Anti‐DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients

Hahn, Bevra H.; Anderson, Marissa; Le, Elizabeth N.; Cava, Antonio La

doi:10.1002/art.23609

Cited by 57 publications

(38 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7), thereby indicating that the hCDR1 induced CD4 ϩ CD25 ϩ FoxP3 ϩ cells played a key role in the regulation of SLE associated genes. Our findings are supported by a recent report of an anti-DNA Ig-derived peptide that upregulated in vitro the number and function of CD4 ϩ CD25 ϩ cells of SLE patients [37].…”

Section: Discussionsupporting

confidence: 91%

The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients

Sthoeger¹,

Sharabi²,

Dayan³

et al. 2009

Human Immunology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients

Sthoeger¹,

Sharabi²,

Dayan³

et al. 2009

Human Immunology

View full text Add to dashboard Cite

“…5), implying that leptin could use multiple modalities to inhibit Tregs. This might be relevant for SLE, where an inhibition of Tregs conversion could contribute to the reduced Tregs function that characterizes the disease (22). In other words, by inhibiting Tregs conversion, leptin could help to reduce availability of these key suppressor cells in the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Total IgG, anti-RNP, ANA, and anti-ssDNA Ab were measured using Alpha Diagnostic ELISA kits, according to the manufacturer's instructions. Anti-dsDNA Ab titers were also quantified by ELISA, as previously described (22). Anti-chromatin Ab were detected in sera that had been diluted 1:500, using chicken chromatin (kind gift from Minoru Satoh, University of Florida, Gainesville, FL) as plate-coating antigen and using HRP-conjugated anti-mouse IgG (Promega) for detection.…”

Section: Methodsmentioning

confidence: 99%

Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation

Lourenço

Liu

Matarese

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Leptin is an adipocytokine that plays a key role in the modulation of immune responses and the development and maintenance of inflammation. Circulating levels of leptin are elevated in systemic lupus erythematosus (SLE) patients, but it is not clear whether this association can reflect a direct influence of leptin on the propathogenic events that lead to SLE. To investigate this possibility, we compared the extent of susceptibility to SLE and lupus manifestations between leptin-deficient (ob/ob) and H2-matched leptinsufficient (wild-type, WT) mice that had been treated with the lupus-inducing agent pristane. Leptin deficiency protected ob/ob mice from the development of autoantibodies and renal disease and increased the frequency of immunoregulatory T cells (Tregs) compared with leptin-sufficient WT mice. The role of leptin in the development of SLE was confirmed in the New Zealand Black (NZB) × New Zealand White (NZW)F 1 (NZB/W) mouse model of spontaneous SLE, where elevated leptin levels correlated with disease manifestations and the administration of leptin accelerated development of autoantibodies and renal disease. Conversely, leptin antagonism delayed disease progression and increased survival of severely nephritic NZB/W mice. At the cellular level, leptin promoted effector T-cell responses and facilitated the presentation of self-antigens to T cells, whereas it inhibited the activity of regulatory CD4 T cells. The understanding of the role of leptin in modulating autoimmune responses in SLE can open possibilities of leptin-targeted therapeutic intervention in the disease.systemic lupus erythematosus | leptin | autoimmunity | immune regulation | animal models

show abstract

“…Quantitative and/or qualitative deficiencies of Tregs have been associated with the development of autoimmune diseases [5,6]. Previous studies have shown that a deficiency in Tregs is associated with the development of lupus-like characteristics, including glomerulonephritis and the development of DNA-specific antibodies [7][8][9]. Human Tregs are CD4…”

Section: Introductionmentioning

confidence: 99%

Imbalance of different types of CD4+forkhead box protein 3 (FoxP3)+ T cells in patients with new-onset systemic lupus erythematosus

Zhao

Jiang

et al. 2013

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

Anti‐DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients

Cited by 57 publications

References 46 publications

The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients

The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients

Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation

Imbalance of different types of CD4+forkhead box protein 3 (FoxP3)+ T cells in patients with new-onset systemic lupus erythematosus

Contact Info

Product

Resources

About