Anti-Erythrocyte Autoimmunisation During Chronic Falciparum Malaria

Lefrançois, G.; Bras, J. Le; Simonneau, M.; Bouvet, E.; Vroklans, M.; Vachon, F

doi:10.1016/s0140-6736(82)91002-9

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…In P. vivax infection, a decrease in the hemoglobin level is almost certainly due to drug-induced hemolysis owing to the low parasite count. Uncommonly, hemolysis may continue after malaria is cured, possibly due to persisting antibodies against eryhtrocytes, 82,83 although their role must be considered controversial. 84…”

Section: Drug-induced G6pd Deficiency-related Hemolysismentioning

confidence: 99%

Glucose-6-Phosphate Dehydrogenase Deficiency and Antimalarial Drug Development

Beutler

Duparc²

2007

Am J Trop Med Hyg

185

174

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is relatively common in populations exposed to malaria. This deficiency appears to provide some protection from this infection, but it can also cause hemolysis after administration of some antimalarial drugs, especially primaquine. The risk of drug-induced G6PD deficiency-related hemolysis depends on a number of factors including the G6PD variant, the drug and drug dosage schedule, patient status, and disease factors. Although a great deal is known about the molecular biology of G6PD, determining the potential for drug-induced hemolysis in the clinical setting is still challenging. This report discusses the potential strategies for assessing drug-induced G6PD deficiency-related hemolytic risk preclinically and in early clinical trials. Additionally, the issues important for conducting larger clinical trials in populations in which G6PD deficiency is prevalent are examined, with a particular focus on antimalarial drug development.

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Section: Drug-induced G6pd Deficiency-related Hemolysismentioning

confidence: 99%

Glucose-6-Phosphate Dehydrogenase Deficiency and Antimalarial Drug Development

Beutler

Duparc²

2007

Am J Trop Med Hyg

185

174

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“…It was also observed that levels of anti-PS antibodies are correlated with malarial anemia in patients 14,15 . Although autoantibodies have been reported in experimental models of malaria and patient populations 16–18 , few studies have investigated the relationship between autoantibodies and SM complications. Acute kidney injury (AKI) is a common complication in pediatric SM associated with significant morbidity and mortality 4,19,20 , but the pathogenesis is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Rivera-Correa

Conroy

Opoka

et al. 2019

Sci Rep

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Autoantibodies targeting host antigens contribute to autoimmune disorders, frequently occur during and after infections and have been proposed to contribute to malaria-induced anemia. We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruited in a study of severe malaria (SM). High antibody levels were defined as antibody levels greater than the mean plus 3 standard deviations of community children (CC). We observed increases in median levels of anti-PS and anti-DNA antibodies in children with SM compared to CC (p < 0.0001 for both). Children with severe malarial anemia were more likely to have high anti-PS antibodies than children with cerebral malaria (16.4% vs. 7.4%), p = 0.02. Increases in anti-PS and anti-DNA antibodies were associated with decreased hemoglobin (p < 0.05). A one-unit increase in anti-DNA antibodies was associated with a 2.99 (95% CI, 1.68, 5.31) increase odds of acute kidney injury (AKI) (p < 0.0001). Elevated anti-PS and anti-DNA antibodies were associated with post-discharge mortality (p = 0.031 and p = 0.042, respectively). Children with high anti-PS antibodies were more likely to have multiple hospital readmissions compared to children with normal anti-PS antibody levels (p < 0.05). SM is associated with increased autoantibodies against PS and DNA. Autoantibodies were associated with anemia, AKI, post-discharge mortality, and hospital readmission.

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A Role for Autoimmunity in the Immune Response Against Malaria

Rivera-Correa

Rodrı́guez

2017

Malaria

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Anti-Erythrocyte Autoimmunisation During Chronic Falciparum Malaria

Cited by 8 publications

References 9 publications

Glucose-6-Phosphate Dehydrogenase Deficiency and Antimalarial Drug Development

Glucose-6-Phosphate Dehydrogenase Deficiency and Antimalarial Drug Development

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

A Role for Autoimmunity in the Immune Response Against Malaria

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