rhythm might be absent in patients suffering from NE and previous studies have reported that a reversed ADH rhythm could in part contribute to NE in children and adolescents 19 .…”

Section: Discussionmentioning

confidence: 99%

Nocturnal enuresis in obese children: a nation-wide epidemiological study from China

Zhang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Childhood obesity increases the risk of obstructive sleep apnea syndrome, type 2 diabetes mellitus, cardiovascular abnormalities, and psychological and behavioral disorders. But it is unclear whether obesity is associated with childhood nocturnal enuresis (NE). This study aimed to assess the relationship between childhood obesity and NE in a nationally representative large sample in China. Subjects were enrolled from Urumqi, Chengdu, Xi’an, Hohhot, Wuhan, Canton, Shanghai, and Harbin cities in China in November and December 2005. The survey included 20,987 children aged 5–12 years and they and their caregivers completed questionnaires. Height and weight were measured by school teachers trained in healthcare. According to the WHO child growth standards, obesity was defined as a body mass index >95 th percentile of peers with the same age and gender. NE was defined as bed wetting for more than twice a week for 3 consecutive months. Demographic variables were compared among different groups. The prevalence of obesity, asthma, attention-deficit/hyperactivity disorder (ADHD), depressive moods, and snoring were different between the NE and without-NE groups (P < 0.05). The raw odds ratio (OR) for NE and obesity was 1.36 (95%CI = 1.07–1.74; P = 0.013) and the adjusted OR was 1.42 (95%CI = 1.11–1.82; P = 0.005) in the multivariable analysis. When adjusting for co-occurring conditions, the results showed that asthma did not affect the risk of NE (OR = 1.42, 95%CI = 1.11–1.82; P = 0.005), but ADHD (OR = 1.41; 95%CI = 1.10–1.81; P = 0.006) and depressive moods (OR = 1.34; 95%CI = 1.07–1.76; P = 0.012) slightly weakens the association between NE in children and obesity, while snoring weakens the association between obesity and NE and the risk became non-significant (OR = 1.21; 95%CI = 0.94–1.56; P = 0.138). In conclusion, obese children were at a higher risk of incurring NE compared to non-obese children. This association was weaker in children who either snored, had ADHD, or had depressive mood.

show abstract

Section: Discussionmentioning

confidence: 99%

Nocturnal enuresis in obese children: a nation-wide epidemiological study from China

Zhang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In this study, 63.3% wetted after midnight, which may reflect the circadian rhythm of anti-diuretic hormone (ADH) and bladder filling in the second half of the night [21]. A study from Slovenia reported that 50.0% of children wetted more frequently after midnight, while only 15% wetted more frequently before midnight [13].…”

Section: Discussionmentioning

confidence: 58%

“…Thus, the NE genotype may differ markedly among ethnicities. Studies support a strong relationship between NE and several genes on chromosomes 8, 12, 13 and 22, although further studies are needed to identify the specific genes and the underlying etiologies [21,[24][25][26].…”

Section: Discussionmentioning

confidence: 99%

High Concurrence of Nocturnal Enuresis and Associated Factors among South Chinese Children

Xu¹,

Liu²,

Jiang³

et al. 2017

Ann of Behav Sci

View full text Add to dashboard Cite

show abstract

“…Nocturnal enuresis, or nightly bedwetting in children more than seven years of age affects about 10% of seven-year-old to chromosome 22 [80]. The association between 5HTR2A gene polymorphisms and polysymptomatic NE was reported by Wei, et al suggesting that genetic variations at 5HTR2A may in luence NE treatment response [81].…”

Section: Primary Nocturnal Enuresis (Pne)mentioning

confidence: 97%

Do genes matter in sleep?-A comprehensive update

Dutta¹

2020

J Neurosci Neurol Disord

View full text Add to dashboard Cite

NREM sleep is found consistently to be under strong genetic control in humans and animal models as compared to REM sleep [26][27][28]. REM sleep amount was found to be signi icantly AbstractSleep is considered as a complex process in human beings and is least understood mechanism. Role of sleep in synaptic plasticity remains a debatable topic till date. Sleep is infl uenced by genetic background of the individual. EEG done in human sleep showed strong infl uence of genetic factors. A handful of familial analyses involving specifi c gene loci and twin studies has been done in this regard. In this review article focused discussion on genetic contribution to sleep phenotypes, twin and familial linkage studies and effect of genetic variation on sleep will be covered.Do genes matter in sleep?-A comprehensive update https://www.heighpubs.org/jnnd 015 https://doi.

show abstract

Anti-diuretic hormone and genetic study in primary nocturnal enuresis

Cited by 16 publications

References 26 publications

Nocturnal enuresis in obese children: a nation-wide epidemiological study from China

Nocturnal enuresis in obese children: a nation-wide epidemiological study from China

High Concurrence of Nocturnal Enuresis and Associated Factors among South Chinese Children

Do genes matter in sleep?-A comprehensive update

Contact Info

Product

Resources

About