2012
DOI: 10.1016/j.abb.2012.03.005
|View full text |Cite
|
Sign up to set email alerts
|

Anti-EGFR biparatopic-SEED antibody has enhanced combination-activity in a single molecule

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
14
0

Year Published

2012
2012
2024
2024

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 19 publications
(14 citation statements)
references
References 19 publications
0
14
0
Order By: Relevance
“…2, box 9 ). 180 This biparatopic antibody demonstrated enhanced activity, similar to the combination of the two parental antibodies.…”
Section: Bispecific Iggs With Asymmetric Architecturementioning
confidence: 83%
“…2, box 9 ). 180 This biparatopic antibody demonstrated enhanced activity, similar to the combination of the two parental antibodies.…”
Section: Bispecific Iggs With Asymmetric Architecturementioning
confidence: 83%
“…The concept of enhancing the internalization and degradation of receptors by promoting the formation of antibody/receptor clusters on the cell surface has been explored fairly extensively (19,20,31,32,(37)(38)(39)(40)(41)(42)(43). The ability of antibodies to promote receptor degradation could result from an increased rate of receptor internalization, a decrease in receptor recycling or both.…”
Section: Discussionmentioning
confidence: 99%
“…It inhibits the autophosphorylation of EGFR, blocking downstream signaling transduction pathways, and inhibits signal transmission of cell mitosis, which is activated by growth factor and prevents tumor cell proliferation [ 15 ]. In addition, the combination of C225 and EGFR can also induce the engagement of receptors in dimerization, internalization and down-regulation [ 16 ]. C225 can inhibit the progression of the cell cycle from the G1 stage to S stage, induce apoptosis of tumor cells, inhibit tumor angiogenesis and inhibit the invasion and metastasis of tumors by a variety of activators [ 17 ].…”
Section: Discussionmentioning
confidence: 99%