Anti-Donor Hla Antibodies Associated With Allograft Arteriopathy Detected Using Intravascular Ultrasound

Donor‐specific HLA antibodies in paediatric cardiac transplant recipients are associated with poor graft survival

“…This study also showed that the presence of preformed antibodies were more frequently associated with the prevalence of CAV, although the association of these antibodies with chronic rejection in this population could not be conclusively demonstrated. This finding, however, agrees with those from adult studies, which show that when HLA antibodies were present, there was an increase in chronic rejection in the form of coronary vasculopathy (13). This study did not, however, assess the presence of DSA.…”

Anti-Human Leukocyte Antigen Antibodies are Associated with Restenosis after Percutaneous Coronary Intervention for Cardiac Allograft Vasculopathy

“…We previously reported an association between antibody to MHC class II antigen and episodes of myocardial rejection (19). Others have demonstrated correlations between antibodies to MHC class I antigen and the development of CAV (6,10,11). Donor-heart endothelium constitutively expresses donor MHC I and can express donor MHC II after injury, but whether the anti-HLA antibodies have a causative role is unknown.…”

“…The etiology remains unknown, but vascular injury from allorejection has been suspected to play a role. Inflammatory cytokines, nonspecific inflammatory markers, and anti-human leukocyte antigen (HLA) antibodies have been associated with its development and with graft failure (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”