Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy

Ahmedzai, Sam H; Carlyle, Daniel; Calder, I T; Moran, F.

doi:10.1038/bjc.1983.247

Cited by 70 publications

(46 citation statements)

References 11 publications

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“…35 36 58-60 In nine trials, all patients were reported not to have used cannabis previously. 33 34 39 41-43 46 49 51 In the other 16 trials, it was unclear whether patients had used cannabis previously.…”

Section: Resultsmentioning

confidence: 99%

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Tramèr

Carroll²,

Campbell³

et al. 2001

BMJ

520

264

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Section: Resultsmentioning

confidence: 99%

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Tramèr

Carroll²,

Campbell³

et al. 2001

BMJ

520

264

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show abstract

“…It binds to cannabinoid receptors like D 9 -THC but was found to be without psychoactive properties [5,6]. It is the only legally available cannabinoid preparation in the United Kingdom and is licensed solely for use in reduction of nausea and vomiting induced by chemotherapy [7,8].…”

mentioning

confidence: 99%

Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain

et al. 2006

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About 30% of patients with chronic upper motor neuron syndrome (UMNS) suffer from disabling spasticity-related pain not sufficiently correctable by conventional treatment. Delta9-tetrahydrocannabinol (Delta(9)-THC) was reported to add benefit in the treatment of pain in patients with multiple sclerosis (MS). The question arose whether synthetic cannabinoids with lower potential for psychotropic side effects could be effective as well. To evaluate the safety and efficacy of low dose treatment with the synthetic cannabinoid Nabilone (1 mg per day) on spasticity-related pain a placebo-controlled double-blind crossover trial was performed.11 out of 13 included patients completed the study. The 11-Point-Box-Test showed a significant decrease of pain under Nabilone (p < 0.05), while spasticity, motor function and activities of daily living did not change. 5 patients reported side effects: one moderate transient weakness of the lower limbs (Nabilone phase, drop out), three mild drowsiness (two Nabilone, one placebo) and one mild dysphagia (placebo). One patient was excluded from the study due to an acute relapse of multiple sclerosis (Nabilone phase, drop out). Nabilone 1 mg per day proved to be a safe and easily applicable option in the care of patients with chronic UMNS and spasticity-related pain otherwise not controllable.

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“…Die orale Applikation von Nabilone wurde in 16 Studien untersucht [1,5,6,7,10,12,14,17,20,25,26,28,38], Dronabinol in 13 Studien [3,4,11,13,18,19,23,24,27,31,32,41] und die intramuskuläre Gabe von Levonantradol in einer Studie [16]. In diesen Studien wurden Cannabinoide nach 1-6 Chemotherapiezyklen eingesetzt und die antiemetische Effektivität über 24 h untersucht.…”

Section: Nabilone Dronabinol Und Levonantradolunclassified

Cannabinoide in der Behandlung von �belkeit und Erbrechen

Radbruch

Nauck

2004

Schmerz

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Cannabinoids are used to treat nausea and vomiting. The effect appears to be mediated by cannabinoid receptors in the nucleus tractus solitarius. Results are available from studies on the use of cannabinoids to manage nausea and vomiting after chemotherapy. None of these studies, however, compared cannabinoids with the newer serotonin antagonists. The antiemetic efficacy of cannabinoids for other indications has not yet been studied sufficiently. Most of the studies report significantly more or stronger side effects with cannabinoid medication in comparison to similar medication. In some of the studies on treatment after chemotherapy or radiotherapy, the patients terminated the cannabinoid therapy more frequently due to side effects. Although clinical studies have provided clear evidence for the antiemetic efficacy of cannabinoids, the frequency and severity of side effects argue against their use as the method of first choice. For patients who cannot be adequately treated with conventional antiemetic agents, cannabinoids can represent a valuable adjunct to the antiemetic regimen.

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Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy

Abstract: Nabilone is an effective oral anti-emetic drug for moderately toxic chemotherapy, but the range and unpredictability of its side-effects warrant caution in its use.

Cited by 70 publications

References 11 publications

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain

Cannabinoide in der Behandlung von �belkeit und Erbrechen

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