Anti-emetic effect of ondansetron and palonosetron in thyroidectomy: a prospective, randomized, double-blind study

Abstract

Palonosetron is more effective than ondansetron for high-risk patients receiving fentanyl-based PCA after thyroidectomy, especially 2-24 h after surgery.

A Comparative Study of Ondansetron and Palonosetron as Antiemetics for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries

“…9 and Moon YE, Joo J, Kim JE, Lee Y (2012). 10 in which severity of nausea was significantly lower in the Palonosetron group than in the Ondansetron group during 2-24 hours. In Bajwa SS (2012).…”

“…9 and Moon YE, Joo J, Kim JE, Lee Y (2012). 10 In Bajwa SS (2011). 11 study 13.33% of Ondansetron group and 3.33% of Palonosetron group had vomiting which was significant (p<0.05) and comparable to our study.…”

Efficacy of palonosetron for preventing postoperative nausea and vomiting: a systematic review and meta-analysis

“…We then retrieved the full texts of the remaining 16 citations and excluded seven of these citations because five among them had no intended interventions and two had no outcomes of interest. Altogether, nine studies [25][26][27][28][29][30][31][32][33] fulfilled the criteria for systematic review and meta-analysis. The study selection processes are shown in Fig.…”

“…In 2008, the FDA approved a single intravenous dose of palonosetron for PONV prophylaxis for up to 24 hours based on the results of two earlier dose-ranging studies. 48,49 Subsequently, most studies [25][26][27][28][29][30][31][32][33] chose palonosetron 0.075 mg as the dose to administer in their trials, which makes it difficult to re-evaluate the optimal dose of palonosetron.…”

Effects of palonosetron and dexamethasone on postoperative nausea and vomiting in adult patients undergoing laparoscopic abdominal surgery: a randomized, double-blind, clinical trial at a tertiary care hospital

“…It was reported that palonosetron was more effective than ondansetron in preventing chemotherapy-induced nausea and vomiting (CINV) and PONV. 13,14 Corticosteroids like dexamethasone are thought to exert antiemetic properties by inhibiting prostaglandin synthesis or the release of endogenous opioids with negligible side effects. 15 Dexamethasone is a low price corticosteroid which has anti-inflammatory effects, and some studies have also evaluated its effect on nausea and vomiting prophylaxis after chemotherapy.…”